A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal.

TitleA dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal.
Publication TypeJournal Article
Year of Publication1994
AuthorsBardoni, B, Zanaria, E, Guioli, S, Floridia, G, Worley, KC, Tonini, G, Ferrante, E, Chiumello, G, McCabe, ER, Fraccaro, M
JournalNat Genet
Volume7
Issue4
Pagination497-501
Date Published1994 Aug
ISSN1061-4036
KeywordsChromosome Mapping, Dosage Compensation, Genetic, Female, Gene Deletion, Genetic Markers, Humans, Male, Multigene Family, Ovary, Phenotype, Sex Differentiation, Testis, X Chromosome
Abstract

Male to female sex reversal has been observed in individuals with duplications of the short arm of the X chromosome. Here we demonstrate that sex reversal results from the presence of two active copies of an Xp locus rather than from its rearrangement and that alterations at this locus constitute one of the causes of sex reversal in individuals with a normal 46,XY karyotype. We have named this locus DSS (Dosage Sensitive Sex reversal) and localized it to a 160 kilobase region of chromosome Xp21, adjacent to the adrenal hypoplasia congenita locus. The identification of male individuals deleted for DSS suggests that this locus is not required for testis differentiation. We propose that DSS has a role in ovarian development and/or functions as a link between ovary and testis formation.

DOI10.1038/ng0894-497
Alternate JournalNat. Genet.
PubMed ID7951319
Grant ListB.05 / / Telethon / Italy