Epigenome-wide association study of mitochondrial genome copy number.

TitleEpigenome-wide association study of mitochondrial genome copy number.
Publication TypeJournal Article
Year of Publication2021
AuthorsWang, P, Castellani, CA, Yao, J, Huan, T, Bielak, LF, Zhao, W, Haessler, J, Roby, J, Sun, X, Guo, X, Longchamps, RJ, Manson, JAE, Grove, ML, Bressler, J, Taylor, KD, Lappalainen, T, Kasela, S, Van Den Berg, DJ, Hou, L, Reiner, A, Liu, Y, Boerwinkle, E, Smith, JA, Peyser, PA, Fornage, M, Rich, SS, Rotter, JI, Kooperberg, C, Arking, DE, Levy, D, Liu, C
Corporate AuthorsNHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
JournalHum Mol Genet
Date Published2021 Aug 20
ISSN1460-2083
Abstract

We conducted cohort- and race-specific epigenome-wide association analyses of mtDNA copy number (mtDNA CN) measured in whole blood from participants of African and European origins in five cohorts (n = 6182, mean age 57-67 years, 65% women). In the meta-analysis of all the participants, we discovered 21 mtDNA CN-associated CpG sites (p 

DOI10.1093/hmg/ddab240
Alternate JournalHum Mol Genet
PubMed ID34415308
Grant ListR01 HL133221 / HL / NHLBI NIH HHS / United States