%0 Journal Article %J Science %D 2007 %T Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques. %A Hernandez, Ryan D %A Hubisz, Melissa J %A David A Wheeler %A Smith, David G %A Ferguson, Betsy %A Jeffrey Rogers %A Nazareth, Lynne %A Indap, Amit %A Bourquin, Traci %A McPherson, John %A Donna M Muzny %A Richard A Gibbs %A Nielsen, Rasmus %A Bustamante, Carlos D %K Animals %K China %K Demography %K DNA, Mitochondrial %K Genetics, Medical %K Humans %K India %K Linkage Disequilibrium %K Macaca mulatta %K Polymorphism, Single Nucleotide %X

To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r(2) approximately 0.15 at 10 kilobases) versus Indian (r(2) approximately 0.52 at 10 kilobases) macaque populations.

%B Science %V 316 %P 240-3 %8 2007 Apr 13 %G eng %N 5822 %1 https://www.ncbi.nlm.nih.gov/pubmed/17431170?dopt=Abstract %R 10.1126/science.1140462