The Drosophila melanogaster Genetic Reference Panel.

TitleThe Drosophila melanogaster Genetic Reference Panel.
Publication TypeJournal Article
Year of Publication2012
AuthorsMackay, TFC, Richards, S, Stone, EA, Barbadilla, A, Ayroles, JF, Zhu, D, Casillas, S, Han, Y, Magwire, MM, Cridland, JM, Richardson, MF, Anholt, RRH, Barrón, M, Bess, C, Blankenburg, KPetra, Carbone, MAnna, Castellano, D, Chaboub, L, Duncan, L, Harris, Z, Javaid, M, Jayaseelan, JChristina, Jhangiani, SN, Jordan, KW, Lara, F, Lawrence, F, Lee, SL, Librado, P, Linheiro, RS, Lyman, RF, Mackey, AJ, Munidasa, M, Muzny, DM, Nazareth, L, Newsham, I, Perales, L, Pu, L-L, Qu, C, Ràmia, M, Reid, JG, Rollmann, SM, Rozas, J, Saada, N, Turlapati, L, Worley, KC, Wu, Y-Q, Yamamoto, A, Zhu, Y, Bergman, CM, Thornton, KR, Mittelman, D, Gibbs, RA
JournalNature
Volume482
Issue7384
Pagination173-8
Date Published2012 Feb 9
ISSN1476-4687
KeywordsAlleles, Animals, Centromere, Chromosomes, Insect, Drosophila melanogaster, Genome-Wide Association Study, Genomics, Genotype, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Selection, Genetic, Starvation, Telomere, X Chromosome
Abstract

A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics.

DOI10.1038/nature10811
Alternate JournalNature
PubMed ID22318601
PubMed Central IDPMC3683990
Grant ListGM 45146 / GM / NIGMS NIH HHS / United States
R01 GM 059469 / GM / NIGMS NIH HHS / United States
R01 GM 085183 / GM / NIGMS NIH HHS / United States
R01 GM045146 / GM / NIGMS NIH HHS / United States
U54 HG003273 / HG / NHGRI NIH HHS / United States
U54 HG003273 / HG / NHGRI NIH HHS / United States