%0 Journal Article %J J Pediatr Hematol Oncol %D 2017 %T Therapy-related Acute Leukemia With Mixed Phenotype and Novel t(1: 6)(q25;p23) After Treatment for High-risk Neuroblastoma. %A Whittle, Sarah B %A Punia, Jyotinder N %A López-Terrada, Dolores %A Gaikwad, Amos %A Hampton, Oliver A %A Heczey, Andras %K Antineoplastic Combined Chemotherapy Protocols %K Biopsy %K Bone Marrow %K Child, Preschool %K Chromosome Banding %K Chromosomes, Human, Pair 1 %K Chromosomes, Human, Pair 6 %K Fatal Outcome %K Female %K Hematopoietic Stem Cell Transplantation %K Humans %K Immunophenotyping %K Leukemia, Myeloid, Acute %K Myelodysplastic Syndromes %K Neoplasms, Second Primary %K Neuroblastoma %K Phenotype %K Translocation, Genetic %K Transplantation Conditioning %X

Neuroblastoma is the most common extracranial malignancy of childhood. Patients with high-risk disease receive multimodal treatment including chemotherapy combinations containing alkylating agents and topoisomerase inhibitors with potential for inducing therapy-related malignancy later in life. Most commonly, cytogenetic changes of pediatric therapy-related myelodysplastic syndrome/acute myeloid leukemia involve chromosome 5 or 7. Here we report a novel case of therapy-related myelodysplastic syndrome/acute myeloid leukemia 30 months after treatment for high-risk neuroblastoma with biphenotypic cell surface markers and a not yet described translocation t(1;6)(q25;p23).

%B J Pediatr Hematol Oncol %V 39 %P e486-e488 %8 2017 11 %G eng %N 8 %1 https://www.ncbi.nlm.nih.gov/pubmed/28902076?dopt=Abstract %R 10.1097/MPH.0000000000000956