Associations between metabolomic compounds and incident heart failure among African Americans: the ARIC Study.

TitleAssociations between metabolomic compounds and incident heart failure among African Americans: the ARIC Study.
Publication TypeJournal Article
Year of Publication2013
AuthorsZheng, Y, Yu, B, Alexander, D, Manolio, TA, Aguilar, D, Coresh, J, Heiss, G, Boerwinkle, E, Nettleton, JA
JournalAm J Epidemiol
Volume178
Issue4
Pagination534-42
Date Published2013 Aug 15
ISSN1476-6256
KeywordsAfrican Americans, Age Distribution, Atherosclerosis, Biomarkers, Comorbidity, Diabetes Mellitus, Female, Follow-Up Studies, Heart Failure, Humans, Hypertension, Kidney Diseases, Male, Metabolomics, Middle Aged, Mississippi, Obesity, Proportional Hazards Models, Sedentary Lifestyle
Abstract

Heart failure is more prevalent among African Americans than in the general population. Metabolomic studies among African Americans may efficiently identify novel biomarkers of heart failure. We used untargeted methods to measure 204 stable serum metabolites and evaluated their associations with incident heart failure hospitalization (n = 276) after a median follow-up of 20 years (1987-2008) by using Cox regression in data from 1,744 African Americans aged 45-64 years without heart failure at baseline from the Jackson, Mississippi, field center of the Atherosclerosis Risk in Communities (ARIC) Study. After adjustment for established risk factors, we found that 16 metabolites (6 named with known structural identities and 10 unnamed with unknown structural identities, the latter denoted by using the format X-12345) were associated with incident heart failure (P

DOI10.1093/aje/kwt004
Alternate JournalAm. J. Epidemiol.
PubMed ID23788672
PubMed Central IDPMC3736751
Grant List3U01HG004402-02S1 / HG / NHGRI NIH HHS / United States
5K01DK082729-04 / DK / NIDDK NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
K01 DK082729 / DK / NIDDK NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States