%0 Journal Article %J Epigenomics %D 2020 %T Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems. %A Justice, Anne E %A Chittoor, Geetha %A Gondalia, Rahul %A Melton, Phillip E %A Lim, Elise %A Grove, Megan L %A Whitsel, Eric A %A Liu, Ching-Ti %A Cupples, L Adrienne %A Fernandez-Rhodes, Lindsay %A Guan, Weihua %A Bressler, Jan %A Fornage, Myriam %A Eric Boerwinkle %A Li, Yun %A Demerath, Ellen %A Heard-Costa, Nancy %A Levy, Dan %A Stewart, James D %A Baccarelli, Andrea %A Hou, Lifang %A Conneely, Karen %A Mori, Trevor A %A Beilin, Lawrence J %A Huang, Rae-Chi %A Gordon-Larsen, Penny %A Howard, Annie Green %A North, Kari E %K Adiposity %K Cohort Studies %K CpG Islands %K Disease Susceptibility %K DNA Methylation %K Endocrine System %K Epigenesis, Genetic %K Epigenomics %K Genome-Wide Association Study %K Humans %K Immune System %K Obesity %X

We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820). We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near , ,  and that had not previously been associated with obesity-related traits.

%B Epigenomics %V 12 %P 1483-1499 %8 2020 Sep %G eng %N 17 %1 https://www.ncbi.nlm.nih.gov/pubmed/32901515?dopt=Abstract %R 10.2217/epi-2019-0276