Analysis of the Par2 modifier of pulmonary adenoma formation in mice.

TitleAnalysis of the Par2 modifier of pulmonary adenoma formation in mice.
Publication TypeJournal Article
Year of Publication2005
AuthorsWang, M, Wang, Y, You, M, Devereux, TR
JournalExp Lung Res
Volume31
Issue2
Pagination193-204
Date Published2005 Mar
ISSN0190-2148
KeywordsAdenoma, Amino Acid Sequence, Animals, Chromosome Mapping, Gene Expression, Genetic Predisposition to Disease, Lung Neoplasms, Mice, Molecular Sequence Data, Polymorphism, Genetic, Quantitative Trait Loci
Abstract

Inbred strains of mouse show various susceptibilities to spontaneous and chemical-induced lung tumorigenesis. Genetic analyses have revealed that lung tumor susceptibilities of inbred mouse strains are governed by quantitative trait loci (QLTs) located on multiple chromosomes. A major lung tumor resistance QLT, designated pulmonary adenoma resistance 2 (Par2), was mapped to the mouse chromosome 18 independently by several groups and accounted for up to 60% phenotype variance between susceptible A/J and more resistant BALB/c strains. The authors recently conducted studies to positionally clone the Par2 gene. This review summarizes the effort and progress towards the identification of Par2 candidates.

Alternate JournalExp. Lung Res.
PubMed ID15828125
Grant ListR01CA099147 / CA / NCI NIH HHS / United States
R01CA58554 / CA / NCI NIH HHS / United States