Conservation of human chromosome 18 in baboons (Papio hamadryas): a linkage map of eight human microsatellites.

TitleConservation of human chromosome 18 in baboons (Papio hamadryas): a linkage map of eight human microsatellites.
Publication TypeJournal Article
Year of Publication1996
AuthorsPerelygin, AA, Kammerer, CM, Stowell, NC, Rogers, J
JournalCytogenet Cell Genet
Volume75
Issue4
Pagination207-9
Date Published1996
ISSN0301-0171
KeywordsAnimals, Chromosomes, Human, Pair 18, Evolution, Molecular, Female, Hominidae, Humans, Lod Score, Male, Microsatellite Repeats, Papio, Pedigree, Phylogeny, Polymerase Chain Reaction, Recombination, Genetic, Species Specificity
Abstract

A panel of 25 microsatellite loci known to map to human chromosome 18 was screened for length polymorphisms in a multigenerational pedigree of baboons (Papio hamadryas). Eight of these loci were polymorphic in the baboon pedigrees, with observed heterozygosity values ranging from 0.16 to 0.88. All eight loci show strong evidence of linkage. The most likely map order among the microsatellite loci for Papio is completely compatible with the locus order found in the human genome, and sex differences in recombination rates are also similar in the two species. We conclude that the organization of the chromosomal region defined by these loci is largely conserved between baboons and humans.

DOI10.1159/000134484
Alternate JournalCytogenet. Cell Genet.
PubMed ID9067425
Grant ListHL28972 / HL / NHLBI NIH HHS / United States