Title | Association of sickle cell trait with measures of cognitive function and dementia in African Americans. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Chen, N, Caruso, C, Alonso, A, Derebail, VK, Kshirsagar, AV, A Sharrett, R, Key, NS, Gottesman, RF, Grove, ML, Bressler, J, Boerwinkle, E, B Windham, G, Mosley, TH, Hyacinth, HI |
Journal | eNeurologicalSci |
Volume | 16 |
Pagination | 100201 |
Date Published | 2019 Sep |
ISSN | 2405-6502 |
Abstract | OBJECTIVE: The incidence and prevalence of cognitive decline and dementia are significantly higher among African Americans compared with non-Hispanic Whites. The aim of this study was to determine whether inheritance of the sickle cell trait (SCT) i.e. heterozygosity for the sickle cell mutation increases the risk of cognitive decline or dementia Among African Americans.METHODS: We studied African American participants enrolled in the Atherosclerosis Risk in Communities study. SCT genotype at baseline and outcome data from cognitive assessments at visits 2, 4 and 5, and an MRI performed at visit 5 were analyzed for the association between SCT and risk of cognitive impairment and/or dementia.RESULTS: There was no significant difference in risk factors profile between participants with SCT ( = 176) and those without SCT ( = 2532). SCT was not independently associated with a higher prevalence of global or domain-specific cognitive impairment at baseline or with more rapid cognitive decline. Participants with SCT had slightly lower incidence of dementia (HR = 0.63 [0.38, 1.05]). On the other hand, SCT seems to interact with the apolipoprotein E ε4 risk allele resulting in poor performance on digit symbol substitution test at baseline (z-score = -0.08, P = 0.05) and over time (z-score = -0.12, P = 0.04); and with diabetes mellitus leading to a moderately increased risk of dementia (HR = 2.06 [0.89, 4.78], P = 0.01).CONCLUSIONS: SCT was not an independent risk factor for prevalence or incidence of cognitive decline or dementia, although it may interact with and modify other putative risk factors for cognitive decline and dementia. |
DOI | 10.1016/j.ensci.2019.100201 |
Alternate Journal | eNeurologicalSci |
PubMed ID | 31384675 |
PubMed Central ID | PMC6661502 |
Grant List | U01 HL096812 / HL / NHLBI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States K12 HL087097 / HL / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States HHSN268201700002C / HL / NHLBI NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States R01 HL138423 / HL / NHLBI NIH HHS / United States R01 HL070825 / HL / NHLBI NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States K24 HL148521 / HL / NHLBI NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States HHSN268201700005C / HL / NHLBI NIH HHS / United States HHSN268201700001C / HL / NHLBI NIH HHS / United States HHSN268201700003C / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States HHSN268201700004C / HL / NHLBI NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States U01 HL117721 / HL / NHLBI NIH HHS / United States |