Association of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's Disease Sequencing Project.

TitleAssociation of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's Disease Sequencing Project.
Publication TypeJournal Article
Year of Publication2023
AuthorsLee, W-P, Choi, SHoan, Shea, MG, Cheng, P-L, Dombroski, BA, Pitsillides, AN, Heard-Costa, NL, Wang, H, Bulekova, K, Kuzma, AB, Leung, YYee, Farrell, JJ, Lin, H, Naj, A, Blue, EE, Nusetor, F, Wang, D, Boerwinkle, E, Bush, WS, Zhang, X, De Jager, PL, Dupuis, J, Farrer, LA, Fornage, M, Martin, E, Pericak-Vance, M, Seshadri, S, Wijsman, EM, San Wang, L-, Schellenberg, GD, DeStefano, AL, Haines, JL, Peloso, GM
JournalmedRxiv
Date Published2023 Sep 02
Abstract

Alzheimer's Disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous. Here, we investigated the association between AD and both common variants and aggregates of rare coding and noncoding variants in 13,371 individuals of diverse ancestry with whole genome sequence (WGS) data. Pooled-population analyses identified genetic variants in or near , , and significantly associated with AD (p

DOI10.1101/2023.09.01.23294953
Alternate JournalmedRxiv
PubMed ID37693521
PubMed Central IDPMC10491367
Grant ListU01 AG032984 / AG / NIA NIH HHS / United States
P30 AG072978 / AG / NIA NIH HHS / United States
U24 AG041689 / AG / NIA NIH HHS / United States
U01 AG058589 / AG / NIA NIH HHS / United States
R01 AG072547 / AG / NIA NIH HHS / United States
P30 AG066509 / AG / NIA NIH HHS / United States
U01 AG062602 / AG / NIA NIH HHS / United States
U01 AG058654 / AG / NIA NIH HHS / United States
U01 AG068221 / AG / NIA NIH HHS / United States
U54 AG052427 / AG / NIA NIH HHS / United States
U01 AG072577 / AG / NIA NIH HHS / United States
RF1 AG074328 / AG / NIA NIH HHS / United States
R01 AG048927 / AG / NIA NIH HHS / United States
R01 AG080810 / AG / NIA NIH HHS / United States
R01 AG070864 / AG / NIA NIH HHS / United States
U19 AG068753 / AG / NIA NIH HHS / United States
P30 AG072979 / AG / NIA NIH HHS / United States