Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants.

TitleConsistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants.
Publication TypeJournal Article
Year of Publication2006
AuthorsKlos, KLE, Sing, CF, Boerwinkle, E, Hamon, SC, Rea, TJ, Clark, A, Fornage, M, Hixson, JE
JournalArterioscler Thromb Vasc Biol
Volume26
Issue8
Pagination1828-36
Date Published2006 Aug
ISSN1524-4636
KeywordsAdult, African Continental Ancestry Group, Apolipoproteins, Apolipoproteins A, Apolipoproteins C, Apolipoproteins E, ATP Binding Cassette Transporter 1, ATP-Binding Cassette Transporters, Biological Transport, Active, Carrier Proteins, Cholesterol, Cholesterol Ester Transfer Proteins, Coronary Artery Disease, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genotype, Glycoproteins, Haplotypes, Humans, Lipids, Male, Polymorphism, Single Nucleotide
Abstract

OBJECTIVE: To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels.METHODS AND RESULTS: An average of 5 single nucleotide polymorphisms (SNPs) were genotyped within each of 45 genomic regions (54 genes) in blacks (1131 females and 812 males) and whites (1102 females and 954 males) from the Coronary Artery Risk Development in Young Adults (CARDIA) study. SNPs and gene-based 3-SNP haplotypes were evaluated for their ability to predict variation in plasma apolipoproteins (apo) A-I and apoB, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides (TG). We identified 14 SNPs in 6 candidate gene regions that explained statistically significant variation in the same trait in both genders of at least one race and with evidence of consistent genotype mean trend across gender within race. Haplotype analyses identified 9 candidate gene regions that explained statistically significant variation in one or both races.CONCLUSIONS: Four gene regions, ABCA1, APOA1/C3/A4/A5, APOE/C1/C4/C2, and CETP, explained plasma lipoprotein variation most consistently across strata. Other gene regions that influence plasma lipid and apolipoprotein levels within race include CYP7A1, LPL, PPARA, SOAT1, and SREBF2.

DOI10.1161/01.ATV.0000231523.19199.45
Alternate JournalArterioscler. Thromb. Vasc. Biol.
PubMed ID16763159
Grant ListGM065509 / GM / NIGMS NIH HHS / United States
HL072810 / HL / NHLBI NIH HHS / United States
HL072904 / HL / NHLBI NIH HHS / United States
HL072905 / HL / NHLBI NIH HHS / United States