Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia.

TitleEvaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia.
Publication TypeJournal Article
Year of Publication2006
AuthorsBonnen, PE, Pe'er, I, Plenge, RM, Salit, J, Lowe, JK, Shapero, MH, Lifton, RP, Breslow, JL, Daly, MJ, Reich, DE, Jones, KW, Stoffel, M, Altshuler, D, Friedman, JM
JournalNat Genet
Volume38
Issue2
Pagination214-7
Date Published2006 Feb
ISSN1061-4036
KeywordsAlleles, Gene Frequency, Genetic Predisposition to Disease, Genetics, Medical, Genome, Human, Haplotypes, Humans, Linkage Disequilibrium, Micronesia, Polymorphism, Single Nucleotide
Abstract

Whole-genome association studies are predicted to be especially powerful in isolated populations owing to increased linkage disequilibrium (LD) and decreased allelic diversity, but this possibility has not been empirically tested. We compared genome-wide data on 113,240 SNPs typed on 30 trios from the Pacific island of Kosrae to the same markers typed in the 270 samples from the International HapMap Project. The extent of LD is longer and haplotype diversity is lower in Kosrae than in the HapMap populations. More than 98% of Kosraen haplotypes are present in HapMap populations, indicating that HapMap will be useful for genetic studies on Kosrae. The long-range LD around common alleles and limited diversity result in improved efficiency in genetic studies in this population and augments the power to detect association of 'hidden SNPs'.

DOI10.1038/ng1712
Alternate JournalNat. Genet.
PubMed ID16429162