%0 Journal Article %J Nat Genet %D 2021 %T Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. %A Surendran, Praveen %A Feofanova, Elena V %A Lahrouchi, Najim %A Ntalla, Ioanna %A Karthikeyan, Savita %A Cook, James %A Chen, Lingyan %A Mifsud, Borbala %A Yao, Chen %A Kraja, Aldi T %A Cartwright, James H %A Hellwege, Jacklyn N %A Giri, Ayush %A Tragante, Vinicius %A Thorleifsson, Gudmar %A Liu, Dajiang J %A Prins, Bram P %A Stewart, Isobel D %A Cabrera, Claudia P %A Eales, James M %A Akbarov, Artur %A Auer, Paul L %A Bielak, Lawrence F %A Bis, Joshua C %A Braithwaite, Vickie S %A Brody, Jennifer A %A Daw, E Warwick %A Warren, Helen R %A Drenos, Fotios %A Nielsen, Sune Fallgaard %A Faul, Jessica D %A Fauman, Eric B %A Fava, Cristiano %A Ferreira, Teresa %A Foley, Christopher N %A Franceschini, Nora %A Gao, He %A Giannakopoulou, Olga %A Giulianini, Franco %A Gudbjartsson, Daniel F %A Guo, Xiuqing %A Harris, Sarah E %A Havulinna, Aki S %A Helgadottir, Anna %A Huffman, Jennifer E %A Hwang, Shih-Jen %A Kanoni, Stavroula %A Kontto, Jukka %A Larson, Martin G %A Li-Gao, Ruifang %A Lindström, Jaana %A Lotta, Luca A %A Lu, Yingchang %A Luan, Jian'an %A Mahajan, Anubha %A Malerba, Giovanni %A Masca, Nicholas G D %A Mei, Hao %A Menni, Cristina %A Mook-Kanamori, Dennis O %A Mosen-Ansorena, David %A Müller-Nurasyid, Martina %A Paré, Guillaume %A Paul, Dirk S %A Perola, Markus %A Poveda, Alaitz %A Rauramaa, Rainer %A Richard, Melissa %A Richardson, Tom G %A Sepúlveda, Nuno %A Sim, Xueling %A Smith, Albert V %A Smith, Jennifer A %A Staley, James R %A Stanáková, Alena %A Sulem, Patrick %A Thériault, Sébastien %A Thorsteinsdottir, Unnur %A Trompet, Stella %A Varga, Tibor V %A Velez Edwards, Digna R %A Veronesi, Giovanni %A Weiss, Stefan %A Willems, Sara M %A Yao, Jie %A Young, Robin %A Yu, Bing %A Zhang, Weihua %A Zhao, Jing-Hua %A Zhao, Wei %A Zhao, Wei %A Evangelou, Evangelos %A Aeschbacher, Stefanie %A Asllanaj, Eralda %A Blankenberg, Stefan %A Bonnycastle, Lori L %A Bork-Jensen, Jette %A Brandslund, Ivan %A Braund, Peter S %A Burgess, Stephen %A Cho, Kelly %A Christensen, Cramer %A Connell, John %A Mutsert, Renée de %A Dominiczak, Anna F %A Dörr, Marcus %A Eiriksdottir, Gudny %A Farmaki, Aliki-Eleni %A Gaziano, J Michael %A Grarup, Niels %A Grove, Megan L %A Hallmans, Goran %A Hansen, Torben %A Have, Christian T %A Heiss, Gerardo %A Jørgensen, Marit E %A Jousilahti, Pekka %A Kajantie, Eero %A Kamat, Mihir %A Käräjämäki, Annemari %A Karpe, Fredrik %A Koistinen, Heikki A %A Kovesdy, Csaba P %A Kuulasmaa, Kari %A Laatikainen, Tiina %A Lannfelt, Lars %A Lee, I-Te %A Lee, Wen-Jane %A Linneberg, Allan %A Martin, Lisa W %A Moitry, Marie %A Nadkarni, Girish %A Neville, Matt J %A Palmer, Colin N A %A Papanicolaou, George J %A Pedersen, Oluf %A Peters, James %A Poulter, Neil %A Rasheed, Asif %A Rasmussen, Katrine L %A Rayner, N William %A Mägi, Reedik %A Renstrom, Frida %A Rettig, Rainer %A Rossouw, Jacques %A Schreiner, Pamela J %A Sever, Peter S %A Sigurdsson, Emil L %A Skaaby, Tea %A Sun, Yan V %A Sundström, Johan %A Thorgeirsson, Gudmundur %A Esko, Tõnu %A Trabetti, Elisabetta %A Tsao, Philip S %A Tuomi, Tiinamaija %A Turner, Stephen T %A Tzoulaki, Ioanna %A Vaartjes, Ilonca %A Vergnaud, Anne-Claire %A Willer, Cristen J %A Wilson, Peter W F %A Witte, Daniel R %A Yonova-Doing, Ekaterina %A Zhang, He %A Aliya, Naheed %A Almgren, Peter %A Amouyel, Philippe %A Asselbergs, Folkert W %A Barnes, Michael R %A Blakemore, Alexandra I %A Boehnke, Michael %A Bots, Michiel L %A Bottinger, Erwin P %A Buring, Julie E %A Chambers, John C %A Chen, Yii-Der Ida %A Chowdhury, Rajiv %A Conen, David %A Correa, Adolfo %A Davey Smith, George %A Boer, Rudolf A de %A Deary, Ian J %A Dedoussis, George %A Deloukas, Panos %A Di Angelantonio, Emanuele %A Elliott, Paul %A Felix, Stephan B %A Ferrieres, Jean %A Ford, Ian %A Fornage, Myriam %A Franks, Paul W %A Franks, Stephen %A Frossard, Philippe %A Gambaro, Giovanni %A Gaunt, Tom R %A Groop, Leif %A Gudnason, Vilmundur %A Harris, Tamara B %A Hayward, Caroline %A Hennig, Branwen J %A Herzig, Karl-Heinz %A Ingelsson, Erik %A Tuomilehto, Jaakko %A Jarvelin, Marjo-Riitta %A Jukema, J Wouter %A Kardia, Sharon L R %A Kee, Frank %A Kooner, Jaspal S %A Kooperberg, Charles %A Launer, Lenore J %A Lind, Lars %A Loos, Ruth J F %A Majumder, Abdulla Al Shafi %A Laakso, Markku %A McCarthy, Mark I %A Melander, Olle %A Mohlke, Karen L %A Murray, Alison D %A Nordestgaard, Børge Grønne %A Orho-Melander, Marju %A Packard, Chris J %A Padmanabhan, Sandosh %A Palmas, Walter %A Polasek, Ozren %A Porteous, David J %A Prentice, Andrew M %A Province, Michael A %A Relton, Caroline L %A Rice, Kenneth %A Ridker, Paul M %A Rolandsson, Olov %A Rosendaal, Frits R %A Rotter, Jerome I %A Rudan, Igor %A Salomaa, Veikko %A Samani, Nilesh J %A Sattar, Naveed %A Sheu, Wayne H-H %A Smith, Blair H %A Soranzo, Nicole %A Spector, Timothy D %A Starr, John M %A Sebert, Sylvain %A Taylor, Kent D %A Lakka, Timo A %A Timpson, Nicholas J %A Tobin, Martin D %A van der Harst, Pim %A van der Meer, Peter %A Ramachandran, Vasan S %A Verweij, Niek %A Virtamo, Jarmo %A Völker, Uwe %A Weir, David R %A Zeggini, Eleftheria %A Charchar, Fadi J %A Wareham, Nicholas J %A Langenberg, Claudia %A Tomaszewski, Maciej %A Butterworth, Adam S %A Caulfield, Mark J %A Danesh, John %A Edwards, Todd L %A Holm, Hilma %A Hung, Adriana M %A Lindgren, Cecilia M %A Liu, Chunyu %A Manning, Alisa K %A Morris, Andrew P %A Morrison, Alanna C %A O'Donnell, Christopher J %A Psaty, Bruce M %A Saleheen, Danish %A Stefansson, Kari %A Eric Boerwinkle %A Chasman, Daniel I %A Levy, Daniel %A Newton-Cheh, Christopher %A Munroe, Patricia B %A Howson, Joanna M M %B Nat Genet %V 53 %P 762 %8 2021 May %G eng %N 5 %1 https://www.ncbi.nlm.nih.gov/pubmed/33727701?dopt=Abstract %R 10.1038/s41588-021-00832-z %0 Journal Article %J Nat Genet %D 2020 %T Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. %A Surendran, Praveen %A Feofanova, Elena V %A Lahrouchi, Najim %A Ntalla, Ioanna %A Karthikeyan, Savita %A Cook, James %A Chen, Lingyan %A Mifsud, Borbala %A Yao, Chen %A Kraja, Aldi T %A Cartwright, James H %A Hellwege, Jacklyn N %A Giri, Ayush %A Tragante, Vinicius %A Thorleifsson, Gudmar %A Liu, Dajiang J %A Prins, Bram P %A Stewart, Isobel D %A Cabrera, Claudia P %A Eales, James M %A Akbarov, Artur %A Auer, Paul L %A Bielak, Lawrence F %A Bis, Joshua C %A Braithwaite, Vickie S %A Brody, Jennifer A %A Daw, E Warwick %A Warren, Helen R %A Drenos, Fotios %A Nielsen, Sune Fallgaard %A Faul, Jessica D %A Fauman, Eric B %A Fava, Cristiano %A Ferreira, Teresa %A Foley, Christopher N %A Franceschini, Nora %A Gao, He %A Giannakopoulou, Olga %A Giulianini, Franco %A Gudbjartsson, Daniel F %A Guo, Xiuqing %A Harris, Sarah E %A Havulinna, Aki S %A Helgadottir, Anna %A Huffman, Jennifer E %A Hwang, Shih-Jen %A Kanoni, Stavroula %A Kontto, Jukka %A Larson, Martin G %A Li-Gao, Ruifang %A Lindström, Jaana %A Lotta, Luca A %A Lu, Yingchang %A Luan, Jian'an %A Mahajan, Anubha %A Malerba, Giovanni %A Masca, Nicholas G D %A Mei, Hao %A Menni, Cristina %A Mook-Kanamori, Dennis O %A Mosen-Ansorena, David %A Müller-Nurasyid, Martina %A Paré, Guillaume %A Paul, Dirk S %A Perola, Markus %A Poveda, Alaitz %A Rauramaa, Rainer %A Richard, Melissa %A Richardson, Tom G %A Sepúlveda, Nuno %A Sim, Xueling %A Smith, Albert V %A Smith, Jennifer A %A Staley, James R %A Stanáková, Alena %A Sulem, Patrick %A Thériault, Sébastien %A Thorsteinsdottir, Unnur %A Trompet, Stella %A Varga, Tibor V %A Velez Edwards, Digna R %A Veronesi, Giovanni %A Weiss, Stefan %A Willems, Sara M %A Yao, Jie %A Young, Robin %A Yu, Bing %A Zhang, Weihua %A Zhao, Jing-Hua %A Zhao, Wei %A Zhao, Wei %A Evangelou, Evangelos %A Aeschbacher, Stefanie %A Asllanaj, Eralda %A Blankenberg, Stefan %A Bonnycastle, Lori L %A Bork-Jensen, Jette %A Brandslund, Ivan %A Braund, Peter S %A Burgess, Stephen %A Cho, Kelly %A Christensen, Cramer %A Connell, John %A Mutsert, Renée de %A Dominiczak, Anna F %A Dörr, Marcus %A Eiriksdottir, Gudny %A Farmaki, Aliki-Eleni %A Gaziano, J Michael %A Grarup, Niels %A Grove, Megan L %A Hallmans, Goran %A Hansen, Torben %A Have, Christian T %A Heiss, Gerardo %A Jørgensen, Marit E %A Jousilahti, Pekka %A Kajantie, Eero %A Kamat, Mihir %A Käräjämäki, Annemari %A Karpe, Fredrik %A Koistinen, Heikki A %A Kovesdy, Csaba P %A Kuulasmaa, Kari %A Laatikainen, Tiina %A Lannfelt, Lars %A Lee, I-Te %A Lee, Wen-Jane %A Linneberg, Allan %A Martin, Lisa W %A Moitry, Marie %A Nadkarni, Girish %A Neville, Matt J %A Palmer, Colin N A %A Papanicolaou, George J %A Pedersen, Oluf %A Peters, James %A Poulter, Neil %A Rasheed, Asif %A Rasmussen, Katrine L %A Rayner, N William %A Mägi, Reedik %A Renstrom, Frida %A Rettig, Rainer %A Rossouw, Jacques %A Schreiner, Pamela J %A Sever, Peter S %A Sigurdsson, Emil L %A Skaaby, Tea %A Sun, Yan V %A Sundström, Johan %A Thorgeirsson, Gudmundur %A Esko, Tõnu %A Trabetti, Elisabetta %A Tsao, Philip S %A Tuomi, Tiinamaija %A Turner, Stephen T %A Tzoulaki, Ioanna %A Vaartjes, Ilonca %A Vergnaud, Anne-Claire %A Willer, Cristen J %A Wilson, Peter W F %A Witte, Daniel R %A Yonova-Doing, Ekaterina %A Zhang, He %A Aliya, Naheed %A Almgren, Peter %A Amouyel, Philippe %A Asselbergs, Folkert W %A Barnes, Michael R %A Blakemore, Alexandra I %A Boehnke, Michael %A Bots, Michiel L %A Bottinger, Erwin P %A Buring, Julie E %A Chambers, John C %A Chen, Yii-Der Ida %A Chowdhury, Rajiv %A Conen, David %A Correa, Adolfo %A Davey Smith, George %A Boer, Rudolf A de %A Deary, Ian J %A Dedoussis, George %A Deloukas, Panos %A Di Angelantonio, Emanuele %A Elliott, Paul %A Felix, Stephan B %A Ferrieres, Jean %A Ford, Ian %A Fornage, Myriam %A Franks, Paul W %A Franks, Stephen %A Frossard, Philippe %A Gambaro, Giovanni %A Gaunt, Tom R %A Groop, Leif %A Gudnason, Vilmundur %A Harris, Tamara B %A Hayward, Caroline %A Hennig, Branwen J %A Herzig, Karl-Heinz %A Ingelsson, Erik %A Tuomilehto, Jaakko %A Jarvelin, Marjo-Riitta %A Jukema, J Wouter %A Kardia, Sharon L R %A Kee, Frank %A Kooner, Jaspal S %A Kooperberg, Charles %A Launer, Lenore J %A Lind, Lars %A Loos, Ruth J F %A Majumder, Abdulla Al Shafi %A Laakso, Markku %A McCarthy, Mark I %A Melander, Olle %A Mohlke, Karen L %A Murray, Alison D %A Nordestgaard, Børge Grønne %A Orho-Melander, Marju %A Packard, Chris J %A Padmanabhan, Sandosh %A Palmas, Walter %A Polasek, Ozren %A Porteous, David J %A Prentice, Andrew M %A Province, Michael A %A Relton, Caroline L %A Rice, Kenneth %A Ridker, Paul M %A Rolandsson, Olov %A Rosendaal, Frits R %A Rotter, Jerome I %A Rudan, Igor %A Salomaa, Veikko %A Samani, Nilesh J %A Sattar, Naveed %A Sheu, Wayne H-H %A Smith, Blair H %A Soranzo, Nicole %A Spector, Timothy D %A Starr, John M %A Sebert, Sylvain %A Taylor, Kent D %A Lakka, Timo A %A Timpson, Nicholas J %A Tobin, Martin D %A van der Harst, Pim %A van der Meer, Peter %A Ramachandran, Vasan S %A Verweij, Niek %A Virtamo, Jarmo %A Völker, Uwe %A Weir, David R %A Zeggini, Eleftheria %A Charchar, Fadi J %A Wareham, Nicholas J %A Langenberg, Claudia %A Tomaszewski, Maciej %A Butterworth, Adam S %A Caulfield, Mark J %A Danesh, John %A Edwards, Todd L %A Holm, Hilma %A Hung, Adriana M %A Lindgren, Cecilia M %A Liu, Chunyu %A Manning, Alisa K %A Morris, Andrew P %A Morrison, Alanna C %A O'Donnell, Christopher J %A Psaty, Bruce M %A Saleheen, Danish %A Stefansson, Kari %A Eric Boerwinkle %A Chasman, Daniel I %A Levy, Daniel %A Newton-Cheh, Christopher %A Munroe, Patricia B %A Howson, Joanna M M %K Blood Pressure %K GATA5 Transcription Factor %K Gene Frequency %K Genetic Predisposition to Disease %K Genome-Wide Association Study %K Genotype %K Humans %K Hypertension %K Mutation %K Phospholipase C beta %K Polymorphism, Single Nucleotide %X

Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were ~8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets.

%B Nat Genet %V 52 %P 1314-1332 %8 2020 Dec %G eng %N 12 %1 https://www.ncbi.nlm.nih.gov/pubmed/33230300?dopt=Abstract %R 10.1038/s41588-020-00713-x %0 Journal Article %J Nat Genet %D 2018 %T Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. %A Evangelou, Evangelos %A Warren, Helen R %A Mosen-Ansorena, David %A Mifsud, Borbala %A Pazoki, Raha %A Gao, He %A Ntritsos, Georgios %A Dimou, Niki %A Cabrera, Claudia P %A Karaman, Ibrahim %A Ng, Fu Liang %A Evangelou, Marina %A Witkowska, Katarzyna %A Tzanis, Evan %A Hellwege, Jacklyn N %A Giri, Ayush %A Velez Edwards, Digna R %A Sun, Yan V %A Cho, Kelly %A Gaziano, J Michael %A Wilson, Peter W F %A Tsao, Philip S %A Kovesdy, Csaba P %A Esko, Tõnu %A Mägi, Reedik %A Milani, Lili %A Almgren, Peter %A Boutin, Thibaud %A Debette, Stephanie %A Ding, Jun %A Giulianini, Franco %A Holliday, Elizabeth G %A Jackson, Anne U %A Li-Gao, Ruifang %A Lin, Wei-Yu %A Luan, Jian'an %A Mangino, Massimo %A Oldmeadow, Christopher %A Prins, Bram Peter %A Qian, Yong %A Sargurupremraj, Muralidharan %A Shah, Nabi %A Surendran, Praveen %A Thériault, Sébastien %A Verweij, Niek %A Willems, Sara M %A Zhao, Jing-Hua %A Amouyel, Philippe %A Connell, John %A de Mutsert, Renée %A Doney, Alex S F %A Farrall, Martin %A Menni, Cristina %A Morris, Andrew D %A Noordam, Raymond %A Paré, Guillaume %A Poulter, Neil R %A Shields, Denis C %A Stanton, Alice %A Thom, Simon %A Abecasis, Goncalo %A Amin, Najaf %A Arking, Dan E %A Ayers, Kristin L %A Barbieri, Caterina M %A Batini, Chiara %A Bis, Joshua C %A Blake, Tineka %A Bochud, Murielle %A Boehnke, Michael %A Eric Boerwinkle %A Boomsma, Dorret I %A Bottinger, Erwin P %A Braund, Peter S %A Brumat, Marco %A Campbell, Archie %A Campbell, Harry %A Chakravarti, Aravinda %A Chambers, John C %A Chauhan, Ganesh %A Ciullo, Marina %A Cocca, Massimiliano %A Collins, Francis %A Cordell, Heather J %A Davies, Gail %A de Borst, Martin H %A de Geus, Eco J %A Deary, Ian J %A Deelen, Joris %A Del Greco M, Fabiola %A Demirkale, Cumhur Yusuf %A Dörr, Marcus %A Ehret, Georg B %A Elosua, Roberto %A Enroth, Stefan %A Erzurumluoglu, A Mesut %A Ferreira, Teresa %A Frånberg, Mattias %A Franco, Oscar H %A Gandin, Ilaria %A Gasparini, Paolo %A Giedraitis, Vilmantas %A Gieger, Christian %A Girotto, Giorgia %A Goel, Anuj %A Gow, Alan J %A Gudnason, Vilmundur %A Guo, Xiuqing %A Gyllensten, Ulf %A Hamsten, Anders %A Harris, Tamara B %A Harris, Sarah E %A Hartman, Catharina A %A Havulinna, Aki S %A Hicks, Andrew A %A Hofer, Edith %A Hofman, Albert %A Hottenga, Jouke-Jan %A Huffman, Jennifer E %A Hwang, Shih-Jen %A Ingelsson, Erik %A James, Alan %A Jansen, Rick %A Jarvelin, Marjo-Riitta %A Joehanes, Roby %A Johansson, Åsa %A Johnson, Andrew D %A Joshi, Peter K %A Jousilahti, Pekka %A Jukema, J Wouter %A Jula, Antti %A Kähönen, Mika %A Kathiresan, Sekar %A Keavney, Bernard D %A Khaw, Kay-Tee %A Knekt, Paul %A Knight, Joanne %A Kolcic, Ivana %A Kooner, Jaspal S %A Koskinen, Seppo %A Kristiansson, Kati %A Kutalik, Zoltán %A Laan, Maris %A Larson, Marty %A Launer, Lenore J %A Lehne, Benjamin %A Lehtimäki, Terho %A Liewald, David C M %A Lin, Li %A Lind, Lars %A Lindgren, Cecilia M %A Liu, Yongmei %A Loos, Ruth J F %A Lopez, Lorna M %A Lu, Yingchang %A Lyytikäinen, Leo-Pekka %A Mahajan, Anubha %A Mamasoula, Chrysovalanto %A Marrugat, Jaume %A Marten, Jonathan %A Milaneschi, Yuri %A Morgan, Anna %A Morris, Andrew P %A Morrison, Alanna C %A Munson, Peter J %A Nalls, Mike A %A Nandakumar, Priyanka %A Nelson, Christopher P %A Niiranen, Teemu %A Nolte, Ilja M %A Nutile, Teresa %A Oldehinkel, Albertine J %A Oostra, Ben A %A O'Reilly, Paul F %A Org, Elin %A Padmanabhan, Sandosh %A Palmas, Walter %A Palotie, Aarno %A Pattie, Alison %A Penninx, Brenda W J H %A Perola, Markus %A Peters, Annette %A Polasek, Ozren %A Pramstaller, Peter P %A Nguyen, Quang Tri %A Raitakari, Olli T %A Ren, Meixia %A Rettig, Rainer %A Rice, Kenneth %A Ridker, Paul M %A Ried, Janina S %A Riese, Harriëtte %A Ripatti, Samuli %A Robino, Antonietta %A Rose, Lynda M %A Rotter, Jerome I %A Rudan, Igor %A Ruggiero, Daniela %A Saba, Yasaman %A Sala, Cinzia F %A Salomaa, Veikko %A Samani, Nilesh J %A Sarin, Antti-Pekka %A Schmidt, Reinhold %A Schmidt, Helena %A Shrine, Nick %A Siscovick, David %A Smith, Albert V %A Snieder, Harold %A Sõber, Siim %A Sorice, Rossella %A Starr, John M %A Stott, David J %A Strachan, David P %A Strawbridge, Rona J %A Sundström, Johan %A Swertz, Morris A %A Taylor, Kent D %A Teumer, Alexander %A Tobin, Martin D %A Tomaszewski, Maciej %A Toniolo, Daniela %A Traglia, Michela %A Trompet, Stella %A Tuomilehto, Jaakko %A Tzourio, Christophe %A Uitterlinden, André G %A Vaez, Ahmad %A van der Most, Peter J %A van Duijn, Cornelia M %A Vergnaud, Anne-Claire %A Verwoert, Germaine C %A Vitart, Veronique %A Völker, Uwe %A Vollenweider, Peter %A Vuckovic, Dragana %A Watkins, Hugh %A Wild, Sarah H %A Willemsen, Gonneke %A Wilson, James F %A Wright, Alan F %A Yao, Jie %A Zemunik, Tatijana %A Zhang, Weihua %A Attia, John R %A Butterworth, Adam S %A Chasman, Daniel I %A Conen, David %A Cucca, Francesco %A Danesh, John %A Hayward, Caroline %A Howson, Joanna M M %A Laakso, Markku %A Lakatta, Edward G %A Langenberg, Claudia %A Melander, Olle %A Mook-Kanamori, Dennis O %A Palmer, Colin N A %A Risch, Lorenz %A Scott, Robert A %A Scott, Rodney J %A Sever, Peter %A Spector, Tim D %A van der Harst, Pim %A Wareham, Nicholas J %A Zeggini, Eleftheria %A Levy, Daniel %A Munroe, Patricia B %A Newton-Cheh, Christopher %A Brown, Morris J %A Metspalu, Andres %A Hung, Adriana M %A O'Donnell, Christopher J %A Edwards, Todd L %A Psaty, Bruce M %A Tzoulaki, Ioanna %A Barnes, Michael R %A Wain, Louise V %A Elliott, Paul %A Caulfield, Mark J %K Adult %K Aged %K Aged, 80 and over %K Blood Pressure %K Cardiovascular Diseases %K Cells, Cultured %K Female %K Genetic Loci %K Genetic Predisposition to Disease %K Genetic Testing %K Genetics, Population %K Genome-Wide Association Study %K Human Umbilical Vein Endothelial Cells %K Humans %K Hypertension %K Life Style %K Male %K Middle Aged %K Polymorphism, Single Nucleotide %K Quantitative Trait Loci %K Risk Factors %X

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

%B Nat Genet %V 50 %P 1412-1425 %8 2018 Oct %G eng %N 10 %1 https://www.ncbi.nlm.nih.gov/pubmed/30224653?dopt=Abstract %R 10.1038/s41588-018-0205-x %0 Journal Article %J Nat Genet %D 2018 %T Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. %A Evangelou, Evangelos %A Warren, Helen R %A Mosen-Ansorena, David %A Mifsud, Borbala %A Pazoki, Raha %A Gao, He %A Ntritsos, Georgios %A Dimou, Niki %A Cabrera, Claudia P %A Karaman, Ibrahim %A Ng, Fu Liang %A Evangelou, Marina %A Witkowska, Katarzyna %A Tzanis, Evan %A Hellwege, Jacklyn N %A Giri, Ayush %A Velez Edwards, Digna R %A Sun, Yan V %A Cho, Kelly %A Gaziano, J Michael %A Wilson, Peter W F %A Tsao, Philip S %A Kovesdy, Csaba P %A Esko, Tõnu %A Mägi, Reedik %A Milani, Lili %A Almgren, Peter %A Boutin, Thibaud %A Debette, Stephanie %A Ding, Jun %A Giulianini, Franco %A Holliday, Elizabeth G %A Jackson, Anne U %A Li-Gao, Ruifang %A Lin, Wei-Yu %A Luan, Jian'an %A Mangino, Massimo %A Oldmeadow, Christopher %A Prins, Bram Peter %A Qian, Yong %A Sargurupremraj, Muralidharan %A Shah, Nabi %A Surendran, Praveen %A Thériault, Sébastien %A Verweij, Niek %A Willems, Sara M %A Zhao, Jing-Hua %A Amouyel, Philippe %A Connell, John %A de Mutsert, Renée %A Doney, Alex S F %A Farrall, Martin %A Menni, Cristina %A Morris, Andrew D %A Noordam, Raymond %A Paré, Guillaume %A Poulter, Neil R %A Shields, Denis C %A Stanton, Alice %A Thom, Simon %A Abecasis, Goncalo %A Amin, Najaf %A Arking, Dan E %A Ayers, Kristin L %A Barbieri, Caterina M %A Batini, Chiara %A Bis, Joshua C %A Blake, Tineka %A Bochud, Murielle %A Boehnke, Michael %A Eric Boerwinkle %A Boomsma, Dorret I %A Bottinger, Erwin P %A Braund, Peter S %A Brumat, Marco %A Campbell, Archie %A Campbell, Harry %A Chakravarti, Aravinda %A Chambers, John C %A Chauhan, Ganesh %A Ciullo, Marina %A Cocca, Massimiliano %A Collins, Francis %A Cordell, Heather J %A Davies, Gail %A de Borst, Martin H %A de Geus, Eco J %A Deary, Ian J %A Deelen, Joris %A Del Greco M, Fabiola %A Demirkale, Cumhur Yusuf %A Dörr, Marcus %A Ehret, Georg B %A Elosua, Roberto %A Enroth, Stefan %A Erzurumluoglu, A Mesut %A Ferreira, Teresa %A Frånberg, Mattias %A Franco, Oscar H %A Gandin, Ilaria %A Gasparini, Paolo %A Giedraitis, Vilmantas %A Gieger, Christian %A Girotto, Giorgia %A Goel, Anuj %A Gow, Alan J %A Gudnason, Vilmundur %A Guo, Xiuqing %A Gyllensten, Ulf %A Hamsten, Anders %A Harris, Tamara B %A Harris, Sarah E %A Hartman, Catharina A %A Havulinna, Aki S %A Hicks, Andrew A %A Hofer, Edith %A Hofman, Albert %A Hottenga, Jouke-Jan %A Huffman, Jennifer E %A Hwang, Shih-Jen %A Ingelsson, Erik %A James, Alan %A Jansen, Rick %A Jarvelin, Marjo-Riitta %A Joehanes, Roby %A Johansson, Åsa %A Johnson, Andrew D %A Joshi, Peter K %A Jousilahti, Pekka %A Jukema, J Wouter %A Jula, Antti %A Kähönen, Mika %A Kathiresan, Sekar %A Keavney, Bernard D %A Khaw, Kay-Tee %A Knekt, Paul %A Knight, Joanne %A Kolcic, Ivana %A Kooner, Jaspal S %A Koskinen, Seppo %A Kristiansson, Kati %A Kutalik, Zoltán %A Laan, Maris %A Larson, Marty %A Launer, Lenore J %A Lehne, Benjamin %A Lehtimäki, Terho %A Liewald, David C M %A Lin, Li %A Lind, Lars %A Lindgren, Cecilia M %A Liu, Yongmei %A Loos, Ruth J F %A Lopez, Lorna M %A Lu, Yingchang %A Lyytikäinen, Leo-Pekka %A Mahajan, Anubha %A Mamasoula, Chrysovalanto %A Marrugat, Jaume %A Marten, Jonathan %A Milaneschi, Yuri %A Morgan, Anna %A Morris, Andrew P %A Morrison, Alanna C %A Munson, Peter J %A Nalls, Mike A %A Nandakumar, Priyanka %A Nelson, Christopher P %A Niiranen, Teemu %A Nolte, Ilja M %A Nutile, Teresa %A Oldehinkel, Albertine J %A Oostra, Ben A %A O'Reilly, Paul F %A Org, Elin %A Padmanabhan, Sandosh %A Palmas, Walter %A Palotie, Aarno %A Pattie, Alison %A Penninx, Brenda W J H %A Perola, Markus %A Peters, Annette %A Polasek, Ozren %A Pramstaller, Peter P %A Nguyen, Quang Tri %A Raitakari, Olli T %A Ren, Meixia %A Rettig, Rainer %A Rice, Kenneth %A Ridker, Paul M %A Ried, Janina S %A Riese, Harriëtte %A Ripatti, Samuli %A Robino, Antonietta %A Rose, Lynda M %A Rotter, Jerome I %A Rudan, Igor %A Ruggiero, Daniela %A Saba, Yasaman %A Sala, Cinzia F %A Salomaa, Veikko %A Samani, Nilesh J %A Sarin, Antti-Pekka %A Schmidt, Reinhold %A Schmidt, Helena %A Shrine, Nick %A Siscovick, David %A Smith, Albert V %A Snieder, Harold %A Sõber, Siim %A Sorice, Rossella %A Starr, John M %A Stott, David J %A Strachan, David P %A Strawbridge, Rona J %A Sundström, Johan %A Swertz, Morris A %A Taylor, Kent D %A Teumer, Alexander %A Tobin, Martin D %A Tomaszewski, Maciej %A Toniolo, Daniela %A Traglia, Michela %A Trompet, Stella %A Tuomilehto, Jaakko %A Tzourio, Christophe %A Uitterlinden, André G %A Vaez, Ahmad %A van der Most, Peter J %A van Duijn, Cornelia M %A Vergnaud, Anne-Claire %A Verwoert, Germaine C %A Vitart, Veronique %A Völker, Uwe %A Vollenweider, Peter %A Vuckovic, Dragana %A Watkins, Hugh %A Wild, Sarah H %A Willemsen, Gonneke %A Wilson, James F %A Wright, Alan F %A Yao, Jie %A Zemunik, Tatijana %A Zhang, Weihua %A Attia, John R %A Butterworth, Adam S %A Chasman, Daniel I %A Conen, David %A Cucca, Francesco %A Danesh, John %A Hayward, Caroline %A Howson, Joanna M M %A Laakso, Markku %A Lakatta, Edward G %A Langenberg, Claudia %A Melander, Olle %A Mook-Kanamori, Dennis O %A Palmer, Colin N A %A Risch, Lorenz %A Scott, Robert A %A Scott, Rodney J %A Sever, Peter %A Spector, Tim D %A van der Harst, Pim %A Wareham, Nicholas J %A Zeggini, Eleftheria %A Levy, Daniel %A Munroe, Patricia B %A Newton-Cheh, Christopher %A Brown, Morris J %A Metspalu, Andres %A Hung, Adriana M %A O'Donnell, Christopher J %A Edwards, Todd L %A Psaty, Bruce M %A Tzoulaki, Ioanna %A Barnes, Michael R %A Wain, Louise V %A Elliott, Paul %A Caulfield, Mark J %X

In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML. The error has now been corrected in the HTML version of the paper.

%B Nat Genet %V 50 %P 1755 %8 2018 Dec %G eng %N 12 %1 https://www.ncbi.nlm.nih.gov/pubmed/30429575?dopt=Abstract %R 10.1038/s41588-018-0297-3