Comparative primate genomics: emerging patterns of genome content and dynamics.

TitleComparative primate genomics: emerging patterns of genome content and dynamics.
Publication TypeJournal Article
Year of Publication2014
AuthorsRogers, J, Gibbs, RA
JournalNat Rev Genet
Volume15
Issue5
Pagination347-59
Date Published2014 May
ISSN1471-0064
KeywordsAnimals, Base Sequence, Evolution, Molecular, Genetic Speciation, Genetic Variation, Genome, Genome, Human, Genomics, Humans, Primates
Abstract

Advances in genome sequencing technologies have created new opportunities for comparative primate genomics. Genome assemblies have been published for various primate species, and analyses of several others are underway. Whole-genome assemblies for the great apes provide remarkable new information about the evolutionary origins of the human genome and the processes involved. Genomic data for macaques and other non-human primates offer valuable insights into genetic similarities and differences among species that are used as models for disease-related research. This Review summarizes current knowledge regarding primate genome content and dynamics, and proposes a series of goals for the near future.

DOI10.1038/nrg3707
Alternate JournalNat. Rev. Genet.
PubMed ID24709753
PubMed Central IDPMC4113315
Grant ListR24‑OD011173 / OD / NIH HHS / United States
U54 HG003273 / HG / NHGRI NIH HHS / United States
U54‑HG006484 / HG / NHGRI NIH HHS / United States
R24 RR032329 / RR / NCRR NIH HHS / United States
R24 OD011173 / OD / NIH HHS / United States