Title | The Ensembl gene annotation system. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Aken, BL, Ayling, S, Barrell, D, Clarke, L, Curwen, V, Fairley, S, Banet, JFernandez, Billis, K, Girón, CGarcía, Hourlier, T, Howe, K, Kähäri, A, Kokocinski, F, Martin, FJ, Murphy, DN, Nag, R, Ruffier, M, Schuster, M, Y Tang, A, Vogel, J-H, White, S, Zadissa, A, Flicek, P, Searle, SMJ |
Journal | Database (Oxford) |
Volume | 2016 |
Date Published | 2016 |
ISSN | 1758-0463 |
Keywords | Animals, Databases, Nucleic Acid, Databases, Protein, Humans, Internet, Mice, Molecular Sequence Annotation |
Abstract | The Ensembl gene annotation system has been used to annotate over 70 different vertebrate species across a wide range of genome projects. Furthermore, it generates the automatic alignment-based annotation for the human and mouse GENCODE gene sets. The system is based on the alignment of biological sequences, including cDNAs, proteins and RNA-seq reads, to the target genome in order to construct candidate transcript models. Careful assessment and filtering of these candidate transcripts ultimately leads to the final gene set, which is made available on the Ensembl website. Here, we describe the annotation process in detail.Database URL: http://www.ensembl.org/index.html. |
DOI | 10.1093/database/baw093 |
Alternate Journal | Database (Oxford) |
PubMed ID | 27337980 |
PubMed Central ID | PMC4919035 |
Grant List | WT095908 / WT_ / Wellcome Trust / United Kingdom BB/I025506/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom BB/K009524/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom WT098051 / WT_ / Wellcome Trust / United Kingdom BB/I025360/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom U54 HG004555 / HG / NHGRI NIH HHS / United States BB/I025360/2 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom BB/M011615/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom BB/E011640/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom U41 HG007234 / HG / NHGRI NIH HHS / United States R01 HD074078 / HD / NICHD NIH HHS / United States BBS/B/13446 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom BB/M018458/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom BBS/B/13470 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom BB/M011461/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom |
The Ensembl gene annotation system.
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