Evolutionary and developmental implications of asymmetric brain folding in a large primate pedigree.

TitleEvolutionary and developmental implications of asymmetric brain folding in a large primate pedigree.
Publication TypeJournal Article
Year of Publication2016
AuthorsAtkinson, EG, Rogers, J, Cheverud, JM
JournalEvolution
Volume70
Issue3
Pagination707-15
Date Published2016 Mar
ISSN1558-5646
Abstract

Bilateral symmetry is a fundamental property of the vertebrate central nervous system. Local deviations from symmetry provide various types of information about the development, evolution, and function of elements within the CNS, especially the cerebral hemispheres. Here, we quantify the pattern and extent of asymmetry in cortical folding within the cerebrum of Papio baboons and assess the evolutionary and developmental implications of the findings. Analyses of directional asymmetry show a population-level trend in length measurements indicating that baboons are genetically predisposed to be asymmetrical, with the right side longer than the left in the anterior cerebrum while the left side is longer than the right posteriorly. We also find a corresponding bias to display a right frontal petalia (overgrowth of the anterior pole of the cerebral cortex on the right side). By quantifying fluctuating asymmetry, we assess canalization of brain features and the susceptibility of the baboon brain to developmental perturbations. We find that features are differentially canalized depending on their ontogenetic timing. We further deduce that development of the two hemispheres is to some degree independent. This independence has important implications for the evolution of cerebral hemispheres and their separate specialization. Asymmetry is a major feature of primate brains and is characteristic of both brain structure and function.

DOI10.1111/evo.12867
Alternate JournalEvolution
PubMed ID26813679
PubMed Central IDPMC4801758
Grant ListGM-102778 / GM / NIGMS NIH HHS / United States
K12 GM102778 / GM / NIGMS NIH HHS / United States
P51RR013986 / RR / NCRR NIH HHS / United States
P51 OD011133 / OD / NIH HHS / United States
P51 RR013986 / RR / NCRR NIH HHS / United States