Epigenome-wide association study of mitochondrial genome copy number.

TitleEpigenome-wide association study of mitochondrial genome copy number.
Publication TypeJournal Article
Year of Publication2021
AuthorsWang, P, Castellani, CA, Yao, J, Huan, T, Bielak, LF, Zhao, W, Haessler, J, Joehanes, R, Sun, X, Guo, X, Longchamps, RJ, Manson, JAE, Grove, ML, Bressler, J, Taylor, KD, Lappalainen, T, Kasela, S, Van Den Berg, DJ, Hou, L, Reiner, A, Liu, Y, Boerwinkle, E, Smith, JA, Peyser, PA, Fornage, M, Rich, SS, Rotter, JI, Kooperberg, C, Arking, DE, Levy, D, Liu, C
Corporate AuthorsNHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
JournalHum Mol Genet
Volume31
Issue2
Pagination309-319
Date Published2021 12 27
ISSN1460-2083
KeywordsAged, DNA Copy Number Variations, DNA Methylation, DNA, Mitochondrial, Epigenome, Female, Genome, Mitochondrial, Humans, Male, Middle Aged
Abstract

We conducted cohort- and race-specific epigenome-wide association analyses of mitochondrial deoxyribonucleic acid (mtDNA) copy number (mtDNA CN) measured in whole blood from participants of African and European origins in five cohorts (n = 6182, mean age = 57-67 years, 65% women). In the meta-analysis of all the participants, we discovered 21 mtDNA CN-associated DNA methylation sites (CpG) (P 

DOI10.1093/hmg/ddab240
Alternate JournalHum Mol Genet
PubMed ID34415308
PubMed Central IDPMC8742999
Grant ListR01 HL120393 / HL / NHLBI NIH HHS / United States
U01 DK062413 / DK / NIDDK NIH HHS / United States
U01 HL120393 / HL / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
HHSN268201800001C / HL / NHLBI NIH HHS / United States
R01 HL133221 / HL / NHLBI NIH HHS / United States
R01 HL144569 / HL / NHLBI NIH HHS / United States
R01 HL131573 / HL / NHLBI NIH HHS / United States
R01 HL117626 / HL / NHLBI NIH HHS / United States
R01 HL155569 / HL / NHLBI NIH HHS / United States