| Title | An Epigenome-Wide Association Study of Obesity-Related Traits. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Dhana, K, Braun, KVE, Nano, J, Voortman, T, Demerath, EW, Guan, W, Fornage, M, van Meurs, JBJ, Uitterlinden, AG, Hofman, A, Franco, OH, Dehghan, A |
| Journal | Am J Epidemiol |
| Volume | 187 |
| Issue | 8 |
| Pagination | 1662-1669 |
| Date Published | 2018 08 01 |
| ISSN | 1476-6256 |
| Keywords | Amino Acyl-tRNA Synthetases, Biomarkers, CpG Islands, DNA Methylation, Epigenomics, Female, Genome-Wide Association Study, Humans, Male, Middle Aged, Netherlands, Obesity, Phenotype, Prospective Studies, RNA-Binding Proteins, United States |
| Abstract | We conducted an epigenome-wide association study on obesity-related traits. We used data from 2 prospective, population-based cohort studies: the Rotterdam Study (RS) (2006-2013) and the Atherosclerosis Risk in Communities (ARIC) Study (1990-1992). We used the RS (n = 1,450) as the discovery panel and the ARIC Study (n = 2,097) as the replication panel. Linear mixed-effect models were used to assess the cross-sectional associations between genome-wide DNA methylation in leukocytes and body mass index (BMI) and waist circumference (WC), adjusting for sex, age, smoking, leukocyte proportions, array number, and position on array. The latter 2 variables were modeled as random effects. Fourteen 5'-C-phosphate-G-3' (CpG) sites were associated with BMI and 26 CpG sites with WC in the RS after Bonferroni correction (P |
| DOI | 10.1093/aje/kwy025 |
| Alternate Journal | Am J Epidemiol |
| PubMed ID | 29762635 |
| PubMed Central ID | PMC6070087 |