Human Genome Sequencing Center Clinical Lab

Human Genome Sequencing Center Clinical LaboratoryThe HGSC Clinical Laboratory (HGSC-CL) is the CAP/CLIA certified molecular diagnostic laboratory operating within the Human Genome Sequencing Center at Baylor College of Medicine.

With a commitment to improving health care through genomic testing, HGSC-CL offers clinical testing services in support of large-scale clinical sequencing efforts.

Texas Medical Center Genomic Center for Infectious Diseases

coronavirusThe Texas Medical Center Genomic Center for Infectious Diseases (TMC GCID) is the collaborative effort of a multidisciplinary, integrated team of basic and physician scientists at three institutions — Baylor College of Medicine, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health, and The University of Texas MD Anderson Cancer Center.

The TMC GCID harnesses decades of experience in genomic sequencing, renowned clinical expertise and the use of novel ex vivo models of human intestinal and pulmonary function to create a platform for large scale genomics-based interrogation of host-mucosal pathogen interactions in the context of human tissues.

BCM-HGSC Long Read Sequencing Laboratory

DNA artworkThe BCM-HGSC has been a leading institution in the development of cost effective, large-scale sequencing methods across a multitude of sequencing platforms, testing more than 250,000 samples. Our current instrumentation includes the Pacific Biosciences Sequel II and the Oxford Nanopore Technologies PromethION, and we are closely engaged with each of these platforms to test improvements to sequencing chemistry and software including early access to new protocols. Given the large capacity of these platforms, long read sequencing opportunities are available to those interested.

Everything is bigger in Texas: Pan-Structural Variation hackathon in the Cloud!

Pan Structural Variation Hackathon in the Cloud, Aug. 28-31, 2024

The “Structural Variant Crying Club” is pleased to announce the 6th round of Structural Variants in the Cloud Hackathon, August 28-31, 2024. This hybrid event will include opportunities for participation in person or online over Zoom. Researchers, including students and postdocs, who have experience working with structural variants, complex disease, precision medicine, and similar genomic analysis were invited to apply.

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Long Read Sequencing Seminar Series

Since January 2021, the Human Genome Sequencing Center has hosted an ongoing series of webinars focused on long read sequencing to create a community of researchers and clinicians using this technology in their studies. This seminar is designed for researchers, clinicians, and industry professionals who are interested in leveraging nanopore sequencing for advanced genomic studies.

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Primate genomes studies published in Science

A new investigation led by researchers at Baylor College of Medicine’s Human Genome Sequencing Center, the Institute of Evolutionary Biology and Pompeu Fabra University in Barcelona, Spain, and Illumina, Inc. analyzed the genomes of 233 nonhuman primate species and revealed key features of primate evolution, human disease and biodiversity conservation. The findings are published in a series of studies in a special issue of the journal Science.

› Read the special issue of Science
› Read announcement from Baylor College of Medicine

Human Genome Sequencing Center awarded a grant from National Institute of Standards and Technology (NIST)

The Baylor College of Medicine Human Genome Sequencing Center (BCM-HGSC) was recently awarded a grant by the National Institute of Standards and Technology (NIST). The Genome in a Bottle (GIAB) consortium led by NIST routinely develops reference datasets for technology and method standardizations within and across entities. Principal Investigators Drs. Harsha Doddapaneni and Fritz Sedlazeck, who are each Associate Professors in the BCM-HGSC, said that the significance of this effort is that new datasets, including RNA-Seq references for existing GIAB samples and new cancer (tumor-normal) information, will improve standardization and calibration in ongoing genome studies.

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Towards population-scale long-read sequencing

Advances in long-read sequencing technologies and bioinformatics have enabled the first population-scale studies with long-read sequencing in recent years. In a new review published in Nature Review Genetics, Dr. Fritz Sedlazeck and colleagues discuss these recent developments and highlight project strategies for experimental design with Pacific Biosciences and Oxford Nanopore Technology systems.

Uniquely comprehensive Pan-Cancer Atlas provides essential resource

A collection of 27 papers from The Cancer Genome Atlas (TCGA) consortium has been published reporting on the integrated project to analyze all 33 cancer types and to classify mutations and specific pathways. Many of the papers feature significant contributions from Baylor College of Medicine and its Human Genome Sequencing Center researchers. The findings from the 11,000 patient cohort data appear in Cell publications.


BCM-HGSC in the News

About Us

The BCM-HGSC, founded in 1996, is a world leader in genomics.

The fundamental interests of the BCM-HGSC are in advancing biology and genetics by improved genome technologies.

One of three large-scale sequencing centers funded by the National Institutes of Health, the BCM-HGSC's location at the heart of the Texas Medical Center provides a unique opportunity to apply the cutting edge of genome technologies in science and medicine.

Learn more about the BCM-HGSC

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Dr. Paul Klotman discusses Pangenome with Drs. Richard Gibbs and Amy McGuire

Human Genome Project marks 20th anniversary

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