Human Genome Sequencing Center Clinical Lab

Human Genome Sequencing Center Clinical LaboratoryThe HGSC Clinical Laboratory (HGSC-CL) is the CAP/CLIA certified molecular diagnostic laboratory operating within the Human Genome Sequencing Center at Baylor College of Medicine.

With a commitment to improving health care through genomic testing, HGSC-CL offers clinical testing services in support of large-scale clinical sequencing efforts.

Texas Medical Center Genomic Center for Infectious Diseases

coronavirusThe Texas Medical Center Genomic Center for Infectious Diseases (TMC GCID) is the collaborative effort of a multidisciplinary, integrated team of basic and physician scientists at three institutions — Baylor College of Medicine, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health, and The University of Texas MD Anderson Cancer Center.

The TMC GCID harnesses decades of experience in genomic sequencing, renowned clinical expertise and the use of novel ex vivo models of human intestinal and pulmonary function to create a platform for large scale genomics-based interrogation of host-mucosal pathogen interactions in the context of human tissues.

BCM-HGSC Long Read Sequencing Laboratory

DNA artworkThe BCM-HGSC has been a leading institution in the development of cost effective, large-scale sequencing methods across a multitude of sequencing platforms, testing more than 250,000 samples. Our current instrumentation includes the Pacific Biosciences Sequel II and the Oxford Nanopore Technologies PromethION, and we are closely engaged with each of these platforms to test improvements to sequencing chemistry and software including early access to new protocols. Given the large capacity of these platforms, long read sequencing opportunities are available to those interested.

COVID-19 Research

Like much of the research community at this urgent time, the Baylor College of Medicine Human Genome Sequencing Center (BCM-HGSC) has turned its focus primarily toward COVID-19 testing and research. With the safety and health of the community and our personnel in mind, the BCM-HGSC is operating with staff working remotely as much as possible while a rotating lab team continues critical research on site.

› Learn more about COVID-19 research at Baylor

Human Genome Sequencing Center awarded a grant from National Institute of Standards and Technology (NIST)

The Baylor College of Medicine Human Genome Sequencing Center (BCM-HGSC) was recently awarded a grant by the National Institute of Standards and Technology (NIST). The Genome in a Bottle (GIAB) consortium led by NIST routinely develops reference datasets for technology and method standardizations within and across entities. Principal Investigators Drs. Harsha Doddapaneni and Fritz Sedlazeck, who are each Associate Professors in the BCM-HGSC, said that the significance of this effort is that new datasets, including RNA-Seq references for existing GIAB samples and new cancer (tumor-normal) information, will improve standardization and calibration in ongoing genome studies.

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Towards population-scale long-read sequencing

Advances in long-read sequencing technologies and bioinformatics have enabled the first population-scale studies with long-read sequencing in recent years. In a new review published in Nature Review Genetics, Dr. Fritz Sedlazeck and colleagues discuss these recent developments and highlight project strategies for experimental design with Pacific Biosciences and Oxford Nanopore Technology systems.

Harmonizing Clinical Sequencing and Interpretation for the eMERGE III Network

A new paper available in preprint on bioRxiv describes the methods developed to harmonize genetic testing protocols linking multiple sites and investigators for the eMERGE III Network. The results mark a critical achievement toward global standardization of genetic testing by establishing protocols for different sites to harmonize the technical and interpretive aspects of sequencing tests. The integration of structured genomic results into multiple electronic health record systems by the eMERGE Network also sets the stage for clinical decision support to enable genomic medicine. 

Uniquely comprehensive Pan-Cancer Atlas provides essential resource

A collection of 27 papers from The Cancer Genome Atlas (TCGA) consortium has been published reporting on the integrated project to analyze all 33 cancer types and to classify mutations and specific pathways. Many of the papers feature significant contributions from Baylor College of Medicine and its Human Genome Sequencing Center researchers. The findings from the 11,000 patient cohort data appear in Cell publications.

Hybrid computational strategy for scalable whole genome data analysis

In a study published in BMC Bioinformatics, researchers from Baylor College of Medicine’s Human Genome Sequencing Center, along with Oak Ridge National Laboratory, DNAnexus and the Human Genetics Center at the University of Texas Health Science Center, have developed a novel hybrid computational strategy to address the growing need for scalable, cost effective and real time variant calling of whole genome sequencing data.

This new strategy has proven successful in analyzing an unprecedented set of 5,000 samples, which constitute a critical part for the international consortia efforts known as The Cohorts for Heart and Aging Research in Genomic Epidemiology, or CHARGE.

Assessing structural variation in a personal genome—towards a human reference diploid genome

DNA artIn a paper published in BMC Genomics, a team led by scientists from Baylor College of Medicine’s Human Genome Sequencing Center present Parliament, a structural variant (SV) calling pipeline that brings together multiple data types and SV detection methods to improve the characterization of these larger variants.

› Read the research article in BMC Genomics

 






About Us

The BCM-HGSC, founded in 1996, is a world leader in genomics.

The fundamental interests of the BCM-HGSC are in advancing biology and genetics by improved genome technologies.

One of three large-scale sequencing centers funded by the National Institutes of Health, the BCM-HGSC's location at the heart of the Texas Medical Center provides a unique opportunity to apply the cutting edge of genome technologies in science and medicine.

Learn more about the BCM-HGSC

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