Cortical sulcal areas in baboons (Papio hamadryas spp.) with generalized interictal epileptic discharges on scalp EEG.

TitleCortical sulcal areas in baboons (Papio hamadryas spp.) with generalized interictal epileptic discharges on scalp EEG.
Publication TypeJournal Article
Year of Publication2011
AuthorsSzabó, CA, Kochunov, P, Knape, KD, McCoy, KJM, Leland, MM, Lancaster, JL, Fox, PT, Williams, JT, Rogers, J
JournalEpilepsy Res
Volume93
Issue2-3
Pagination91-5
Date Published2011 Feb
ISSN1872-6844
KeywordsAnimals, Brain, Cerebral Cortex, Data Interpretation, Statistical, Electroencephalography, Epilepsy, Female, Functional Laterality, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Papio, Parietal Lobe, Seizures
Abstract

Brain MRI studies in people with idiopathic generalized epilepsies demonstrate regional morphometric differences, though variable in magnitude and location. As the baboon provides an excellent electroclinical and neuroimaging model for photosensitive generalized epilepsy in humans, this study evaluated MRI volumetric and morphometric differences between baboons with interictal epileptic discharges (IEDs) on scalp EEG and baboons with normal EEG studies. Seventy-seven baboons underwent high-resolution brain MRI and scalp EEG studies. The scans were acquired using an 8-channel primate head coil (Siemens TRIO 3T scanner, Erlangen, Germany). After spatial normalization, sulcal measurements were obtained by object-based-morphology methods. One-hour scalp EEG studies were performed in animals sedated with ketamine. Thirty-eight (22F/16M) baboons had normal EEGs (IED-), while 39 (22F/17M) had generalized IEDs (IED+). The two groups were compared for age, total brain volume, and sulcal areas (Hotelling's Trace) as well as between-subjects comparison of 11 individual sulcal areas (averaged between left and right hemispheres). There were no differences between IED- and IED+ groups with respect to age or total brain (gray or white matter) volume, and multivariate tests demonstrated a marginally significant decrease of sulcal areas in IED+ baboons (p=0.075). Tests of between-subjects effects showed statistically significant decreases in the intraparietal (p=0.002), central (p=0.03) and cingulate sulci (p=0.02), and marginal decreases involving the lunate (p=0.07) and superior temporal sulci (p=0.08). Differences in sulcal areas in IED+ baboons may reflect global developmental abnormalities, while decreases of areas of specific sulci reflect anatomical markers for potential generators or cortical nodes of the networks underlying spontaneous seizures and photosensitivity in the baboon.

DOI10.1016/j.eplepsyres.2010.10.016
Alternate JournalEpilepsy Res.
PubMed ID21256716
PubMed Central IDPMC3163477
Grant ListR01 NS047755 / NS / NINDS NIH HHS / United States
R21 NS065431-01 / NS / NINDS NIH HHS / United States
K01 EB006395-04 / EB / NIBIB NIH HHS / United States
K01 EB006395 / EB / NIBIB NIH HHS / United States
R21 NS065431 / NS / NINDS NIH HHS / United States
R01 NS047755-01 / NS / NINDS NIH HHS / United States
K01 EB006395-01A1 / EB / NIBIB NIH HHS / United States
K01 EB006395-02 / EB / NIBIB NIH HHS / United States
P51 OD011133 / OD / NIH HHS / United States
R21 NS065431-01A1 / NS / NINDS NIH HHS / United States
K01 EB006395-03 / EB / NIBIB NIH HHS / United States
P51 RR013986 / RR / NCRR NIH HHS / United States