Title | Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Surendran, P, Feofanova, EV, Lahrouchi, N, Ntalla, I, Karthikeyan, S, Cook, J, Chen, L, Mifsud, B, Yao, C, Kraja, AT, Cartwright, JH, Hellwege, JN, Giri, A, Tragante, V, Thorleifsson, G, Liu, DJ, Prins, BP, Stewart, ID, Cabrera, CP, Eales, JM, Akbarov, A, Auer, PL, Bielak, LF, Bis, JC, Braithwaite, VS, Brody, JA, E Daw, W, Warren, HR, Drenos, F, Nielsen, SFallgaard, Faul, JD, Fauman, EB, Fava, C, Ferreira, T, Foley, CN, Franceschini, N, Gao, H, Giannakopoulou, O, Giulianini, F, Gudbjartsson, DF, Guo, X, Harris, SE, Havulinna, AS, Helgadottir, A, Huffman, JE, Hwang, S-J, Kanoni, S, Kontto, J, Larson, MG, Li-Gao, R, Lindström, J, Lotta, LA, Lu, Y, Luan, J'an, Mahajan, A, Malerba, G, Masca, NGD, Mei, H, Menni, C, Mook-Kanamori, DO, Mosen-Ansorena, D, Müller-Nurasyid, M, Paré, G, Paul, DS, Perola, M, Poveda, A, Rauramaa, R, Richard, M, Richardson, TG, Sepúlveda, N, Sim, X, Smith, AV, Smith, JA, Staley, JR, Stanáková, A, Sulem, P, Thériault, S, Thorsteinsdottir, U, Trompet, S, Varga, TV, Edwards, DRVelez, Veronesi, G, Weiss, S, Willems, SM, Yao, J, Young, R, Yu, B, Zhang, W, Zhao, J-H, Zhao, W, Zhao, W, Evangelou, E, Aeschbacher, S, Asllanaj, E, Blankenberg, S, Bonnycastle, LL, Bork-Jensen, J, Brandslund, I, Braund, PS, Burgess, S, Cho, K, Christensen, C, Connell, J, de Mutsert, R, Dominiczak, AF, Dörr, M, Eiriksdottir, G, Farmaki, A-E, J Gaziano, M, Grarup, N, Grove, ML, Hallmans, G, Hansen, T, Have, CT, Heiss, G, Jørgensen, ME, Jousilahti, P, Kajantie, E, Kamat, M, Käräjämäki, A, Karpe, F, Koistinen, HA, Kovesdy, CP, Kuulasmaa, K, Laatikainen, T, Lannfelt, L, Lee, I-T, Lee, W-J, Linneberg, A, Martin, LW, Moitry, M, Nadkarni, G, Neville, MJ, Palmer, CNA, Papanicolaou, GJ, Pedersen, O, Peters, J, Poulter, N, Rasheed, A, Rasmussen, KL, N Rayner, W, Mägi, R, Renstrom, F, Rettig, R, Rossouw, J, Schreiner, PJ, Sever, PS, Sigurdsson, EL, Skaaby, T, Sun, YV, Sundström, J, Thorgeirsson, G, Esko, T, Trabetti, E, Tsao, PS, Tuomi, T, Turner, ST, Tzoulaki, I, Vaartjes, I, Vergnaud, A-C, Willer, CJ, Wilson, PWF, Witte, DR, Yonova-Doing, E, Zhang, H, Aliya, N, Almgren, P, Amouyel, P, Asselbergs, FW, Barnes, MR, Blakemore, AI, Boehnke, M, Bots, ML, Bottinger, EP, Buring, JE, Chambers, JC, Chen, Y-DIda, Chowdhury, iv, R, Conen, D, Correa, A, Smith, GDavey, de Boer, RA, Deary, IJ, Dedoussis, G, Deloukas, P, Di Angelantonio, E, Elliott, P, Felix, SB, Ferrieres, J, Ford, I, Fornage, M, Franks, PW, Franks, S, Frossard, P, Gambaro, G, Gaunt, TR, Groop, L, Gudnason, V, Harris, TB, Hayward, C, Hennig, BJ, Herzig, K-H, Ingelsson, E, Tuomilehto, J, Jarvelin, M-R, J Jukema, W, Kardia, SLR, Kee, F, Kooner, JS, Kooperberg, C, Launer, LJ, Lind, L, Loos, RJF, Majumder, AAl Shafi, Laakso, M, McCarthy, MI, Melander, O, Mohlke, KL, Murray, AD, Nordestgaard, BGrønne, Orho-Melander, M, Packard, CJ, Padmanabhan, S, Palmas, W, Polasek, O, Porteous, DJ, Prentice, AM, Province, MA, Relton, CL, Rice, K, Ridker, PM, Rolandsson, O, Rosendaal, FR, Rotter, JI, Rudan, I, Salomaa, V, Samani, NJ, Sattar, N, Sheu, WH-H, Smith, BH, Soranzo, N, Spector, TD, Starr, JM, Sebert, S, Taylor, KD, Lakka, TA, Timpson, NJ, Tobin, MD, van der Harst, P, van der Meer, P, Ramachandran, VS, Verweij, N, Virtamo, J, Völker, U, Weir, DR, Zeggini, E, Charchar, FJ, Wareham, NJ, Langenberg, C, Tomaszewski, M, Butterworth, AS, Caulfield, MJ, Danesh, J, Edwards, TL, Holm, H, Hung, AM, Lindgren, CM, Liu, C, Manning, AK, Morris, AP, Morrison, AC, O'Donnell, CJ, Psaty, BM, Saleheen, D, Stefansson, K, Boerwinkle, E, Chasman, DI, Levy, D, Newton-Cheh, C, Munroe, PB, Howson, JMM |
Corporate Authors | LifeLines Cohort Study, EPIC-CVD, EPIC-InterAct, Understanding Society Scientific Group, Million Veteran Program |
Journal | Nat Genet |
Volume | 52 |
Issue | 12 |
Pagination | 1314-1332 |
Date Published | 2020 Dec |
ISSN | 1546-1718 |
Keywords | Blood Pressure, GATA5 Transcription Factor, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Hypertension, Mutation, Phospholipase C beta, Polymorphism, Single Nucleotide |
Abstract | Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P |
DOI | 10.1038/s41588-020-00713-x |
Alternate Journal | Nat Genet |
PubMed ID | 33230300 |
PubMed Central ID | PMC7610439 |
Grant List | MC_UU_12013/2 / MRC_ / Medical Research Council / United Kingdom R21 HL140385 / HL / NHLBI NIH HHS / United States MR/L01341X/1 / MRC_ / Medical Research Council / United Kingdom 268834 / ERC_ / European Research Council / International 204623/Z/16/Z / WT_ / Wellcome Trust / United Kingdom 202802/Z/16/Z / WT_ / Wellcome Trust / United Kingdom MC_UU_00011/5 / MRC_ / Medical Research Council / United Kingdom R01 DK093757 / DK / NIDDK NIH HHS / United States MR/L003120/1 / MRC_ / Medical Research Council / United Kingdom U01 HG007417 / HG / NHGRI NIH HHS / United States P50 HD028138 / HD / NICHD NIH HHS / United States 098381 / WT_ / Wellcome Trust / United Kingdom MC_PC_MR/R020183/1 / MRC_ / Medical Research Council / United Kingdom MR/S003746/1 / MRC_ / Medical Research Council / United Kingdom MC_UU_00006/1 / MRC_ / Medical Research Council / United Kingdom R01 HL120393 / HL / NHLBI NIH HHS / United States MC_PC_U127592696 / MRC_ / Medical Research Council / United Kingdom MC_UU_00026/3 / MRC_ / Medical Research Council / United Kingdom 203141 / WT_ / Wellcome Trust / United Kingdom RG/13/13/30194 / BHF_ / British Heart Foundation / United Kingdom MR/S004068/1 / MRC_ / Medical Research Council / United Kingdom MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom U01 HL120393 / HL / NHLBI NIH HHS / United States T32 CA160056 / CA / NCI NIH HHS / United States R01 DK117445 / DK / NIDDK NIH HHS / United States R01 DK072193 / DK / NIDDK NIH HHS / United States MC_UU_00011/1 / MRC_ / Medical Research Council / United Kingdom R01 DK110113 / DK / NIDDK NIH HHS / United States RG/18/13/33946 / BHF_ / British Heart Foundation / United Kingdom SP/09/002 / BHF_ / British Heart Foundation / United Kingdom R01 DK107786 / DK / NIDDK NIH HHS / United States MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom MR/N003284/1 / MRC_ / Medical Research Council / United Kingdom MC_UU_00011/4 / MRC_ / Medical Research Council / United Kingdom NF-SI-0617-10090 / DH_ / Department of Health / United Kingdom 106130 / WT_ / Wellcome Trust / United Kingdom RG/14/5/30893 / BHF_ / British Heart Foundation / United Kingdom R01 DK062370 / DK / NIDDK NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States MR/S004068/2 / MRC_ / Medical Research Council / United Kingdom MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom PG/17/35/33001 / BHF_ / British Heart Foundation / United Kingdom R01 DK101855 / DK / NIDDK NIH HHS / United States G0401527 / MRC_ / Medical Research Council / United Kingdom PG/19/16/34270 / BHF_ / British Heart Foundation / United Kingdom G9521010 / MRC_ / Medical Research Council / United Kingdom G1000143 / MRC_ / Medical Research Council / United Kingdom MC_UU_00002/7 / MRC_ / Medical Research Council / United Kingdom 212259 / WT_ / Wellcome Trust / United Kingdom U01 DK062370 / DK / NIDDK NIH HHS / United States 090532 / WT_ / Wellcome Trust / United Kingdom K12 HD043483 / HD / NICHD NIH HHS / United States R21 HL123677 / HL / NHLBI NIH HHS / United States 14136 / CRUK_ / Cancer Research UK / United Kingdom RE/18/6/34217 / BHF_ / British Heart Foundation / United Kingdom R01 MD012765 / MD / NIMHD NIH HHS / United States / WT_ / Wellcome Trust / United Kingdom MC_U106179471 / MRC_ / Medical Research Council / United Kingdom G0800270 / MRC_ / Medical Research Council / United Kingdom |
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
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