|Title||Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Sá, ACaroline C, Webb, A, Gong, Y, McDonough, CW, Shahin, MH, Datta, S, Langaee, TY, Turner, ST, Beitelshees, AL, Chapman, AB, Boerwinkle, E, Gums, JG, Scherer, SE, Cooper-Dehoff, RM, Sadee, W, Johnson, JA|
|Journal||BMC Med Genomics|
|Date Published||2018 Jun 20|
|Keywords||Antihypertensive Agents, Blood Pressure, Female, Gene Expression Profiling, Humans, Hypertension, Male, Middle Aged, Pharmacogenomic Testing, Sodium Chloride Symporter Inhibitors|
BACKGROUND: Recently, 34 genes had been associated with differential expression relative to blood pressure (BP)/ hypertension (HTN). We hypothesize that some of the genes associated with BP/HTN are also associated with BP response to antihypertensive treatment with thiazide diuretics.
METHODS: We assessed these 34 genes for association with differential expression to BP response to thiazide diuretics with RNA sequencing in whole blood samples from 150 hypertensive participants from the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) and PEAR-2 studies. PEAR white and PEAR-2 white and black participants (n = 50 for each group) were selected based on the upper and lower quartile of BP response to hydrochlorothiazide (HCTZ) and to chlorthalidone.
RESULTS: FOS, DUSP1 and PPP1R15A were differentially expressed across all cohorts (meta-analysis p-value
CONCLUSIONS: These findings suggest FOS, DUSP1 and PPP1R15A as potential molecular determinants of antihypertensive response to thiazide diuretics.
TRIAL REGISTRATION: NCT00246519 , NCT01203852 www.clinicaltrials.gov.
|Alternate Journal||BMC Med Genomics|
|PubMed Central ID||PMC6011347|
|Grant List||U19 GM061388 / GM / NIGMS NIH HHS / United States |
UL1 TR000064 / TR / NCATS NIH HHS / United States
U01 GM074492 / GM / NIGMS NIH HHS / United States
UL1 TR001427 / TR / NCATS NIH HHS / United States
UL1 TR000135 / TR / NCATS NIH HHS / United States
UL1 TR000454 / TR / NCATS NIH HHS / United States
UL1 TR002378 / TR / NCATS NIH HHS / United States
U19 GM061390 / GM / NIGMS NIH HHS / United States