%0 Journal Article %J Cell Rep %D 2017 %T Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles. %A Farshidfar, Farshad %A Zheng, Siyuan %A Gingras, Marie-Claude %A Newton, Yulia %A Shih, Juliann %A Robertson, A Gordon %A Hinoue, Toshinori %A Hoadley, Katherine A %A Gibb, Ewan A %A Roszik, Jason %A Covington, Kyle R %A Wu, Chia-Chin %A Shinbrot, Eve %A Stransky, Nicolas %A Hegde, Apurva %A Yang, Ju Dong %A Reznik, Ed %A Sadeghi, Sara %A Pedamallu, Chandra Sekhar %A Ojesina, Akinyemi I %A Hess, Julian M %A Auman, J Todd %A Rhie, Suhn K %A Bowlby, Reanne %A Borad, Mitesh J %A Zhu, Andrew X %A Stuart, Josh M %A Sander, Chris %A Akbani, Rehan %A Cherniack, Andrew D %A Deshpande, Vikram %A Mounajjed, Taofic %A Foo, Wai Chin %A Torbenson, Michael S %A Kleiner, David E %A Laird, Peter W %A Wheeler, David A %A McRee, Autumn J %A Bathe, Oliver F %A Andersen, Jesper B %A Bardeesy, Nabeel %A Roberts, Lewis R %A Kwong, Lawrence N %K Adult %K Aged %K Aged, 80 and over %K Bile Duct Neoplasms %K Cholangiocarcinoma %K Chromatin %K DNA Methylation %K DNA-Binding Proteins %K Female %K Gene Expression Regulation, Neoplastic %K Genomics %K Humans %K Isocitrate Dehydrogenase %K Liver %K Liver Neoplasms %K Male %K Middle Aged %K Mitochondria %K Mutation %K Nuclear Proteins %K Pancreatic Neoplasms %K Promoter Regions, Genetic %K RNA, Long Noncoding %K RNA, Messenger %K Transcription Factors %X

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer Genome Atlas of a set of predominantly intrahepatic CCA cases and propose a molecular classification scheme. We identified an IDH mutant-enriched subtype with distinct molecular features including low expression of chromatin modifiers, elevated expression of mitochondrial genes, and increased mitochondrial DNA copy number. Leveraging the multi-platform data, we observed that ARID1A exhibited DNA hypermethylation and decreased expression in the IDH mutant subtype. More broadly, we found that IDH mutations are associated with an expanded histological spectrum of liver tumors with molecular features that stratify with CCA. Our studies reveal insights into the molecular pathogenesis and heterogeneity of cholangiocarcinoma and provide classification information of potential therapeutic significance.

%B Cell Rep %V 18 %P 2780-2794 %8 2017 Mar 14 %G eng %N 11 %1 https://www.ncbi.nlm.nih.gov/pubmed/28297679?dopt=Abstract %R 10.1016/j.celrep.2017.02.033