The common marmoset genome provides insight into primate biology and evolution.

TitleThe common marmoset genome provides insight into primate biology and evolution.
Publication TypeJournal Article
Year of Publication2014
Corporate Authors
JournalNat Genet
Volume46
Issue8
Pagination850-7
Date Published2014 Aug
ISSN1546-1718
KeywordsAmino Acid Sequence, Animals, Callithrix, Evolution, Molecular, Female, Genome, MicroRNAs, Molecular Sequence Data, Phylogeny, Polymorphism, Single Nucleotide, Reproduction, Sequence Analysis, DNA
Abstract

We report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6×) and a whole-genome shotgun strategy. A first analysis has permitted comparison with the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the unique biology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism. We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex I genes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways). In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution. This genome sequence for a New World monkey enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application.

DOI10.1038/ng.3042
Alternate JournalNat. Genet.
PubMed ID25038751
PubMed Central IDPMC4138798
Grant List095908 / / Wellcome Trust / United Kingdom
260372 / / European Research Council / International
K99 HG005846 / HG / NHGRI NIH HHS / United States
P51 OD011133 / OD / NIH HHS / United States
R01 DK077639 / DK / NIDDK NIH HHS / United States
R01 GM059290 / GM / NIGMS NIH HHS / United States
R01 HG002385 / HG / NHGRI NIH HHS / United States
U41 HG002371 / HG / NHGRI NIH HHS / United States
U54 HG003079 / HG / NHGRI NIH HHS / United States
U54 HG003273 / HG / NHGRI NIH HHS / United States
/ / Howard Hughes Medical Institute / United States