ADD1 460W allele associated with cardiovascular disease in hypertensive individuals.

TitleADD1 460W allele associated with cardiovascular disease in hypertensive individuals.
Publication TypeJournal Article
Year of Publication2002
AuthorsMorrison, AC, Bray, MS, Folsom, AR, Boerwinkle, E
JournalHypertension
Volume39
Issue6
Pagination1053-7
Date Published2002 Jun
ISSN1524-4563
KeywordsAlleles, Arterial Occlusive Diseases, Calmodulin-Binding Proteins, Cardiovascular Diseases, Case-Control Studies, Coronary Disease, European Continental Ancestry Group, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Heterotrimeric GTP-Binding Proteins, Humans, Hypertension, Incidence, Male, Middle Aged, Polymorphism, Single Nucleotide, Prevalence
Abstract

High blood pressure is a predictor of cardiovascular disease. Hence, genes contributing to essential hypertension may play a role in the etiology of cardiovascular disease. For this reason, we examined the association between the alpha-adducin (ADD1) G460W and G-protein beta3 subunit (GNB3) 825C>T polymorphisms and the prevalence of peripheral arterial disease (PAD) and incidence of coronary heart disease (CHD) in non-Hispanic whites from the Atherosclerosis Risk in Communities (ARIC) Study. PAD prevalence was defined by an ankle-brachial index, ie, the ratio of ankle systolic blood pressure to brachial artery systolic blood pressure, of

Alternate JournalHypertension
PubMed ID12052841
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States