Complete genome sequence of Treponema pallidum strain DAL-1.

TitleComplete genome sequence of Treponema pallidum strain DAL-1.
Publication TypeJournal Article
Year of Publication2012
AuthorsZobaníková, M, Mikolka, P, Čejková, D, Pospíšilová, P, Chen, L, Strouhal, M, Qin, X, Weinstock, GM, Smajs, D
JournalStand Genomic Sci
Volume7
Issue1
Pagination12-21
Date Published2012 Oct 10
ISSN1944-3277
Abstract

Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.
DOI10.4056/sigs.2615838
Alternate JournalStand Genomic Sci
PubMed ID23449808
PubMed Central IDPMC3570794
Grant ListR01 DA013759 / DA / NIDA NIH HHS / United States
R01 EY013759 / EY / NEI NIH HHS / United States