DNA Methylation-Derived Immune Cell Proportions and Cancer Risk in Black Participants.

TitleDNA Methylation-Derived Immune Cell Proportions and Cancer Risk in Black Participants.
Publication TypeJournal Article
Year of Publication2024
AuthorsSemancik, CS, Zhao, N, Koestler, DC, Boerwinkle, E, Bressler, J, Buchsbaum, RJ, Kelsey, KT, Platz, EA, Michaud, DS
JournalCancer Res Commun
Volume4
Issue10
Pagination2714-2723
Date Published2024 Oct 01
ISSN2767-9764
KeywordsAdult, Aged, B-Lymphocytes, Black or African American, DNA Methylation, Female, Humans, Lung Neoplasms, Male, Middle Aged, Neoplasms, Risk Factors, T-Lymphocytes, Regulatory
Abstract

This study describes associations between immune cell types and cancer risk in a Black population; elevated regulatory T-cell proportions that were associated with increased overall cancer and lung cancer risk, and elevated memory B-cell proportions that were associated with increased prostate and all cancer risk.
DOI10.1158/2767-9764.CRC-24-0257
Alternate JournalCancer Res Commun
PubMed ID39324671
PubMed Central IDPMC11484294
Grant ListRC2 HL102419 / HL / NHLBI NIH HHS / United States
75N92022D00002 / HL / NHLBI NIH HHS / United States
R01 NS087541 / NS / NINDS NIH HHS / United States
75N92022D00004 / HL / NHLBI NIH HHS / United States
75N92022D00003 / HL / NHLBI NIH HHS / United States
75N92022D00005 / HL / NHLBI NIH HHS / United States
U01 CA164975 / CA / NCI NIH HHS / United States
75N92022D00001 / HL / NHLBI NIH HHS / United States

Similar Publications

Semancik CS, Zhao N, Koestler DC, Boerwinkle E, Bressler J, Buchsbaum RJ, et al.. DNA Methylation-Derived Immune Cell Proportions and Cancer Risk in Black Participants. Cancer Res Commun. 2024;4(10):2714-2723.
Dwarshuis N, Tonner P, Olson ND, Sedlazeck FJ, Wagner J, Zook JM. StratoMod: predicting sequencing and variant calling errors with interpretable machine learning. Commun Biol. 2024;7(1):1316.
Behera S, Belyeu JR, Chen X, Paulin LF, Nguyen NQuynh H, Newman E, et al.. Identification of allele-specific KIV-2 repeats and impact on Lp(a) measurements for cardiovascular disease risk. BMC Med Genomics. 2024;17(1):255.