The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.

TitleThe 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.
Publication TypeJournal Article
Year of Publication2009
AuthorsPomerantz, MM, Ahmadiyeh, N, Jia, L, Herman, P, Verzi, MP, Doddapaneni, H, Beckwith, CA, Chan, JA, Hills, A, Davis, M, Yao, K, Kehoe, SM, Lenz, H-J, Haiman, CA, Yan, C, Henderson, BE, Frenkel, B, Barretina, J, Bass, A, Tabernero, J, Baselga, J, Regan, MM, J Manak, R, Shivdasani, R, Coetzee, GA, Freedman, ML
JournalNat Genet
Volume41
Issue8
Pagination882-4
Date Published2009 Aug
ISSN1546-1718
KeywordsAlleles, Cell Line, Tumor, Chromosomes, Human, Pair 8, Colorectal Neoplasms, Enhancer Elements, Genetic, Genetic Predisposition to Disease, Humans, Polymorphism, Single Nucleotide, Protein Binding, Proto-Oncogene Proteins c-myc, TCF Transcription Factors, Transcription Factor 7-Like 2 Protein
Abstract

An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that the region harboring this variant is a transcriptional enhancer, that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2) and that the risk region physically interacts with the MYC proto-oncogene. These data provide strong support for a biological mechanism underlying this non-protein-coding risk variant.

DOI10.1038/ng.403
Alternate JournalNat. Genet.
PubMed ID19561607
PubMed Central IDPMC2763485
Grant ListP50 CA090381 / CA / NCI NIH HHS / United States
R01 CA129435 / CA / NCI NIH HHS / United States
5P50CA90381 / CA / NCI NIH HHS / United States
R01 CA136924 / CA / NCI NIH HHS / United States
R01 CA109147-04 / CA / NCI NIH HHS / United States
K08 CA134931 / CA / NCI NIH HHS / United States
R01 CA109147 / CA / NCI NIH HHS / United States
/ / Howard Hughes Medical Institute / United States