The Cancer Genome Atlas Pan-Cancer analysis project.

TitleThe Cancer Genome Atlas Pan-Cancer analysis project.
Publication TypeJournal Article
Year of Publication2013
AuthorsWeinstein, JN, Collisson, EA, Mills, GB, Shaw, KRMills, Ozenberger, BA, Ellrott, K, Shmulevich, I, Sander, C, Stuart, JM
Corporate AuthorsCancer Genome Atlas Research Network
JournalNat Genet
Volume45
Issue10
Pagination1113-20
Date Published2013 Oct
ISSN1546-1718
KeywordsGene Expression Profiling, Genome, Humans, Neoplasms
Abstract

The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile.

DOI10.1038/ng.2764
Alternate JournalNat. Genet.
PubMed ID24071849
PubMed Central IDPMC3919969
Grant ListP30 CA016672 / CA / NCI NIH HHS / United States
U24 CA143882 / CA / NCI NIH HHS / United States
U24 CA143835 / CA / NCI NIH HHS / United States
K08 CA137153 / CA / NCI NIH HHS / United States
P50 CA098258 / CA / NCI NIH HHS / United States
U01 CA168394 / CA / NCI NIH HHS / United States
R01 HG005690 / HG / NHGRI NIH HHS / United States
P30 CA008748 / CA / NCI NIH HHS / United States
U24 CA143840 / CA / NCI NIH HHS / United States
U24 CA143858 / CA / NCI NIH HHS / United States
P01 CA101937 / CA / NCI NIH HHS / United States
P50 CA083639 / CA / NCI NIH HHS / United States
R01 CA180778 / CA / NCI NIH HHS / United States
U24 CA143883 / CA / NCI NIH HHS / United States