| Title | Change in Neutrophil-to-lymphocyte ratio (NLR) in response to immune checkpoint blockade for metastatic renal cell carcinoma. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Lalani, A-KA, Xie, W, Martini, DJ, Steinharter, JA, Norton, CK, Krajewski, KM, Duquette, A, Bossé, D, Bellmunt, J, Van Allen, EM, McGregor, BA, Creighton, CJ, Harshman, LC, Choueiri, TK |
| Journal | J Immunother Cancer |
| Volume | 6 |
| Issue | 1 |
| Pagination | 5 |
| Date Published | 2018 01 22 |
| ISSN | 2051-1426 |
| Keywords | Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Immunological, B7-H1 Antigen, Carcinoma, Renal Cell, Female, Humans, Kidney Neoplasms, Lymphocytes, Male, Middle Aged, Neutrophils, Programmed Cell Death 1 Receptor, Survival Analysis, Treatment Outcome, Young Adult |
| Abstract | BACKGROUND: An elevated Neutrophil-to-lymphocyte ratio (NLR) is associated with worse outcomes in several malignancies. However, its role with contemporary immune checkpoint blockade (ICB) is unknown. We investigated the utility of NLR in metastatic renal cell carcinoma (mRCC) patients treated with PD-1/PD-L1 ICB. METHODS: We examined NLR at baseline and 6 (±2) weeks later in 142 patients treated between 2009 and 2017 at Dana-Farber Cancer Institute (Boston, USA). Landmark analysis at 6 weeks was conducted to explore the prognostic value of relative NLR change on overall survival (OS), progression-free survival (PFS), and objective response rate (ORR). Cox and logistic regression models allowed for adjustment of line of therapy, number of IMDC risk factors, histology and baseline NLR. RESULTS: Median follow up was 16.6 months (range: 0.7-67.8). Median duration on therapy was 5.1 months ( CONCLUSIONS: Early decline and NLR at 6 weeks are associated with significantly improved outcomes in mRCC patients treated with ICB. The prognostic value of the readily-available NLR warrants larger, prospective validation. |
| DOI | 10.1186/s40425-018-0315-0 |
| Alternate Journal | J Immunother Cancer |
| PubMed ID | 29353553 |
| PubMed Central ID | PMC5776777 |
| Grant List | Kidney Spore / / Foundation for the National Institutes of Health / United States |