An Epigenome-Wide Association Study (EWAS) of Obesity-Related Traits.

TitleAn Epigenome-Wide Association Study (EWAS) of Obesity-Related Traits.
Publication TypeJournal Article
Year of Publication2018
AuthorsDhana, K, Braun, KVE, Nano, J, Voortman, T, Demerath, EW, Guan, W, Fornage, M, van Meurs, JBJ, Uitterlinden, AG, Hofman, A, Franco, OH, Dehghan, A
JournalAm J Epidemiol
Date Published2018 May 14
ISSN1476-6256
Abstract

We conducted an epigenome-wide association study on obesity-related traits. We used data from two prospective, population-based cohort studies: the Rotterdam Study (RS) (2006-2013) and the Atherosclerosis Risk in Communities (ARIC) Study (1990-1992). We used RS (n = 1,454) as the discovery panel and ARIC (n = 2,097) as replication panel. Linear mixed-effect models were used to assess the cross-sectional association between genome-wide DNA methylation in leukocytes with body mass index (BMI) and waist circumference (WC) adjusting for sex, age, smoking, leukocyte proportions, array number and position on array. The two latter were modelled as random effects. Fourteen CpGs were associated with BMI and 26 CpGs with WC in RS after Bonferroni-correction (P 

DOI10.1093/aje/kwy025
Alternate JournalAm. J. Epidemiol.
PubMed ID29762635