%0 Journal Article %J Acta Neurol Scand %D 2005 %T G309D and W437OPA PINK1 mutations in Caucasian Parkinson's disease patients. %A Deng, H %A Le, W D %A Zhang, X %A Pan, T H %A Jankovic, J %K Adult %K Amino Acid Substitution %K DNA Mutational Analysis %K Female %K Genetic Testing %K Genome, Human %K Humans %K Male %K Middle Aged %K Mutation %K Parkinson Disease %K Protein Kinases %K United States %K White People %X
OBJECTIVE: To determine whether the G309D and W437OPA mutations in PINK1 gene are present in American Caucasian population of patients with Parkinson's disease (PD).
METHODS: We searched for the G309D and W437OPA mutation by sequencing the regions of interest in the PINK1 gene in 237 unrelated Caucasian patients.
RESULTS: None of the 237 samples showed the G309D or W437OPA mutations.
CONCLUSIONS: The G309D and W437OPA mutations in PINK1 gene probably do not represent common causes of familial or sporadic PD in a Caucasian population.
%B Acta Neurol Scand %V 111 %P 351-2 %8 2005 Jun %G eng %N 6 %1 https://www.ncbi.nlm.nih.gov/pubmed/15876334?dopt=Abstract %R 10.1111/j.1600-0404.2005.00383.x