Nature Genetics

Purple plants

Nature Genetics 48, 587 (2016). doi:10.1038/ng.3585

The genetics of plant breeding cannot by itself end hunger and malnutrition nor ensure sustainable food production. However, driven by genomics, it provides tools with which to raise the research profile and standards of two related fields that together will do so: agronomy, as it relates to crop ecology and evolution, and nutritional natural products research.

The history of the Y chromosome in man

Nature Genetics 48, 588 (2016). doi:10.1038/ng.3580

Authors: Jennifer F Hughes & David C Page

Studies of the Y chromosome over the past few decades have opened a window into the history of our species, through the reconstruction and exploitation of a patrilineal (Y-genealogical) tree based on several hundred single-nucleotide variants (SNVs). A new study validates, refines and extends this tree by incorporating >65,000 Y-linked variants identified in 1,244 men representing worldwide diversity.

The carrot genome sequence brings colors out of the dark

Nature Genetics 48, 589 (2016). doi:10.1038/ng.3574

Authors: Jordi Garcia-Mas & Manuel Rodriguez-Concepcion

The genome sequence of carrot (Daucus carota L.) is the first completed for an Apiaceae species, furthering knowledge of the evolution of the important euasterid II clade. Analyzing the whole-genome sequence allowed for the identification of a gene that may regulate the accumulation of carotenoids in the root.

DNA-sequence-specific erasers of epigenetic memory

Nature Genetics 48, 591 (2016). doi:10.1038/ng.3579

Authors: Iva Mozgova & Claudia Köhler

How epigenetic regulators find their specific targets remains a challenging question. Two parallel studies show that REF6, a plant H3K27me3 demethylase, binds a specific DNA motif via its zinc-finger domains and recruits the SWI/SNF-type ATPase BRAHMA, demonstrating a sequence-specific recruitment mechanism for a chromatin-modifying complex.

Erratum: Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

Nature Genetics 48, 700 (2016). doi:10.1038/ng0616-700a

Author: Akihiro Fujimoto, Mayuko Furuta, Yasushi Totoki, Tatsuhiko Tsunoda, Mamoru Kato, Yuichi Shiraishi, Hiroko Tanaka, Hiroaki Taniguchi, Yoshiiku Kawakami, Masaki Ueno, Kunihito Gotoh, Shun-ichi Ariizumi, Christopher P Wardell, Shinya Hayami, Toru Nakamura, Hiroshi Aikata, Koji Arihiro, Keith A Boroevich, Tetsuo Abe, Kaoru Nakano, Kazuhiro Maejima, Aya Sasaki-Oku, Ayako Ohsawa, Tetsuo Shibuya, Hiromi Nakamura, Natsuko Hama, Fumie Hosoda, Yasuhito Arai, Shoko Ohashi, Tomoko Urushidate, Genta Nagae, Shogo Yamamoto, Hiroki Ueda, Kenji Tatsuno, Hidenori Ojima, Nobuyoshi Hiraoka, Takuji Okusaka, Michiaki Kubo, Shigeru Marubashi, Terumasa Yamada, Satoshi Hirano, Masakazu Yamamoto, Hideki Ohdan, Kazuaki Shimada, Osamu Ishikawa, Hiroki Yamaue, Kazuki Chayama, Satoru Miyano, Hiroyuki Aburatani, Tatsuhiro Shibata & Hidewaki Nakagawa

Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

Nature Genetics 48, 700 (2016). doi:10.1038/ng0616-700b

Author: Jessica Okosun, Rachel L Wolfson, Jun Wang, Shamzah Araf, Lucy Wilkins, Brian M Castellano, Leire Escudero-Ibarz, Ahad Fahad Al Seraihi, Julia Richter, Stephan H Bernhart, Alejo Efeyan, Sameena Iqbal, Janet Matthews, Andrew Clear, José Afonso Guerra-Assunção, Csaba Bödör, Hilmar Quentmeier, Christopher Mansbridge, Peter Johnson, Andrew Davies, Jonathan C Strefford, Graham Packham, Sharon Barrans, Andrew Jack, Ming-Qing Du, Maria Calaminici, T Andrew Lister, Rebecca Auer, Silvia Montoto, John G Gribben, Reiner Siebert, Claude Chelala, Roberto Zoncu, David M Sabatini & Jude Fitzgibbon

Corrigendum: The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons

Nature Genetics 48, 700 (2016). doi:10.1038/ng0616-700c

Author: Ingo Braasch, Andrew R Gehrke, Jeramiah J Smith, Kazuhiko Kawasaki, Tereza Manousaki, Jeremy Pasquier, Angel Amores, Thomas Desvignes, Peter Batzel, Julian Catchen, Aaron M Berlin, Michael S Campbell, Daniel Barrell, Kyle J Martin, John F Mulley, Vydianathan Ravi, Alison P Lee, Tetsuya Nakamura, Domitille Chalopin, Shaohua Fan, Dustin Wcisel, Cristian Cañestro, Jason Sydes, Felix E G Beaudry, Yi Sun, Jana Hertel, Michael J Beam, Mario Fasold, Mikio Ishiyama, Jeremy Johnson, Steffi Kehr, Marcia Lara, John H Letaw, Gary W Litman, Ronda T Litman, Masato Mikami, Tatsuya Ota, Nil Ratan Saha, Louise Williams, Peter F Stadler, Han Wang, John S Taylor, Quenton Fontenot, Allyse Ferrara, Stephen M J Searle, Bronwen Aken, Mark Yandell, Igor Schneider, Jeffrey A Yoder, Jean-Nicolas Volff, Axel Meyer, Chris T Amemiya, Byrappa Venkatesh, Peter W H Holland, Yann Guiguen, Julien Bobe, Neil H Shubin, Federica Di Palma, Jessica Alfo¨ldi, Kerstin Lindblad-Toh & John H Postlethwait

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

Nature Genetics 48, 607 (2016). doi:10.1038/ng.3564

Authors: Joshua D Campbell, Anton Alexandrov, Jaegil Kim, Jeremiah Wala, Alice H Berger, Chandra Sekhar Pedamallu, Sachet A Shukla, Guangwu Guo, Angela N Brooks, Bradley A Murray, Marcin Imielinski, Xin Hu, Shiyun Ling, Rehan Akbani, Mara Rosenberg, Carrie Cibulskis, Aruna Ramachandran, Eric A Collisson, David J Kwiatkowski, Michael S Lawrence, John N Weinstein, Roel G W Verhaak, Catherine J Wu, Peter S Hammerman, Andrew D Cherniack, Gad Getz, Maxim N Artyomov, Robert Schreiber, Ramaswamy Govindan & Matthew Meyerson

The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery

Nature Genetics 48, 648 (2016). doi:10.1038/ng.3558

Authors: Michinori Toriyama, Chanjae Lee, S Paige Taylor, Ivan Duran, Daniel H Cohn, Ange-Line Bruel, Jacqueline M Tabler, Kevin Drew, Marcus R Kelly, Sukyoung Kim, Tae Joo Park, Daniella Braun, Ghislaine Pierquin, Armand Biver, Kerstin Wagner, Anne Malfroot, Inusha Panigrahi, Brunella Franco, Hadeel Adel Al-lami, Yvonne Yeung, Yeon Ja Choi, Yannis Duffourd, Laurence Faivre, Jean-Baptiste Rivière, Jiang Chen, Karen J Liu, Edward M Marcotte, Friedhelm Hildebrandt, Christel Thauvin-Robinet, Deborah Krakow, Peter K Jackson & John B Wallingford

A high-quality carrot genome assembly provides new insights into carotenoid accumulation and asterid genome evolution

Nature Genetics 48, 657 (2016). doi:10.1038/ng.3565

Authors: Massimo Iorizzo, Shelby Ellison, Douglas Senalik, Peng Zeng, Pimchanok Satapoomin, Jiaying Huang, Megan Bowman, Marina Iovene, Walter Sanseverino, Pablo Cavagnaro, Mehtap Yildiz, Alicja Macko-Podgórni, Emilia Moranska, Ewa Grzebelus, Dariusz Grzebelus, Hamid Ashrafi, Zhijun Zheng, Shifeng Cheng, David Spooner, Allen Van Deynze & Philipp Simon