| Title | The Cancer Genome Atlas Pan-Cancer analysis project. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Weinstein, JN, Collisson, EA, Mills, GB, Shaw, KRMills, Ozenberger, BA, Ellrott, K, Shmulevich, I, Sander, C, Stuart, JM |
| Corporate Authors | Cancer Genome Atlas Research Network |
| Journal | Nat Genet |
| Volume | 45 |
| Issue | 10 |
| Pagination | 1113-20 |
| Date Published | 2013 Oct |
| ISSN | 1546-1718 |
| Keywords | Gene Expression Profiling, Genome, Humans, Neoplasms |
| Abstract | The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. |
| DOI | 10.1038/ng.2764 |
| Alternate Journal | Nat. Genet. |
| PubMed ID | 24071849 |
| PubMed Central ID | PMC3919969 |
| Grant List | P30 CA016672 / CA / NCI NIH HHS / United States U24 CA143882 / CA / NCI NIH HHS / United States U24 CA143835 / CA / NCI NIH HHS / United States K08 CA137153 / CA / NCI NIH HHS / United States P50 CA098258 / CA / NCI NIH HHS / United States U01 CA168394 / CA / NCI NIH HHS / United States R01 HG005690 / HG / NHGRI NIH HHS / United States P30 CA008748 / CA / NCI NIH HHS / United States U24 CA143840 / CA / NCI NIH HHS / United States U24 CA143858 / CA / NCI NIH HHS / United States P01 CA101937 / CA / NCI NIH HHS / United States P50 CA083639 / CA / NCI NIH HHS / United States R01 CA180778 / CA / NCI NIH HHS / United States U24 CA143883 / CA / NCI NIH HHS / United States |