Androgen receptor CAG repeat polymorphism in males of six non-human primate species.

TitleAndrogen receptor CAG repeat polymorphism in males of six non-human primate species.
Publication TypeJournal Article
Year of Publication2012
AuthorsMubiru, JN, Cavazos, N, Hemmat, P, Garcia-Forey, M, Shade, RE, Rogers, J
JournalJ Med Primatol
Volume41
Issue1
Pagination67-70
Date Published2012 Feb
ISSN1600-0684
KeywordsAnimals, DNA, Male, Pan troglodytes, Polymerase Chain Reaction, Polymorphism, Genetic, Primates, Receptors, Androgen, Trinucleotide Repeats
Abstract

BACKGROUND: Androgen receptor [CAG](n) microsatellite has been linked to human diseases.METHODS: Six non-human primates were genotyped for the [CAG](n) microsatellite.RESULTS: Marmosets and macaques are monomorphic, while mangabeys, baboons, and chimpanzees are polymorphic.CONCLUSIONS: Non-human primates that are polymorphic for the microsatellite are candidate animal models for CAG-related diseases.

DOI10.1111/j.1600-0684.2011.00517.x
Alternate JournalJ. Med. Primatol.
PubMed ID21978295
PubMed Central IDPMC3479659
Grant ListK01 RR025161 / RR / NCRR NIH HHS / United States
K01RR025161-01 / RR / NCRR NIH HHS / United States
RR013556 / RR / NCRR NIH HHS / United States
C06 RR013556 / RR / NCRR NIH HHS / United States
K01 OD010973 / OD / NIH HHS / United States
P51 RR0139986 / RR / NCRR NIH HHS / United States
P51 RR013986 / RR / NCRR NIH HHS / United States