%0 Journal Article %J J Autism Dev Disord %D 2018 %T Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children. %A Christian, MacKinsey A %A Samms-Vaughan, Maureen %A Lee, MinJae %A Bressler, Jan %A Hessabi, Manouchehr %A Grove, Megan L %A Shakespeare-Pellington, Sydonnie %A Coore Desai, Charlene %A Reece, Jody-Ann %A Loveland, Katherine A %A Eric Boerwinkle %A Rahbar, Mohammad H %K Adult %K Autism Spectrum Disorder %K Child %K Communicable Diseases %K Female %K Humans %K Jamaica %K Male %K Maternal Exposure %K Pesticides %K Pregnancy %K Volatile Organic Compounds %X

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD.

%B J Autism Dev Disord %V 48 %P 2766-2778 %8 2018 Aug %G eng %N 8 %1 https://www.ncbi.nlm.nih.gov/pubmed/29549549?dopt=Abstract %R 10.1007/s10803-018-3537-6