Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.

TitleBlood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.
Publication TypeJournal Article
Year of Publication2018
AuthorsSá, ACaroline C, Webb, A, Gong, Y, McDonough, CW, Shahin, MH, Datta, S, Langaee, TY, Turner, ST, Beitelshees, AL, Chapman, AB, Boerwinkle, E, Gums, JG, Scherer, SE, Cooper-Dehoff, RM, Sadee, W, Johnson, JA
JournalBMC Med Genomics
Volume11
Issue1
Pagination55
Date Published2018 Jun 20
ISSN1755-8794
Abstract

BACKGROUND: Recently, 34 genes had been associated with differential expression relative to blood pressure (BP)/ hypertension (HTN). We hypothesize that some of the genes associated with BP/HTN are also associated with BP response to antihypertensive treatment with thiazide diuretics.

METHODS: We assessed these 34 genes for association with differential expression to BP response to thiazide diuretics with RNA sequencing in whole blood samples from 150 hypertensive participants from the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) and PEAR-2 studies. PEAR white and PEAR-2 white and black participants (n = 50 for each group) were selected based on the upper and lower quartile of BP response to hydrochlorothiazide (HCTZ) and to chlorthalidone.

RESULTS: FOS, DUSP1 and PPP1R15A were differentially expressed across all cohorts (meta-analysis p-value

CONCLUSIONS: These findings suggest FOS, DUSP1 and PPP1R15A as potential molecular determinants of antihypertensive response to thiazide diuretics.

TRIAL REGISTRATION: NCT00246519 , NCT01203852 www.clinicaltrials.gov.

DOI10.1186/s12920-018-0370-x
Alternate JournalBMC Med Genomics
PubMed ID29925376
PubMed Central IDPMC6011347
Grant ListU19 GM061388 / GM / NIGMS NIH HHS / United States
U19-GM061390 / / National Institutes of Health Pharmacogenetics Research Network /
UL1 TR000064 / TR / NCATS NIH HHS / United States
U01-GM074492 / / National Institute of Health Pharmacogenetics Research Network /
U01 GM074492 / GM / NIGMS NIH HHS / United States
UL1 TR000064 / / National Center for Advancing Translational Sciences /
UL1 TR000454 / / National Center for Advancing Translational Sciences /
UL1 TR000135 / TR / NCATS NIH HHS / United States
UL1 TR000454 / TR / NCATS NIH HHS / United States
U19 GM061390 / GM / NIGMS NIH HHS / United States
UL1 TR000135 / / National Center for Advancing Translational Sciences /
U19-GM061388 / / National Institutes of Health Pharmacogenetics Research Network /