An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.

TitleAn Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.
Publication TypeJournal Article
Year of Publication2017
AuthorsScott, RA, Scott, LJ, Mägi, R, Marullo, L, Gaulton, KJ, Kaakinen, M, Pervjakova, N, Pers, TH, Johnson, AD, Eicher, JD, Jackson, AU, Ferreira, T, Lee, Y, Ma, C, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Van Zuydam, NR, Mahajan, A, Chen, H, Almgren, P, Voight, BF, Grallert, H, Müller-Nurasyid, M, Ried, JS, Rayner, NW, Robertson, N, Karssen, LC, van Leeuwen, EM, Willems, SM, Fuchsberger, C, Kwan, P, Teslovich, TM, Chanda, P, Li, M, Lu, Y, Dina, C, Thuillier, D, Yengo, L, Jiang, L, Sparso, T, Kestler, HA, Chheda, H, Eisele, L, Gustafsson, S, Frånberg, M, Strawbridge, RJ, Benediktsson, R, Hreidarsson, AB, Kong, A, Sigurðsson, G, Kerrison, ND, Luan, J'an, Liang, L, Meitinger, T, Roden, M, Thorand, B, Esko, T, Mihailov, E, Fox, C, Liu, C-T, Rybin, D, Isomaa, B, Lyssenko, V, Tuomi, T, Couper, DJ, Pankow, JS, Grarup, N, Have, CT, Jørgensen, ME, Jørgensen, T, Linneberg, A, Cornelis, MC, van Dam, RM, Hunter, DJ, Kraft, P, Sun, Q, Edkins, S, Owen, KR, Perry, JRB, Wood, AR, Zeggini, E, Tajes-Fernandes, J, Abecasis, GR, Bonnycastle, LL, Chines, PS, Stringham, HM, Koistinen, HA, Kinnunen, L, Sennblad, B, Mühleisen, TW, Nöthen, MM, Pechlivanis, S, Baldassarre, D, Gertow, K, Humphries, SE, Tremoli, E, Klopp, N, Meyer, J, Steinbach, G, Wennauer, R, Eriksson, JG, Mӓnnistö, S, Peltonen, L, Tikkanen, E, Charpentier, G, Eury, E, Lobbens, S, Gigante, B, Leander, K, McLeod, O, Bottinger, EP, Gottesman, O, Ruderfer, D, Blüher, M, Kovacs, P, Tonjes, A, Maruthur, NM, Scapoli, C, Erbel, R, Jöckel, K-H, Moebus, S, de Faire, U, Hamsten, A, Stumvoll, M, Deloukas, P, Donnelly, PJ, Frayling, TM, Hattersley, AT, Ripatti, S, Salomaa, V, Pedersen, NL, Boehm, BO, Bergman, RN, Collins, FS, Mohlke, KL, Tuomilehto, J, Hansen, T, Pedersen, O, Barroso, I, Lannfelt, L, Ingelsson, E, Lind, L, Lindgren, CM, Cauchi, S, Froguel, P, Loos, RJF, Balkau, B, Boeing, H, Franks, PW, Gurrea, ABarricarte, Palli, D, van der Schouw, YT, Altshuler, D, Groop, LC, Langenberg, C, Wareham, NJ, Sijbrands, E, van Duijn, CM, Florez, JC, Meigs, JB, Boerwinkle, E, Gieger, C, Strauch, K, Metspalu, A, Morris, AD, Palmer, CNA, Hu, FB, Thorsteinsdottir, U, Stefansson, K, Dupuis, J, Morris, AP, Boehnke, M, McCarthy, MI, Prokopenko, I
Corporate AuthorsDIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
JournalDiabetes
Volume66
Issue11
Pagination2888-2902
Date Published2017 11
ISSN1939-327X
KeywordsDiabetes Mellitus, Type 2, European Continental Ancestry Group, Gene Expression Regulation, Genetic Variation, Genome-Wide Association Study, Humans
Abstract

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association signals were followed up in additional data sets (of 14,545 or 7,397 T2D case and 38,994 or 71,604 control subjects). We identified 13 novel T2D-associated loci (

DOI10.2337/db16-1253
Alternate JournalDiabetes
PubMed ID28566273
PubMed Central IDPMC5652602
Grant ListN01HG65403 / HG / NHGRI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
S10 OD018522 / OD / NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
UM1 CA167552 / CA / NCI NIH HHS / United States
R01 AG033067 / AG / NIA NIH HHS / United States
G0601261 / MRC_ / Medical Research Council / United Kingdom
MR/M501633/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK093757 / DK / NIDDK NIH HHS / United States
R01 DK078616 / DK / NIDDK NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
U01 HG007417 / HG / NHGRI NIH HHS / United States
R01 DK073490 / DK / NIDDK NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
098017 / WT_ / Wellcome Trust / United Kingdom
R01 DK058845 / DK / NIDDK NIH HHS / United States
ZIA HG000024 / ImNIH / Intramural NIH HHS / United States
RG/08/008/25291 / BHF_ / British Heart Foundation / United Kingdom
UL1 RR025005 / RR / NCRR NIH HHS / United States
U01 DK085545 / DK / NIDDK NIH HHS / United States
R01 DK106236 / DK / NIDDK NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
R01 DK098032 / DK / NIDDK NIH HHS / United States
R01 DK072193 / DK / NIDDK NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
R01 HG000376 / HG / NHGRI NIH HHS / United States
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
U01 DK105535 / DK / NIDDK NIH HHS / United States
R01 DK101478 / DK / NIDDK NIH HHS / United States
P30 DK046200 / DK / NIDDK NIH HHS / United States
R01 AG028555 / AG / NIA NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
MC_UU_12015/2 / MRC_ / Medical Research Council / United Kingdom
RC2 DK088389 / DK / NIDDK NIH HHS / United States
K24 DK080140 / DK / NIDDK NIH HHS / United States
UM1 CA186107 / CA / NCI NIH HHS / United States
U01 DK085526 / DK / NIDDK NIH HHS / United States
P30 DK020541 / DK / NIDDK NIH HHS / United States
MR/M501633/2 / MRC_ / Medical Research Council / United Kingdom
U01 DK078616 / DK / NIDDK NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
P30 DK020572 / DK / NIDDK NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
RG/14/5/30893 / BHF_ / British Heart Foundation / United Kingdom
MR/K007017/1 / MRC_ / Medical Research Council / United Kingdom
/ WT_ / Wellcome Trust / United Kingdom
MC_PC_13040 / MRC_ / Medical Research Council / United Kingdom
R01 HL087641 / HL / NHLBI NIH HHS / United States
R01 AG010175 / AG / NIA NIH HHS / United States
U01 HG004399 / HG / NHGRI NIH HHS / United States