| Title | An exome array study of the plasma metabolome. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Rhee, EP, Yang, Q, Yu, B, Liu, X, Cheng, S, Deik, A, Pierce, KA, Bullock, K, Ho, JE, Levy, D, Florez, JC, Kathiresan, S, Larson, MG, Vasan, RS, Clish, CB, Wang, TJ, Boerwinkle, E, O'Donnell, CJ, Gerszten, RE |
| Journal | Nat Commun |
| Volume | 7 |
| Pagination | 12360 |
| Date Published | 2016 Jul 25 |
| ISSN | 2041-1723 |
| Abstract | The study of rare variants may enhance our understanding of the genetic determinants of the metabolome. Here, we analyze the association between 217 plasma metabolites and exome variants on the Illumina HumanExome Beadchip in 2,076 participants in the Framingham Heart Study, with replication in 1,528 participants of the Atherosclerosis Risk in Communities Study. We identify an association between GMPS and xanthosine using single variant analysis and associations between HAL and histidine, PAH and phenylalanine, and UPB1 and ureidopropionate using gene-based tests (P |
| DOI | 10.1038/ncomms12360 |
| Alternate Journal | Nat Commun |
| PubMed ID | 27453504 |
| PubMed Central ID | PMC4962516 |
| Grant List | R01 DK108159 / DK / NIDDK NIH HHS / United States HHSN268201100012C / HL / NHLBI NIH HHS / United States RC2 HL102419 / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States R01 HL098280 / HL / NHLBI NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States R01 HL081572 / HL / NHLBI NIH HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States K08 DK090142 / DK / NIDDK NIH HHS / United States R01 HL093328 / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States |