| Title | Comparative molecular genomic analyses of a spontaneous rhesus macaque model of mismatch repair-deficient colorectal cancer. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Lermi, NOzirmak, Gray, SB, Bowen, CM, Reyes-Uribe, L, Dray, BK, Deng, N, Harris, RA, Raveendran, M, Benavides, F, Hodo, CL, Taggart, MW, Maresso, KColbert, Sinha, KM, Rogers, J, Vilar, E |
| Journal | PLoS Genet |
| Volume | 18 |
| Issue | 4 |
| Pagination | e1010163 |
| Date Published | 2022 Apr |
| ISSN | 1553-7404 |
| Keywords | Animals, Colonic Neoplasms, Colorectal Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA Methylation, DNA Mismatch Repair, Genomics, Humans, Macaca mulatta, Mice, Microsatellite Instability, MutL Protein Homolog 1 |
| Abstract | Colorectal cancer (CRC) remains the third most common cancer in the US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation of the MLH1 promoter. A cohort of rhesus macaques from our institution developed spontaneous mismatch repair deficient (MMRd) CRC with a notable fraction harboring a pathogenic germline mutation in MLH1 (c.1029C |
| DOI | 10.1371/journal.pgen.1010163 |
| Alternate Journal | PLoS Genet |
| PubMed ID | 35446842 |
| PubMed Central ID | PMC9064097 |
| Grant List | P30 CA016672 / CA / NCI NIH HHS / United States |