APOA5 polymorphisms influence plasma triglycerides in young, healthy African Americans and whites of the CARDIA Study.

TitleAPOA5 polymorphisms influence plasma triglycerides in young, healthy African Americans and whites of the CARDIA Study.
Publication TypeJournal Article
Year of Publication2005
AuthorsKlos, KLE, Hamon, S, Clark, AG, Boerwinkle, E, Liu, K, Sing, CF
JournalJ Lipid Res
Volume46
Issue3
Pagination564-71
Date Published2005 Mar
ISSN0022-2275
KeywordsAdolescent, Adult, African Americans, Alleles, Apolipoprotein A-V, Apolipoproteins, Apolipoproteins A, Cohort Studies, Coronary Artery Disease, Cross-Sectional Studies, European Continental Ancestry Group, Female, Genetic Variation, Genotype, Humans, Male, Polymorphism, Genetic, Risk Factors, Sex Factors, Triglycerides, United States
Abstract

Genetic variation in the apolipoprotein A-V gene (APOA5) has been associated with variation in plasma triglyceride (TG) levels in African American and white females and males older than 40 years and/or at increased risk of coronary artery disease. We have examined whether plasma TG levels are associated with 16 APOA5 polymorphisms in young (18-30 years) African American (1,075 females and 783 males) and white (1,041 females and 932 males) individuals of the Coronary Artery Risk Development in Young Adults (CARDIA) Study selected without regard to health. Plasma TG was significantly (P < 0.01) associated with markers 27376 and 28837 (-3A/G) in both white females and males, with 27709 (-1131T/C) and 29085 in white males, with 29009 (S19W) in African American females and white males, and with 30966 in African American females. No statistically significant associations were observed in African American males. These six single-nucleotide polymorphisms individually accounted for 0-0.78% of lnTG variation among white females, 0-2.46% among white males, and 0-0.69% among African American females. The results of our study suggest a small but replicable context-dependent influence of the APOA5 gene region on plasma TG levels in young, healthy individuals.

DOI10.1194/jlr.M400437-JLR200
Alternate JournalJ. Lipid Res.
PubMed ID15604515
Grant ListGM-65509 / GM / NIGMS NIH HHS / United States
HL-39107 / HL / NHLBI NIH HHS / United States
HL-51021 / HL / NHLBI NIH HHS / United States
HL-72905 / HL / NHLBI NIH HHS / United States
N01-HC-48047 / HC / NHLBI NIH HHS / United States
N01-HC-48048 / HC / NHLBI NIH HHS / United States
N01-HC-48049 / HC / NHLBI NIH HHS / United States
N01-HC-48050 / HC / NHLBI NIH HHS / United States
N01-HC-95095 / HC / NHLBI NIH HHS / United States