Six Baylor College of Medicine faculty members were selected as recipients of the 2023 Michael E. DeBakey Excellence in Research Award. Dr. Fritz Sedlazeck and Dr. Jeffrey Rogers were among those recognized for their work during the Sept. 18 ceremony at Baylor.
Primate genome sequencing reveals insight into evolution, biodiversity and applications for human health
A new investigation published in a series of studies in a special issue of Science analyzed the genomes of 233 nonhuman primate species and revealed key features of primate evolution, human disease and biodiversity conservation.
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Baylor College of Medicine receives NIH funding to study somatic mosaicism
NIH Common Fund program called Somatic Mosaicism across Human Tissues (SMaHT) Network awarded BCM researchers grants totaling more than $17.8 million to develop tools cataloging extent of somatic mosaicism in different cell types, tissues and life stages.
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Celebrating 20 years since completion of Human Genome Project
The Baylor College of Medicine Human Genome Sequencing Center celebrates 20th anniversary of the Human Genome Project with a look back at the groundbreaking achievements of this historic endeavor and the future of genetic research.
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Mayo Clinic and Baylor study: drug-gene testing improves patient care
In a new study appearing in Genetics in Medicine, investigators from Mayo Clinic and Baylor College of Medicine found that targeted genomic information can play an important role in drug prescribing practices.
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New benchmark report provides accurate ID of variants in medically-relevant genes
Researchers from NIST, Baylor College of Medicine and DNAnexus, together with other members of the Genome in a Bottle consortium, announce the publication of a comprehensive benchmark dataset comprising 273 challenging medically relevant autosomal genes.
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Genetic cause of endometriosis IDed, potential drug target revealed
New research conducted by BCM, the University of Oxford, the University of Wisconsin-Madison and Bayer AG, offers new insight into how to treat this debilitating disease.
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Human Genome Sequencing Center Clinical Lab
The HGSC Clinical Laboratory (HGSC-CL) is the CAP/CLIA certified molecular diagnostic laboratory operating within the Human Genome Sequencing Center at Baylor College of Medicine.
With a commitment to improving health care through genomic testing, HGSC-CL offers clinical testing services in support of large-scale clinical sequencing efforts.
Texas Medical Center Genomic Center for Infectious Diseases
The Texas Medical Center Genomic Center for Infectious Diseases (TMC GCID) is the collaborative effort of a multidisciplinary, integrated team of basic and physician scientists at three institutions — Baylor College of Medicine, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health, and The University of Texas MD Anderson Cancer Center.
The TMC GCID harnesses decades of experience in genomic sequencing, renowned clinical expertise and the use of novel ex vivo models of human intestinal and pulmonary function to create a platform for large scale genomics-based interrogation of host-mucosal pathogen interactions in the context of human tissues.
BCM-HGSC Long Read Sequencing Laboratory
The BCM-HGSC has been a leading institution in the development of cost effective, large-scale sequencing methods across a multitude of sequencing platforms, testing more than 250,000 samples. Our current instrumentation includes the Pacific Biosciences Sequel II and the Oxford Nanopore Technologies PromethION, and we are closely engaged with each of these platforms to test improvements to sequencing chemistry and software including early access to new protocols. Given the large capacity of these platforms, long read sequencing opportunities are available to those interested.
Learning about Long Read Sequencing Utility and Applications
Our next Long Read Sequencing webinar is set for October 6. The Human Genome Sequencing Center at Baylor College of Medicine hosts quarterly virtual seminars encompassing various long read sequencing technologies applied to diverse research areas. The purpose of these seminars is to provide an environment to learn more about these technologies and how the scientific community is using these platforms in research and clinical environments.
Primate genomes studies published in Science
A new investigation led by researchers at Baylor College of Medicine’s Human Genome Sequencing Center, the Institute of Evolutionary Biology and Pompeu Fabra University in Barcelona, Spain, and Illumina, Inc. analyzed the genomes of 233 nonhuman primate species and revealed key features of primate evolution, human disease and biodiversity conservation. The findings are published in a series of studies in a special issue of the journal Science.
› Read the special issue of Science
› Read announcement from Baylor College of Medicine
Human Genome Sequencing Center awarded a grant from National Institute of Standards and Technology (NIST)
The Baylor College of Medicine Human Genome Sequencing Center (BCM-HGSC) was recently awarded a grant by the National Institute of Standards and Technology (NIST). The Genome in a Bottle (GIAB) consortium led by NIST routinely develops reference datasets for technology and method standardizations within and across entities. Principal Investigators Drs. Harsha Doddapaneni and Fritz Sedlazeck, who are each Associate Professors in the BCM-HGSC, said that the significance of this effort is that new datasets, including RNA-Seq references for existing GIAB samples and new cancer (tumor-normal) information, will improve standardization and calibration in ongoing genome studies.
Towards population-scale long-read sequencing
Advances in long-read sequencing technologies and bioinformatics have enabled the first population-scale studies with long-read sequencing in recent years. In a new review published in Nature Review Genetics, Dr. Fritz Sedlazeck and colleagues discuss these recent developments and highlight project strategies for experimental design with Pacific Biosciences and Oxford Nanopore Technology systems.
Uniquely comprehensive Pan-Cancer Atlas provides essential resource
A collection of 27 papers from The Cancer Genome Atlas (TCGA) consortium has been published reporting on the integrated project to analyze all 33 cancer types and to classify mutations and specific pathways. Many of the papers feature significant contributions from Baylor College of Medicine and its Human Genome Sequencing Center researchers. The findings from the 11,000 patient cohort data appear in Cell publications.
BCM-HGSC in the News
Baylor College of Medicine and Texas Children’s Hospital launch a new clinical genomic sequencing program to help patients with an undiagnosed condition
About 35% of severe developmental childhood genetic diseases have a known disease-causing gene mutation. Baylor College of Medicine and Texas Children’s Hospital researchers Dr. Hugo J. Bellen, Dr. Richard Gibbs and Dr. Katherine Y. King have launched a new genomic sequencing initiative to identify the genetic mutations and the underlying mechanisms responsible for the remaining two-thirds of these pediatric conditions.
Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations
Science takes a look at Somatic Mosaicism Across Human Tissues (SMaHT), an ambitious National Institutes of Health (NIH) project to map genomic diversity, and speaks with Dr. Harsha Doddapaneni who helps lead one of the SMaHT sequencing groups at the Baylor College of Medicine Human Genome Sequencing Center (BCM-HGSC).
Baylor College of Medicine Human Genome Sequencing Center adopts Olink® Explore HT proteomics platform
The Baylor College of Medicine Human Genome Sequencing Center is incorporating the Olink Explore HT proteomics platform into its portfolio of world-class multiomics. The addition of Olink proteomic technology enables a more thorough understanding of the intricate connections between genes, proteins, and diseases that will lead to improved diagnostics, targeted therapies and the advancement of precision and personalized medicine.
NIH Somatic Variant Detection Program to Develop Novel Assays, Computational Tools
GenomeWeb takes a look at the Somatic Mosaicism across Human Tissues (SMaHT) program, a National Institutes of Health Common Fund project to accelerate research on the impact of somatic mosiacism on human development, aging and disease. SMaHT researchers, including HGSC's Dr. Fritz Sedlazeck, weigh in on the challenges and benefits of this groundbreaking program.
About Us
The BCM-HGSC, founded in 1996, is a world leader in genomics.
The fundamental interests of the BCM-HGSC are in advancing biology and genetics by improved genome technologies.
One of three large-scale sequencing centers funded by the National Institutes of Health, the BCM-HGSC's location at the heart of the Texas Medical Center provides a unique opportunity to apply the cutting edge of genome technologies in science and medicine.
Dr. Paul Klotman discusses Pangenome with Drs. Richard Gibbs and Amy McGuire
Human Genome Project marks 20th anniversary
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