Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".

TitleComment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".
Publication TypeJournal Article
Year of Publication2007
AuthorsYu, F, R Hill, S, Schaffner, SF, Sabeti, PC, Wang, ET, Mignault, AA, Ferland, RJ, Moyzis, RK, Walsh, CA, Reich, D
JournalScience
Volume316
Issue5823
Pagination370
Date Published2007 Apr 20
ISSN1095-9203
KeywordsAdaptation, Biological, African Continental Ancestry Group, Asian Continental Ancestry Group, Biological Evolution, Brain, European Continental Ancestry Group, Gene Frequency, Haplotypes, Humans, Nerve Tissue Proteins, Polymorphism, Single Nucleotide, Recombination, Genetic, Selection, Genetic, Sequence Analysis, DNA, Time
Abstract

Mekel-Bobrov et al. (Reports, 9 September 2005, p. 1720) suggested that ASPM, a gene associated with microcephaly, underwent natural selection within the last 500 to 14,100 years. Their analyses based on comparison with computer simulations indicated that ASPM had an unusual pattern of variation. However, when we compare ASPM empirically to a large number of other loci, its variation is not unusual and does not support selection.

DOI10.1126/science.1137568
Alternate JournalScience
PubMed ID17446375