Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.

TitleComparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.
Publication TypeJournal Article
Year of Publication2004
AuthorsSeshadri, R, Myers, GSA, Tettelin, H, Eisen, JA, Heidelberg, JF, Dodson, RJ, Davidsen, TM, DeBoy, RT, Fouts, DE, Haft, DH, Selengut, J, Ren, Q, Brinkac, LM, Madupu, R, Kolonay, J, Durkin, SA, Daugherty, SC, Shetty, J, Shvartsbeyn, A, Gebregeorgis, E, Geer, K, Tsegaye, G, Malek, J, Ayodeji, B, Shatsman, S, McLeod, MP, Smajs, D, Howell, JK, Pal, S, Amin, A, Vashisth, P, McNeill, TZ, Xiang, Q, Sodergren, E, Baca, E, Weinstock, GM, Norris, SJ, Fraser, CM, Paulsen, IT
JournalProc Natl Acad Sci U S A
Volume101
Issue15
Pagination5646-51
Date Published2004 Apr 13
ISSN0027-8424
KeywordsATP-Binding Cassette Transporters, Bacterial Proteins, Base Sequence, Borrelia burgdorferi, Genes, Bacterial, Genome, Bacterial, Leptospira interrogans, Models, Genetic, Molecular Sequence Data, Mouth, Sequence Homology, Amino Acid, Treponema, Treponema pallidum
Abstract

We present the complete 2,843,201-bp genome sequence of Treponema denticola (ATCC 35405) an oral spirochete associated with periodontal disease. Analysis of the T. denticola genome reveals factors mediating coaggregation, cell signaling, stress protection, and other competitive and cooperative measures, consistent with its pathogenic nature and lifestyle within the mixed-species environment of subgingival dental plaque. Comparisons with previously sequenced spirochete genomes revealed specific factors contributing to differences and similarities in spirochete physiology as well as pathogenic potential. The T. denticola genome is considerably larger in size than the genome of the related syphilis-causing spirochete Treponema pallidum. The differences in gene content appear to be attributable to a combination of three phenomena: genome reduction, lineage-specific expansions, and horizontal gene transfer. Genes lost due to reductive evolution appear to be largely involved in metabolism and transport, whereas some of the genes that have arisen due to lineage-specific expansions are implicated in various pathogenic interactions, and genes acquired via horizontal gene transfer are largely phage-related or of unknown function.

DOI10.1073/pnas.0307639101
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID15064399
PubMed Central IDPMC397461
Grant ListR01-DE12488 / DE / NIDCR NIH HHS / United States