The comparative genomics and complex population history of baboons.

TitleThe comparative genomics and complex population history of baboons.
Publication TypeJournal Article
Year of Publication2019
AuthorsRogers, J, Raveendran, M, Harris, RA, Mailund, T, Leppälä, K, Athanasiadis, G, Schierup, MHeide, Cheng, J, Munch, K, Walker, JA, Konkel, MK, Jordan, V, Steely, CJ, Beckstrom, TO, Bergey, C, Burrell, A, Schrempf, D, Noll, A, Kothe, M, Kopp, GH, Liu, Y, Murali, S, Billis, K, Martin, FJ, Muffato, M, Cox, L, Else, J, Disotell, T, Muzny, DM, Phillips-Conroy, J, Aken, B, Eichler, EE, Marques-Bonet, T, Kosiol, C, Batzer, MA, Hahn, MW, Tung, J, Zinner, D, Roos, C, Jolly, CJ, Gibbs, RA, Worley, KC
Corporate AuthorsBaboon Genome Analysis Consortium
JournalSci Adv
Volume5
Issue1
Paginationeaau6947
Date Published2019 01
ISSN2375-2548
KeywordsAnimals, Base Sequence, Biological Evolution, Female, Gene Flow, Genomics, Haplotypes, Humans, Hybridization, Genetic, Male, Papio, Phylogeny, Polymorphism, Genetic, Whole Genome Sequencing
Abstract

Recent studies suggest that closely related species can accumulate substantial genetic and phenotypic differences despite ongoing gene flow, thus challenging traditional ideas regarding the genetics of speciation. Baboons (genus ) are Old World monkeys consisting of six readily distinguishable species. Baboon species hybridize in the wild, and prior data imply a complex history of differentiation and introgression. We produced a reference genome assembly for the olive baboon () and whole-genome sequence data for all six extant species. We document multiple episodes of admixture and introgression during the radiation of baboons, thus demonstrating their value as a model of complex evolutionary divergence, hybridization, and reticulation. These results help inform our understanding of similar cases, including modern humans, Neanderthals, Denisovans, and other ancient hominins.

DOI10.1126/sciadv.aau6947
Alternate JournalSci Adv
PubMed ID30854422
PubMed Central IDPMC6401983
Grant ListP51 OD011133 / OD / NIH HHS / United States