Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.

TitleDiscovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Publication TypeJournal Article
Year of Publication2020
AuthorsSurendran, P, Feofanova, EV, Lahrouchi, N, Ntalla, I, Karthikeyan, S, Cook, J, Chen, L, Mifsud, B, Yao, C, Kraja, AT, Cartwright, JH, Hellwege, JN, Giri, A, Tragante, V, Thorleifsson, G, Liu, DJ, Prins, BP, Stewart, ID, Cabrera, CP, Eales, JM, Akbarov, A, Auer, PL, Bielak, LF, Bis, JC, Braithwaite, VS, Brody, JA, E Daw, W, Warren, HR, Drenos, F, Nielsen, SFallgaard, Faul, JD, Fauman, EB, Fava, C, Ferreira, T, Foley, CN, Franceschini, N, Gao, H, Giannakopoulou, O, Giulianini, F, Gudbjartsson, DF, Guo, X, Harris, SE, Havulinna, AS, Helgadottir, A, Huffman, JE, Hwang, S-J, Kanoni, S, Kontto, J, Larson, MG, Li-Gao, R, Lindström, J, Lotta, LA, Lu, Y, Luan, J'an, Mahajan, A, Malerba, G, Masca, NGD, Mei, H, Menni, C, Mook-Kanamori, DO, Mosen-Ansorena, D, Müller-Nurasyid, M, Paré, G, Paul, DS, Perola, M, Poveda, A, Rauramaa, R, Richard, M, Richardson, TG, Sepúlveda, N, Sim, X, Smith, AV, Smith, JA, Staley, JR, Stanáková, A, Sulem, P, Thériault, S, Thorsteinsdottir, U, Trompet, S, Varga, TV, Edwards, DRVelez, Veronesi, G, Weiss, S, Willems, SM, Yao, J, Young, R, Yu, B, Zhang, W, Zhao, J-H, Zhao, W, Zhao, W, Evangelou, E, Aeschbacher, S, Asllanaj, E, Blankenberg, S, Bonnycastle, LL, Bork-Jensen, J, Brandslund, I, Braund, PS, Burgess, S, Cho, K, Christensen, C, Connell, J, de Mutsert, R, Dominiczak, AF, Dörr, M, Eiriksdottir, G, Farmaki, A-E, J Gaziano, M, Grarup, N, Grove, ML, Hallmans, G, Hansen, T, Have, CT, Heiss, G, Jørgensen, ME, Jousilahti, P, Kajantie, E, Kamat, M, Käräjämäki, A, Karpe, F, Koistinen, HA, Kovesdy, CP, Kuulasmaa, K, Laatikainen, T, Lannfelt, L, Lee, I-T, Lee, W-J, Linneberg, A, Martin, LW, Moitry, M, Nadkarni, G, Neville, MJ, Palmer, CNA, Papanicolaou, GJ, Pedersen, O, Peters, J, Poulter, N, Rasheed, A, Rasmussen, KL, N Rayner, W, Mägi, R, Renstrom, F, Rettig, R, Rossouw, J, Schreiner, PJ, Sever, PS, Sigurdsson, EL, Skaaby, T, Sun, YV, Sundström, J, Thorgeirsson, G, Esko, T, Trabetti, E, Tsao, PS, Tuomi, T, Turner, ST, Tzoulaki, I, Vaartjes, I, Vergnaud, A-C, Willer, CJ, Wilson, PWF, Witte, DR, Yonova-Doing, E, Zhang, H, Aliya, N, Almgren, P, Amouyel, P, Asselbergs, FW, Barnes, MR, Blakemore, AI, Boehnke, M, Bots, ML, Bottinger, EP, Buring, JE, Chambers, JC, Chen, Y-DIda, Chowdhury, iv, R, Conen, D, Correa, A, Smith, GDavey, de Boer, RA, Deary, IJ, Dedoussis, G, Deloukas, P, Di Angelantonio, E, Elliott, P, Felix, SB, Ferrieres, J, Ford, I, Fornage, M, Franks, PW, Franks, S, Frossard, P, Gambaro, G, Gaunt, TR, Groop, L, Gudnason, V, Harris, TB, Hayward, C, Hennig, BJ, Herzig, K-H, Ingelsson, E, Tuomilehto, J, Jarvelin, M-R, J Jukema, W, Kardia, SLR, Kee, F, Kooner, JS, Kooperberg, C, Launer, LJ, Lind, L, Loos, RJF, Majumder, AAl Shafi, Laakso, M, McCarthy, MI, Melander, O, Mohlke, KL, Murray, AD, Nordestgaard, BGrønne, Orho-Melander, M, Packard, CJ, Padmanabhan, S, Palmas, W, Polasek, O, Porteous, DJ, Prentice, AM, Province, MA, Relton, CL, Rice, K, Ridker, PM, Rolandsson, O, Rosendaal, FR, Rotter, JI, Rudan, I, Salomaa, V, Samani, NJ, Sattar, N, Sheu, WH-H, Smith, BH, Soranzo, N, Spector, TD, Starr, JM, Sebert, S, Taylor, KD, Lakka, TA, Timpson, NJ, Tobin, MD, van der Harst, P, van der Meer, P, Ramachandran, VS, Verweij, N, Virtamo, J, Völker, U, Weir, DR, Zeggini, E, Charchar, FJ, Wareham, NJ, Langenberg, C, Tomaszewski, M, Butterworth, AS, Caulfield, MJ, Danesh, J, Edwards, TL, Holm, H, Hung, AM, Lindgren, CM, Liu, C, Manning, AK, Morris, AP, Morrison, AC, O'Donnell, CJ, Psaty, BM, Saleheen, D, Stefansson, K, Boerwinkle, E, Chasman, DI, Levy, D, Newton-Cheh, C, Munroe, PB, Howson, JMM
Corporate AuthorsLifeLines Cohort Study, EPIC-CVD, EPIC-InterAct, Understanding Society Scientific Group, Million Veteran Program
JournalNat Genet
Volume52
Issue12
Pagination1314-1332
Date Published2020 12
ISSN1546-1718
KeywordsBlood Pressure, GATA5 Transcription Factor, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Hypertension, Mutation, Phospholipase C beta, Polymorphism, Single Nucleotide
Abstract

Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P 

DOI10.1038/s41588-020-00713-x
Alternate JournalNat Genet
PubMed ID33230300
PubMed Central IDPMC7610439
Grant ListR21 HL140385 / HL / NHLBI NIH HHS / United States
268834 / ERC_ / European Research Council / International
212259 / WT_ / Wellcome Trust / United Kingdom
MC_UU_00006/1 / MRC_ / Medical Research Council / United Kingdom
MC_UU_00026/3 / MRC_ / Medical Research Council / United Kingdom
G0800270 / MRC_ / Medical Research Council / United Kingdom
MC_UU_00011/5 / MRC_ / Medical Research Council / United Kingdom
MC_UU_12013/2 / MRC_ / Medical Research Council / United Kingdom
R01 DK093757 / DK / NIDDK NIH HHS / United States
SP/09/002 / BHF_ / British Heart Foundation / United Kingdom
MR/L003120/1 / MRC_ / Medical Research Council / United Kingdom
U01 HG007417 / HG / NHGRI NIH HHS / United States
P50 HD028138 / HD / NICHD NIH HHS / United States
098381 / WT_ / Wellcome Trust / United Kingdom
G9521010 / MRC_ / Medical Research Council / United Kingdom
MR/S003746/1 / MRC_ / Medical Research Council / United Kingdom
MR/S004068/1 / MRC_ / Medical Research Council / United Kingdom
RG/13/13/30194 / BHF_ / British Heart Foundation / United Kingdom
R01 HL120393 / HL / NHLBI NIH HHS / United States
MC_PC_U127592696 / MRC_ / Medical Research Council / United Kingdom
MR/N003284/1 / MRC_ / Medical Research Council / United Kingdom
203141 / WT_ / Wellcome Trust / United Kingdom
U01 HL120393 / HL / NHLBI NIH HHS / United States
T32 CA160056 / CA / NCI NIH HHS / United States
R01 DK117445 / DK / NIDDK NIH HHS / United States
R01 DK072193 / DK / NIDDK NIH HHS / United States
MC_UU_00011/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK110113 / DK / NIDDK NIH HHS / United States
RG/18/13/33946 / BHF_ / British Heart Foundation / United Kingdom
MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom
R01 DK107786 / DK / NIDDK NIH HHS / United States
MC_UU_00011/4 / MRC_ / Medical Research Council / United Kingdom
NF-SI-0617-10090 / DH_ / Department of Health / United Kingdom
106130 / WT_ / Wellcome Trust / United Kingdom
RG/14/5/30893 / BHF_ / British Heart Foundation / United Kingdom
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
MC_UU_00002/7 / MRC_ / Medical Research Council / United Kingdom
R01 DK062370 / DK / NIDDK NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
MC_PC_MR/R020183/1 / MRC_ / Medical Research Council / United Kingdom
MC_U106179471 / MRC_ / Medical Research Council / United Kingdom
PG/17/35/33001 / BHF_ / British Heart Foundation / United Kingdom
R01 DK101855 / DK / NIDDK NIH HHS / United States
PG/19/16/34270 / BHF_ / British Heart Foundation / United Kingdom
090532 / WT_ / Wellcome Trust / United Kingdom
K12 HD043483 / HD / NICHD NIH HHS / United States
MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom
R21 HL123677 / HL / NHLBI NIH HHS / United States
RE/18/6/34217 / BHF_ / British Heart Foundation / United Kingdom
R01 MD012765 / MD / NIMHD NIH HHS / United States
/ WT_ / Wellcome Trust / United Kingdom