%0 Journal Article %J Nature %D 2022 %T Author Correction: Comparative and demographic analysis of orang-utan genomes. %A Locke, Devin P %A Hillier, LaDeana W %A Warren, Wesley C %A Kim C Worley %A Nazareth, Lynne V %A Donna M Muzny %A Yang, Shiaw-Pyng %A Wang, Zhengyuan %A Chinwalla, Asif T %A Minx, Pat %A Mitreva, Makedonka %A Cook, Lisa %A Delehaunty, Kim D %A Fronick, Catrina %A Schmidt, Heather %A Fulton, Lucinda A %A Fulton, Robert S %A Nelson, Joanne O %A Magrini, Vincent %A Pohl, Craig %A Graves, Tina A %A Markovic, Chris %A Cree, Andy %A Dinh, Huyen H %A Hume, Jennifer %A Kovar, Christie L %A Fowler, Gerald R %A Lunter, Gerton %A Meader, Stephen %A Heger, Andreas %A Ponting, Chris P %A Marques-Bonet, Tomas %A Alkan, Can %A Chen, Lin %A Cheng, Ze %A Kidd, Jeffrey M %A Eichler, Evan E %A White, Simon %A Searle, Stephen %A Vilella, Albert J %A Chen, Yuan %A Flicek, Paul %A Ma, Jian %A Raney, Brian %A Suh, Bernard %A Burhans, Richard %A Herrero, Javier %A Haussler, David %A Faria, Rui %A Fernando, Olga %A Darré, Fleur %A Farré, Domènec %A Gazave, Elodie %A Oliva, Meritxell %A Navarro, Arcadi %A Roberto, Roberta %A Capozzi, Oronzo %A Archidiacono, Nicoletta %A Della Valle, Giuliano %A Purgato, Stefania %A Rocchi, Mariano %A Konkel, Miriam K %A Walker, Jerilyn A %A Ullmer, Brygg %A Batzer, Mark A %A Smit, Arian F A %A Hubley, Robert %A Casola, Claudio %A Schrider, Daniel R %A Hahn, Matthew W %A Quesada, Victor %A Puente, Xose S %A Ordoñez, Gonzalo R %A López-Otín, Carlos %A Vinar, Tomas %A Brejova, Brona %A Ratan, Aakrosh %A Harris, Robert S %A Miller, Webb %A Kosiol, Carolin %A Lawson, Heather A %A Taliwal, Vikas %A Martins, André L %A Siepel, Adam %A Roychoudhury, Arindam %A Ma, Xin %A Degenhardt, Jeremiah %A Bustamante, Carlos D %A Gutenkunst, Ryan N %A Mailund, Thomas %A Dutheil, Julien Y %A Hobolth, Asger %A Schierup, Mikkel H %A Ryder, Oliver A %A Yoshinaga, Yuko %A De Jong, Pieter J %A Weinstock, George M %A Jeffrey Rogers %A Mardis, Elaine R %A Richard A Gibbs %A Wilson, Richard K %B Nature %V 608 %P E36 %8 2022 Aug %G eng %N 7924 %1 https://www.ncbi.nlm.nih.gov/pubmed/35962045?dopt=Abstract %R 10.1038/s41586-022-04799-7 %0 Journal Article %J Nature %D 2011 %T Comparative and demographic analysis of orang-utan genomes. %A Locke, Devin P %A Hillier, LaDeana W %A Warren, Wesley C %A Worley, Kim C %A Nazareth, Lynne V %A Muzny, Donna M %A Yang, Shiaw-Pyng %A Wang, Zhengyuan %A Chinwalla, Asif T %A Minx, Pat %A Mitreva, Makedonka %A Cook, Lisa %A Delehaunty, Kim D %A Fronick, Catrina %A Schmidt, Heather %A Fulton, Lucinda A %A Fulton, Robert S %A Nelson, Joanne O %A Magrini, Vincent %A Pohl, Craig %A Graves, Tina A %A Markovic, Chris %A Cree, Andy %A Dinh, Huyen H %A Hume, Jennifer %A Kovar, Christie L %A Fowler, Gerald R %A Lunter, Gerton %A Meader, Stephen %A Heger, Andreas %A Ponting, Chris P %A Marques-Bonet, Tomas %A Alkan, Can %A Chen, Lin %A Cheng, Ze %A Kidd, Jeffrey M %A Eichler, Evan E %A White, Simon %A Searle, Stephen %A Vilella, Albert J %A Chen, Yuan %A Flicek, Paul %A Ma, Jian %A Raney, Brian %A Suh, Bernard %A Burhans, Richard %A Herrero, Javier %A Haussler, David %A Faria, Rui %A Fernando, Olga %A Darré, Fleur %A Farré, Domènec %A Gazave, Elodie %A Oliva, Meritxell %A Navarro, Arcadi %A Roberto, Roberta %A Capozzi, Oronzo %A Archidiacono, Nicoletta %A Della Valle, Giuliano %A Purgato, Stefania %A Rocchi, Mariano %A Konkel, Miriam K %A Walker, Jerilyn A %A Ullmer, Brygg %A Batzer, Mark A %A Smit, Arian F A %A Hubley, Robert %A Casola, Claudio %A Schrider, Daniel R %A Hahn, Matthew W %A Quesada, Victor %A Puente, Xose S %A Ordoñez, Gonzalo R %A López-Otín, Carlos %A Vinar, Tomas %A Brejova, Brona %A Ratan, Aakrosh %A Harris, Robert S %A Miller, Webb %A Kosiol, Carolin %A Lawson, Heather A %A Taliwal, Vikas %A Martins, André L %A Siepel, Adam %A Roychoudhury, Arindam %A Ma, Xin %A Degenhardt, Jeremiah %A Bustamante, Carlos D %A Gutenkunst, Ryan N %A Mailund, Thomas %A Dutheil, Julien Y %A Hobolth, Asger %A Schierup, Mikkel H %A Ryder, Oliver A %A Yoshinaga, Yuko %A De Jong, Pieter J %A Weinstock, George M %A Rogers, Jeffrey %A Mardis, Elaine R %A Gibbs, Richard A %A Wilson, Richard K %K Animals %K Centromere %K Cerebrosides %K Chromosomes %K Evolution, Molecular %K Female %K Gene Rearrangement %K Genetic Speciation %K Genetic Variation %K Genetics, Population %K Genome %K Humans %K Male %K Phylogeny %K Pongo abelii %K Pongo pygmaeus %K Population Density %K Population Dynamics %K Species Specificity %X

'Orang-utan' is derived from a Malay term meaning 'man of the forest' and aptly describes the southeast Asian great apes native to Sumatra and Borneo. The orang-utan species, Pongo abelii (Sumatran) and Pongo pygmaeus (Bornean), are the most phylogenetically distant great apes from humans, thereby providing an informative perspective on hominid evolution. Here we present a Sumatran orang-utan draft genome assembly and short read sequence data from five Sumatran and five Bornean orang-utan genomes. Our analyses reveal that, compared to other primates, the orang-utan genome has many unique features. Structural evolution of the orang-utan genome has proceeded much more slowly than other great apes, evidenced by fewer rearrangements, less segmental duplication, a lower rate of gene family turnover and surprisingly quiescent Alu repeats, which have played a major role in restructuring other primate genomes. We also describe a primate polymorphic neocentromere, found in both Pongo species, emphasizing the gradual evolution of orang-utan genome structure. Orang-utans have extremely low energy usage for a eutherian mammal, far lower than their hominid relatives. Adding their genome to the repertoire of sequenced primates illuminates new signals of positive selection in several pathways including glycolipid metabolism. From the population perspective, both Pongo species are deeply diverse; however, Sumatran individuals possess greater diversity than their Bornean counterparts, and more species-specific variation. Our estimate of Bornean/Sumatran speciation time, 400,000 years ago, is more recent than most previous studies and underscores the complexity of the orang-utan speciation process. Despite a smaller modern census population size, the Sumatran effective population size (N(e)) expanded exponentially relative to the ancestral N(e) after the split, while Bornean N(e) declined over the same period. Overall, the resources and analyses presented here offer new opportunities in evolutionary genomics, insights into hominid biology, and an extensive database of variation for conservation efforts.

%B Nature %V 469 %P 529-33 %8 2011 Jan 27 %G eng %N 7331 %1 https://www.ncbi.nlm.nih.gov/pubmed/21270892?dopt=Abstract %R 10.1038/nature09687 %0 Journal Article %J Science %D 2007 %T Evolutionary and biomedical insights from the rhesus macaque genome. %A Richard A Gibbs %A Jeffrey Rogers %A Katze, Michael G %A Bumgarner, Roger %A Weinstock, George M %A Mardis, Elaine R %A Remington, Karin A %A Strausberg, Robert L %A Venter, J Craig %A Wilson, Richard K %A Batzer, Mark A %A Bustamante, Carlos D %A Eichler, Evan E %A Hahn, Matthew W %A Hardison, Ross C %A Makova, Kateryna D %A Miller, Webb %A Milosavljevic, Aleksandar %A Palermo, Robert E %A Siepel, Adam %A Sikela, James M %A Attaway, Tony %A Bell, Stephanie %A Bernard, Kelly E %A Buhay, Christian J %A Chandrabose, Mimi N %A Dao, Marvin %A Davis, Clay %A Delehaunty, Kimberly D %A Ding, Yan %A Dinh, Huyen H %A Dugan-Rocha, Shannon %A Fulton, Lucinda A %A Gabisi, Ramatu Ayiesha %A Garner, Toni T %A Godfrey, Jennifer %A Hawes, Alicia C %A Hernandez, Judith %A Hines, Sandra %A Holder, Michael %A Hume, Jennifer %A Jhangiani, Shalini N %A Joshi, Vandita %A Ziad Khan %A Kirkness, Ewen F %A Cree, Andrew %A Fowler, R Gerald %A Lee, Sandra %A Lewis, Lora R %A Li, Zhangwan %A Liu, Yih-Shin %A Moore, Stephanie M %A Donna M Muzny %A Nazareth, Lynne V %A Ngo, Dinh Ngoc %A Okwuonu, Geoffrey O %A Pai, Grace %A Parker, David %A Paul, Heidie A %A Pfannkoch, Cynthia %A Pohl, Craig S %A Rogers, Yu-Hui %A Ruiz, San Juana %A Aniko Sabo %A Santibanez, Jireh %A Schneider, Brian W %A Smith, Scott M %A Sodergren, Erica %A Svatek, Amanda F %A Utterback, Teresa R %A Vattathil, Selina %A Warren, Wesley %A White, Courtney Sherell %A Chinwalla, Asif T %A Feng, Yucheng %A Halpern, Aaron L %A Hillier, LaDeana W %A Huang, Xiaoqiu %A Minx, Pat %A Nelson, Joanne O %A Pepin, Kymberlie H %A Xiang Qin %A Sutton, Granger G %A Venter, Eli %A Walenz, Brian P %A Wallis, John W %A Kim C Worley %A Yang, Shiaw-Pyng %A Jones, Steven M %A Marra, Marco A %A Rocchi, Mariano %A Schein, Jacqueline E %A Baertsch, Robert %A Clarke, Laura %A Csuros, Miklos %A Glasscock, Jarret %A R. Alan Harris %A Havlak, Paul %A Jackson, Andrew R %A Jiang, Huaiyang %A Liu, Yue %A Messina, David N %A Shen, Yufeng %A Song, Henry Xing-Zhi %A Wylie, Todd %A Zhang, Lan %A Birney, Ewan %A Han, Kyudong %A Konkel, Miriam K %A Lee, Jungnam %A Smit, Arian F A %A Ullmer, Brygg %A Wang, Hui %A Xing, Jinchuan %A Burhans, Richard %A Cheng, Ze %A Karro, John E %A Ma, Jian %A Raney, Brian %A She, Xinwei %A Cox, Michael J %A Demuth, Jeffery P %A Dumas, Laura J %A Han, Sang-Gook %A Hopkins, Janet %A Karimpour-Fard, Anis %A Kim, Young H %A Pollack, Jonathan R %A Vinar, Tomas %A Addo-Quaye, Charles %A Degenhardt, Jeremiah %A Denby, Alexandra %A Hubisz, Melissa J %A Indap, Amit %A Kosiol, Carolin %A Lahn, Bruce T %A Lawson, Heather A %A Marklein, Alison %A Nielsen, Rasmus %A Vallender, Eric J %A Clark, Andrew G %A Ferguson, Betsy %A Hernandez, Ryan D %A Hirani, Kashif %A Kehrer-Sawatzki, Hildegard %A Kolb, Jessica %A Patil, Shobha %A Pu, Ling-Ling %A Ren, Yanru %A Smith, David Glenn %A David A Wheeler %A Schenck, Ian %A Ball, Edward V %A Rui Chen %A Cooper, David N %A Giardine, Belinda %A Hsu, Fan %A Kent, W James %A Lesk, Arthur %A Nelson, David L %A O'brien, William E %A Prüfer, Kay %A Stenson, Peter D %A Wallace, James C %A Ke, Hui %A Liu, Xiao-Ming %A Wang, Peng %A Xiang, Andy Peng %A Yang, Fan %A Barber, Galt P %A Haussler, David %A Karolchik, Donna %A Kern, Andy D %A Kuhn, Robert M %A Smith, Kayla E %A Zwieg, Ann S %K Animals %K Biomedical Research %K Evolution, Molecular %K Female %K Gene Duplication %K Gene Rearrangement %K Genetic Diseases, Inborn %K Genetic Variation %K Genome %K Humans %K Macaca mulatta %K Male %K Multigene Family %K Mutation %K Pan troglodytes %K Sequence Analysis, DNA %K Species Specificity %X

The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.

%B Science %V 316 %P 222-34 %8 2007 Apr 13 %G eng %N 5822 %1 https://www.ncbi.nlm.nih.gov/pubmed/17431167?dopt=Abstract %R 10.1126/science.1139247 %0 Journal Article %J Nature %D 2005 %T Generation and annotation of the DNA sequences of human chromosomes 2 and 4. %A Hillier, LaDeana W %A Graves, Tina A %A Fulton, Robert S %A Fulton, Lucinda A %A Pepin, Kymberlie H %A Minx, Patrick %A Wagner-McPherson, Caryn %A Layman, Dan %A Wylie, Kristine %A Sekhon, Mandeep %A Becker, Michael C %A Fewell, Ginger A %A Delehaunty, Kimberly D %A Miner, Tracie L %A Nash, William E %A Kremitzki, Colin %A Oddy, Lachlan %A Du, Hui %A Sun, Hui %A Bradshaw-Cordum, Holland %A Ali, Johar %A Carter, Jason %A Cordes, Matt %A Harris, Anthony %A Isak, Amber %A van Brunt, Andrew %A Nguyen, Christine %A Du, Feiyu %A Courtney, Laura %A Kalicki, Joelle %A Ozersky, Philip %A Abbott, Scott %A Armstrong, Jon %A Belter, Edward A %A Caruso, Lauren %A Cedroni, Maria %A Cotton, Marc %A Davidson, Teresa %A Desai, Anu %A Elliott, Glendoria %A Erb, Thomas %A Fronick, Catrina %A Gaige, Tony %A Haakenson, William %A Haglund, Krista %A Holmes, Andrea %A Harkins, Richard %A Kim, Kyung %A Kruchowski, Scott S %A Strong, Cynthia Madsen %A Grewal, Neenu %A Goyea, Ernest %A Hou, Shunfang %A Levy, Andrew %A Martinka, Scott %A Mead, Kelly %A McLellan, Michael D %A Meyer, Rick %A Randall-Maher, Jennifer %A Tomlinson, Chad %A Dauphin-Kohlberg, Sara %A Kozlowicz-Reilly, Amy %A Shah, Neha %A Swearengen-Shahid, Sharhonda %A Snider, Jacqueline %A Strong, Joseph T %A Thompson, Johanna %A Yoakum, Martin %A Leonard, Shawn %A Pearman, Charlene %A Trani, Lee %A Radionenko, Maxim %A Waligorski, Jason E %A Wang, Chunyan %A Rock, Susan M %A Tin-Wollam, Aye-Mon %A Maupin, Rachel %A Latreille, Phil %A Wendl, Michael C %A Yang, Shiaw-Pyng %A Pohl, Craig %A Wallis, John W %A Spieth, John %A Bieri, Tamberlyn A %A Berkowicz, Nicolas %A Nelson, Joanne O %A Osborne, John %A Ding, Li %A Meyer, Rekha %A Aniko Sabo %A Shotland, Yoram %A Sinha, Prashant %A Wohldmann, Patricia E %A Cook, Lisa L %A Hickenbotham, Matthew T %A Eldred, James %A Williams, Donald %A Jones, Thomas A %A She, Xinwei %A Ciccarelli, Francesca D %A Izaurralde, Elisa %A Taylor, James %A Schmutz, Jeremy %A Myers, Richard M %A Cox, David R %A Huang, Xiaoqiu %A McPherson, John D %A Mardis, Elaine R %A Clifton, Sandra W %A Warren, Wesley C %A Chinwalla, Asif T %A Eddy, Sean R %A Marra, Marco A %A Ovcharenko, Ivan %A Furey, Terrence S %A Miller, Webb %A Eichler, Evan E %A Bork, Peer %A Suyama, Mikita %A Torrents, David %A Waterston, Robert H %A Wilson, Richard K %K Animals %K Base Composition %K Base Sequence %K Centromere %K Chromosomes, Human, Pair 2 %K Chromosomes, Human, Pair 4 %K Conserved Sequence %K CpG Islands %K Euchromatin %K Expressed Sequence Tags %K Gene Duplication %K Genetic Variation %K Genomics %K Humans %K Molecular Sequence Data %K Physical Chromosome Mapping %K Polymorphism, Genetic %K Primates %K Proteins %K Pseudogenes %K Recombination, Genetic %K RNA, Messenger %K RNA, Untranslated %K Sequence Analysis, DNA %X

Human chromosome 2 is unique to the human lineage in being the product of a head-to-head fusion of two intermediate-sized ancestral chromosomes. Chromosome 4 has received attention primarily related to the search for the Huntington's disease gene, but also for genes associated with Wolf-Hirschhorn syndrome, polycystic kidney disease and a form of muscular dystrophy. Here we present approximately 237 million base pairs of sequence for chromosome 2, and 186 million base pairs for chromosome 4, representing more than 99.6% of their euchromatic sequences. Our initial analyses have identified 1,346 protein-coding genes and 1,239 pseudogenes on chromosome 2, and 796 protein-coding genes and 778 pseudogenes on chromosome 4. Extensive analyses confirm the underlying construction of the sequence, and expand our understanding of the structure and evolution of mammalian chromosomes, including gene deserts, segmental duplications and highly variant regions.

%B Nature %V 434 %P 724-31 %8 2005 Apr 07 %G eng %N 7034 %1 https://www.ncbi.nlm.nih.gov/pubmed/15815621?dopt=Abstract %R 10.1038/nature03466 %0 Journal Article %J Nature %D 2003 %T The DNA sequence of human chromosome 7. %A Hillier, LaDeana W %A Fulton, Robert S %A Fulton, Lucinda A %A Graves, Tina A %A Pepin, Kymberlie H %A Wagner-McPherson, Caryn %A Layman, Dan %A Maas, Jason %A Jaeger, Sara %A Walker, Rebecca %A Wylie, Kristine %A Sekhon, Mandeep %A Becker, Michael C %A O'Laughlin, Michelle D %A Schaller, Mark E %A Fewell, Ginger A %A Delehaunty, Kimberly D %A Miner, Tracie L %A Nash, William E %A Cordes, Matt %A Du, Hui %A Sun, Hui %A Edwards, Jennifer %A Bradshaw-Cordum, Holland %A Ali, Johar %A Andrews, Stephanie %A Isak, Amber %A Vanbrunt, Andrew %A Nguyen, Christine %A Du, Feiyu %A Lamar, Betty %A Courtney, Laura %A Kalicki, Joelle %A Ozersky, Philip %A Bielicki, Lauren %A Scott, Kelsi %A Holmes, Andrea %A Harkins, Richard %A Harris, Anthony %A Strong, Cynthia Madsen %A Hou, Shunfang %A Tomlinson, Chad %A Dauphin-Kohlberg, Sara %A Kozlowicz-Reilly, Amy %A Leonard, Shawn %A Rohlfing, Theresa %A Rock, Susan M %A Tin-Wollam, Aye-Mon %A Abbott, Amanda %A Minx, Patrick %A Maupin, Rachel %A Strowmatt, Catrina %A Latreille, Phil %A Miller, Nancy %A Johnson, Doug %A Murray, Jennifer %A Woessner, Jeffrey P %A Wendl, Michael C %A Yang, Shiaw-Pyng %A Schultz, Brian R %A Wallis, John W %A Spieth, John %A Bieri, Tamberlyn A %A Nelson, Joanne O %A Berkowicz, Nicolas %A Wohldmann, Patricia E %A Cook, Lisa L %A Hickenbotham, Matthew T %A Eldred, James %A Williams, Donald %A Bedell, Joseph A %A Mardis, Elaine R %A Clifton, Sandra W %A Chissoe, Stephanie L %A Marra, Marco A %A Raymond, Christopher %A Haugen, Eric %A Gillett, Will %A Zhou, Yang %A James, Rose %A Phelps, Karen %A Iadanoto, Shawn %A Bubb, Kerry %A Simms, Elizabeth %A Levy, Ruth %A Clendenning, James %A Kaul, Rajinder %A Kent, W James %A Furey, Terrence S %A Baertsch, Robert A %A Brent, Michael R %A Keibler, Evan %A Flicek, Paul %A Bork, Peer %A Suyama, Mikita %A Bailey, Jeffrey A %A Portnoy, Matthew E %A Torrents, David %A Chinwalla, Asif T %A Gish, Warren R %A Eddy, Sean R %A McPherson, John D %A Olson, Maynard V %A Eichler, Evan E %A Green, Eric D %A Waterston, Robert H %A Wilson, Richard K %K Animals %K Base Sequence %K Chromosomes, Human, Pair 7 %K Gene Duplication %K Humans %K Mice %K Molecular Sequence Data %K Physical Chromosome Mapping %K Proteins %K Pseudogenes %K RNA, Untranslated %K Sequence Analysis, DNA %K Species Specificity %K Williams Syndrome %X

Human chromosome 7 has historically received prominent attention in the human genetics community, primarily related to the search for the cystic fibrosis gene and the frequent cytogenetic changes associated with various forms of cancer. Here we present more than 153 million base pairs representing 99.4% of the euchromatic sequence of chromosome 7, the first metacentric chromosome completed so far. The sequence has excellent concordance with previously established physical and genetic maps, and it exhibits an unusual amount of segmentally duplicated sequence (8.2%), with marked differences between the two arms. Our initial analyses have identified 1,150 protein-coding genes, 605 of which have been confirmed by complementary DNA sequences, and an additional 941 pseudogenes. Of genes confirmed by transcript sequences, some are polymorphic for mutations that disrupt the reading frame.

%B Nature %V 424 %P 157-64 %8 2003 Jul 10 %G eng %N 6945 %1 https://www.ncbi.nlm.nih.gov/pubmed/12853948?dopt=Abstract %R 10.1038/nature01782 %0 Journal Article %J Nature %D 2002 %T Initial sequencing and comparative analysis of the mouse genome. %A Waterston, Robert H %A Lindblad-Toh, Kerstin %A Birney, Ewan %A Rogers, Jane %A Abril, Josep F %A Agarwal, Pankaj %A Agarwala, Richa %A Ainscough, Rachel %A Alexandersson, Marina %A An, Peter %A Antonarakis, Stylianos E %A Attwood, John %A Baertsch, Robert %A Bailey, Jonathon %A Barlow, Karen %A Beck, Stephan %A Berry, Eric %A Birren, Bruce %A Bloom, Toby %A Bork, Peer %A Botcherby, Marc %A Bray, Nicolas %A Brent, Michael R %A Brown, Daniel G %A Brown, Stephen D %A Bult, Carol %A Burton, John %A Butler, Jonathan %A Campbell, Robert D %A Carninci, Piero %A Cawley, Simon %A Chiaromonte, Francesca %A Chinwalla, Asif T %A Church, Deanna M %A Clamp, Michele %A Clee, Christopher %A Collins, Francis S %A Cook, Lisa L %A Copley, Richard R %A Coulson, Alan %A Couronne, Olivier %A Cuff, James %A Curwen, Val %A Cutts, Tim %A Daly, Mark %A David, Robert %A Davies, Joy %A Delehaunty, Kimberly D %A Deri, Justin %A Dermitzakis, Emmanouil T %A Dewey, Colin %A Dickens, Nicholas J %A Diekhans, Mark %A Dodge, Sheila %A Dubchak, Inna %A Dunn, Diane M %A Eddy, Sean R %A Elnitski, Laura %A Emes, Richard D %A Eswara, Pallavi %A Eyras, Eduardo %A Felsenfeld, Adam %A Fewell, Ginger A %A Flicek, Paul %A Foley, Karen %A Frankel, Wayne N %A Fulton, Lucinda A %A Fulton, Robert S %A Furey, Terrence S %A Gage, Diane %A Gibbs, Richard A %A Glusman, Gustavo %A Gnerre, Sante %A Goldman, Nick %A Goodstadt, Leo %A Grafham, Darren %A Graves, Tina A %A Green, Eric D %A Gregory, Simon %A Guigó, Roderic %A Guyer, Mark %A Hardison, Ross C %A Haussler, David %A Hayashizaki, Yoshihide %A Hillier, LaDeana W %A Hinrichs, Angela %A Hlavina, Wratko %A Holzer, Timothy %A Hsu, Fan %A Hua, Axin %A Hubbard, Tim %A Hunt, Adrienne %A Jackson, Ian %A Jaffe, David B %A Johnson, L Steven %A Jones, Matthew %A Jones, Thomas A %A Joy, Ann %A Kamal, Michael %A Karlsson, Elinor K %A Karolchik, Donna %A Kasprzyk, Arkadiusz %A Kawai, Jun %A Keibler, Evan %A Kells, Cristyn %A Kent, W James %A Kirby, Andrew %A Kolbe, Diana L %A Korf, Ian %A Kucherlapati, Raju S %A Kulbokas, Edward J %A Kulp, David %A Landers, Tom %A Leger, J P %A Leonard, Steven %A Letunic, Ivica %A Levine, Rosie %A Li, Jia %A Li, Ming %A Lloyd, Christine %A Lucas, Susan %A Ma, Bin %A Maglott, Donna R %A Mardis, Elaine R %A Matthews, Lucy %A Mauceli, Evan %A Mayer, John H %A McCarthy, Megan %A McCombie, W Richard %A McLaren, Stuart %A McLay, Kirsten %A McPherson, John D %A Meldrim, Jim %A Meredith, Beverley %A Mesirov, Jill P %A Miller, Webb %A Miner, Tracie L %A Mongin, Emmanuel %A Montgomery, Kate T %A Morgan, Michael %A Mott, Richard %A Mullikin, James C %A Muzny, Donna M %A Nash, William E %A Nelson, Joanne O %A Nhan, Michael N %A Nicol, Robert %A Ning, Zemin %A Nusbaum, Chad %A O'Connor, Michael J %A Okazaki, Yasushi %A Oliver, Karen %A Overton-Larty, Emma %A Pachter, Lior %A Parra, Genís %A Pepin, Kymberlie H %A Peterson, Jane %A Pevzner, Pavel %A Plumb, Robert %A Pohl, Craig S %A Poliakov, Alex %A Ponce, Tracy C %A Ponting, Chris P %A Potter, Simon %A Quail, Michael %A Reymond, Alexandre %A Roe, Bruce A %A Roskin, Krishna M %A Rubin, Edward M %A Rust, Alistair G %A Santos, Ralph %A Sapojnikov, Victor %A Schultz, Brian %A Schultz, Jörg %A Schwartz, Matthias S %A Schwartz, Scott %A Scott, Carol %A Seaman, Steven %A Searle, Steve %A Sharpe, Ted %A Sheridan, Andrew %A Shownkeen, Ratna %A Sims, Sarah %A Singer, Jonathan B %A Slater, Guy %A Smit, Arian %A Smith, Douglas R %A Spencer, Brian %A Stabenau, Arne %A Stange-Thomann, Nicole %A Sugnet, Charles %A Suyama, Mikita %A Tesler, Glenn %A Thompson, Johanna %A Torrents, David %A Trevaskis, Evanne %A Tromp, John %A Ucla, Catherine %A Ureta-Vidal, Abel %A Vinson, Jade P %A Von Niederhausern, Andrew C %A Wade, Claire M %A Wall, Melanie %A Weber, Ryan J %A Weiss, Robert B %A Wendl, Michael C %A West, Anthony P %A Wetterstrand, Kris %A Wheeler, Raymond %A Whelan, Simon %A Wierzbowski, Jamey %A Willey, David %A Williams, Sophie %A Wilson, Richard K %A Winter, Eitan %A Worley, Kim C %A Wyman, Dudley %A Yang, Shan %A Yang, Shiaw-Pyng %A Zdobnov, Evgeny M %A Zody, Michael C %A Lander, Eric S %K Animals %K Base Composition %K Chromosomes, Mammalian %K Conserved Sequence %K CpG Islands %K Evolution, Molecular %K Gene Expression Regulation %K Genes %K Genetic Variation %K Genome %K Genome, Human %K Genomics %K Humans %K Mice %K Mice, Knockout %K Mice, Transgenic %K Models, Animal %K Multigene Family %K Mutagenesis %K Neoplasms %K Physical Chromosome Mapping %K Proteome %K Pseudogenes %K Quantitative Trait Loci %K Repetitive Sequences, Nucleic Acid %K RNA, Untranslated %K Selection, Genetic %K Sequence Analysis, DNA %K Sex Chromosomes %K Species Specificity %K Synteny %X

The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.

%B Nature %V 420 %P 520-62 %8 2002 Dec 05 %G eng %N 6915 %1 https://www.ncbi.nlm.nih.gov/pubmed/12466850?dopt=Abstract %R 10.1038/nature01262