|Title||Association between mitochondrial DNA copy number and sudden cardiac death: findings from the Atherosclerosis Risk in Communities study (ARIC).|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Zhang, Y, Guallar, E, Ashar, FN, Longchamps, RJ, Castellani, CA, Lane, J, Grove, ML, Coresh, J, Sotoodehnia, N, Ilkhanoff, L, Boerwinkle, E, Pankratz, N, Arking, DE|
|Journal||Eur Heart J|
|Date Published||2017 Jun 30|
Aims: Sudden cardiac death (SCD) is a major public health burden. Mitochondrial dysfunction has been implicated in a wide range of cardiovascular diseases including cardiomyopathy, heart failure, and arrhythmias, but it is unknown if it also contributes to SCD risk. We sought to examine the prospective association between mtDNA copy number (mtDNA-CN), a surrogate marker of mitochondrial function, and SCD risk.
Methods and results: We measured baseline mtDNA-CN in 11 093 participants from the Atherosclerosis Risk in Communities (ARIC) study. mtDNA copy number was calculated from probe intensities of mitochondrial single nucleotide polymorphisms (SNP) on the Affymetrix Genome-Wide Human SNP Array 6.0. Sudden cardiac death was defined as a sudden pulseless condition presumed due to a ventricular tachyarrhythmia in a previously stable individual without evidence of a non-cardiac cause of cardiac arrest. Sudden cardiac death cases were reviewed and adjudicated by an expert committee. During a median follow-up of 20.4 years, we observed 361 SCD cases. After adjusting for age, race, sex, and centre, the hazard ratio for SCD comparing the 1st to the 5th quintiles of mtDNA-CN was 2.24 (95% confidence interval 1.58-3.19; P-trend
Conclusion: In this community-based prospective study, mtDNA-CN in peripheral blood was inversely associated with the risk of SCD.
|Alternate Journal||Eur. Heart J.|
|Grant List||T32 GM007814 / GM / NIGMS NIH HHS / United States|