Association of mitochondrial DNA copy number with cardiometabolic diseases.

TitleAssociation of mitochondrial DNA copy number with cardiometabolic diseases.
Publication TypeJournal Article
Year of Publication2021
AuthorsLiu, X, Longchamps, RJ, Wiggins, KL, Raffield, LM, Bielak, LF, Zhao, W, Pitsillides, A, Blackwell, TW, Yao, J, Guo, X, Kurniansyah, N, Thyagarajan, B, Pankratz, N, Rich, SS, Taylor, KD, Peyser, PA, Heckbert, SR, Seshadri, S, L Cupples, A, Boerwinkle, E, Grove, ML, Larson, NB, Smith, JA, Vasan, RS, Sofer, T, Fitzpatrick, AL, Fornage, M, Ding, J, Correa, A, Abecasis, G, Psaty, BM, Wilson, JG, Levy, D, Rotter, JI, Bis, JC, Satizabal, CL, Arking, DE, Liu, C
Corporate AuthorsTOPMed mtDNA Working Group in NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
JournalCell Genom
Volume1
Issue1
Date Published2021 Oct 13
ISSN2666-979X
Abstract

Mitochondrial DNA (mtDNA) is present in multiple copies in human cells. We evaluated cross-sectional associations of whole blood mtDNA copy number (CN) with several cardiometabolic disease traits in 408,361 participants of multiple ancestries in TOPMed and UK Biobank. Age showed a threshold association with mtDNA CN: among younger participants (
DOI10.1016/j.xgen.2021.100006
Alternate JournalCell Genom
PubMed ID35036986
PubMed Central IDPMC8758111
Grant ListMC_PC_17228 / MRC_ / Medical Research Council / United Kingdom
R01 HL120393 / HL / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
HHSN268201800001C / HL / NHLBI NIH HHS / United States
R01 AG059727 / AG / NIA NIH HHS / United States
CH/1996001/9454 / BHF_ / British Heart Foundation / United Kingdom
R01 HL144569 / HL / NHLBI NIH HHS / United States
R01 HL131573 / HL / NHLBI NIH HHS / United States
R01 HL117626 / HL / NHLBI NIH HHS / United States
MC_QA137853 / MRC_ / Medical Research Council / United Kingdom
R01 HL155569 / HL / NHLBI NIH HHS / United States