%0 Journal Article %J PLoS Negl Trop Dis %D 2023 %T Genomic analysis of two phlebotomine sand fly vectors of Leishmania from the New and Old World. %A Labbé, Frédéric %A Abdeladhim, Maha %A Abrudan, Jenica %A Araki, Alejandra Saori %A Araujo, Ricardo N %A Arensburger, Peter %A Benoit, Joshua B %A Brazil, Reginaldo Pecanha %A Bruno, Rafaela V %A Bueno da Silva Rivas, Gustavo %A Carvalho de Abreu, Vinicius %A Charamis, Jason %A Coutinho-Abreu, Iliano V %A da Costa-Latgé, Samara G %A Darby, Alistair %A Dillon, Viv M %A Emrich, Scott J %A Fernandez-Medina, Daniela %A Figueiredo Gontijo, Nelder %A Flanley, Catherine M %A Gatherer, Derek %A Genta, Fernando A %A Gesing, Sandra %A Giraldo-Calderón, Gloria I %A Gomes, Bruno %A Aguiar, Eric Roberto Guimaraes Rocha %A Hamilton, James G C %A Hamarsheh, Omar %A Hawksworth, Mallory %A Hendershot, Jacob M %A Hickner, Paul V %A Imler, Jean-Luc %A Ioannidis, Panagiotis %A Jennings, Emily C %A Kamhawi, Shaden %A Karageorgiou, Charikleia %A Kennedy, Ryan C %A Krueger, Andreas %A Latorre-Estivalis, José M %A Ligoxygakis, Petros %A Meireles-Filho, Antonio Carlos A %A Minx, Patrick %A Miranda, Jose Carlos %A Montague, Michael J %A Nowling, Ronald J %A Oliveira, Fabiano %A Ortigão-Farias, João %A Pavan, Marcio G %A Horacio Pereira, Marcos %A Nobrega Pitaluga, Andre %A Proveti Olmo, Roenick %A Ramalho-Ortigao, Marcelo %A Ribeiro, Jose M C %A Rosendale, Andrew J %A Sant'Anna, Mauricio R V %A Steven E Scherer %A Secundino, Nágila F C %A Shoue, Douglas A %A da Silva Moraes, Caroline %A Gesto, João Silveira Moledo %A Souza, Nataly Araujo %A Syed, Zainulabueddin %A Tadros, Samuel %A Teles-de-Freitas, Rayane %A Telleria, Erich L %A Tomlinson, Chad %A Traub-Csekö, Yara M %A Marques, João Trindade %A Tu, Zhijian %A Unger, Maria F %A Valenzuela, Jesus %A Ferreira, Flávia V %A de Oliveira, Karla P V %A Vigoder, Felipe M %A Vontas, John %A Wang, Lihui %A Weedall, Gareth D %A Zhioua, Elyes %A Stephen Richards %A Warren, Wesley C %A Waterhouse, Robert M %A Dillon, Rod J %A McDowell, Mary Ann %K Animals %K Genomics %K Humans %K Leishmania %K Leishmaniasis, Cutaneous %K Phlebotomus %K Psychodidae %X

Phlebotomine sand flies are of global significance as important vectors of human disease, transmitting bacterial, viral, and protozoan pathogens, including the kinetoplastid parasites of the genus Leishmania, the causative agents of devastating diseases collectively termed leishmaniasis. More than 40 pathogenic Leishmania species are transmitted to humans by approximately 35 sand fly species in 98 countries with hundreds of millions of people at risk around the world. No approved efficacious vaccine exists for leishmaniasis and available therapeutic drugs are either toxic and/or expensive, or the parasites are becoming resistant to the more recently developed drugs. Therefore, sand fly and/or reservoir control are currently the most effective strategies to break transmission. To better understand the biology of sand flies, including the mechanisms involved in their vectorial capacity, insecticide resistance, and population structures we sequenced the genomes of two geographically widespread and important sand fly vector species: Phlebotomus papatasi, a vector of Leishmania parasites that cause cutaneous leishmaniasis, (distributed in Europe, the Middle East and North Africa) and Lutzomyia longipalpis, a vector of Leishmania parasites that cause visceral leishmaniasis (distributed across Central and South America). We categorized and curated genes involved in processes important to their roles as disease vectors, including chemosensation, blood feeding, circadian rhythm, immunity, and detoxification, as well as mobile genetic elements. We also defined gene orthology and observed micro-synteny among the genomes. Finally, we present the genetic diversity and population structure of these species in their respective geographical areas. These genomes will be a foundation on which to base future efforts to prevent vector-borne transmission of Leishmania parasites.

%B PLoS Negl Trop Dis %V 17 %P e0010862 %8 2023 Apr %G eng %N 4 %1 https://www.ncbi.nlm.nih.gov/pubmed/37043542?dopt=Abstract %R 10.1371/journal.pntd.0010862 %0 Journal Article %J Nature %D 2008 %T The genome of the model beetle and pest Tribolium castaneum. %A Stephen Richards %A Richard A Gibbs %A Weinstock, George M %A Brown, Susan J %A Denell, Robin %A Beeman, Richard W %A Richard A Gibbs %A Beeman, Richard W %A Brown, Susan J %A Bucher, Gregor %A Friedrich, Markus %A Grimmelikhuijzen, Cornelis J P %A Klingler, Martin %A Lorenzen, Marce %A Stephen Richards %A Roth, Siegfried %A Schröder, Reinhard %A Tautz, Diethard %A Zdobnov, Evgeny M %A Donna M Muzny %A Richard A Gibbs %A Weinstock, George M %A Attaway, Tony %A Bell, Stephanie %A Buhay, Christian J %A Chandrabose, Mimi N %A Chavez, Dean %A Clerk-Blankenburg, Kerstin P %A Cree, Andrew %A Dao, Marvin %A Davis, Clay %A Chacko, Joseph %A Dinh, Huyen %A Dugan-Rocha, Shannon %A Fowler, Gerald %A Garner, Toni T %A Garnes, Jeffrey %A Gnirke, Andreas %A Hawes, Alica %A Hernandez, Judith %A Hines, Sandra %A Holder, Michael %A Hume, Jennifer %A Jhangiani, Shalini N %A Joshi, Vandita %A Ziad Khan %A Jackson, Laronda %A Kovar, Christie %A Kowis, Andrea %A Lee, Sandra %A Lewis, Lora R %A Margolis, Jon %A Morgan, Margaret %A Nazareth, Lynne V %A Nguyen, Ngoc %A Okwuonu, Geoffrey %A Parker, David %A Stephen Richards %A Ruiz, San-Juana %A Santibanez, Jireh %A Savard, Joël %A Steven E Scherer %A Schneider, Brian %A Sodergren, Erica %A Tautz, Diethard %A Vattahil, Selina %A Villasana, Donna %A White, Courtney S %A Wright, Rita %A Park, Yoonseong %A Beeman, Richard W %A Lord, Jeff %A Oppert, Brenda %A Lorenzen, Marce %A Brown, Susan %A Wang, Liangjiang %A Savard, Joël %A Tautz, Diethard %A Stephen Richards %A Weinstock, George %A Richard A Gibbs %A Liu, Yue %A Kim C Worley %A Weinstock, George %A Elsik, Christine G %A Reese, Justin T %A Elhaik, Eran %A Landan, Giddy %A Graur, Dan %A Arensburger, Peter %A Atkinson, Peter %A Beeman, Richard W %A Beidler, Jim %A Brown, Susan J %A Demuth, Jeffery P %A Drury, Douglas W %A Du, Yu-Zhou %A Fujiwara, Haruhiko %A Lorenzen, Marce %A Maselli, Vincenza %A Osanai, Mizuko %A Park, Yoonseong %A Robertson, Hugh M %A Tu, Zhijian %A Wang, Jian-jun %A Wang, Suzhi %A Stephen Richards %A Song, Henry %A Zhang, Lan %A Sodergren, Erica %A Werner, Doreen %A Stanke, Mario %A Morgenstern, Burkhard %A Solovyev, Victor %A Kosarev, Peter %A Brown, Garth %A Chen, Hsiu-Chuan %A Ermolaeva, Olga %A Hlavina, Wratko %A Kapustin, Yuri %A Kiryutin, Boris %A Kitts, Paul %A Maglott, Donna %A Pruitt, Kim %A Sapojnikov, Victor %A Souvorov, Alexandre %A Mackey, Aaron J %A Waterhouse, Robert M %A Wyder, Stefan %A Zdobnov, Evgeny M %A Zdobnov, Evgeny M %A Wyder, Stefan %A Kriventseva, Evgenia V %A Kadowaki, Tatsuhiko %A Bork, Peer %A Aranda, Manuel %A Bao, Riyue %A Beermann, Anke %A Berns, Nicola %A Bolognesi, Renata %A Bonneton, François %A Bopp, Daniel %A Brown, Susan J %A Bucher, Gregor %A Butts, Thomas %A Chaumot, Arnaud %A Denell, Robin E %A Ferrier, David E K %A Friedrich, Markus %A Gordon, Cassondra M %A Jindra, Marek %A Klingler, Martin %A Lan, Que %A Lattorff, H Michael G %A Laudet, Vincent %A von Levetsow, Cornelia %A Liu, Zhenyi %A Lutz, Rebekka %A Lynch, Jeremy A %A da Fonseca, Rodrigo Nunes %A Posnien, Nico %A Reuter, Rolf %A Roth, Siegfried %A Savard, Joël %A Schinko, Johannes B %A Schmitt, Christian %A Schoppmeier, Michael %A Schröder, Reinhard %A Shippy, Teresa D %A Simonnet, Franck %A Marques-Souza, Henrique %A Tautz, Diethard %A Tomoyasu, Yoshinori %A Trauner, Jochen %A Van der Zee, Maurijn %A Vervoort, Michel %A Wittkopp, Nadine %A Wimmer, Ernst A %A Yang, Xiaoyun %A Jones, Andrew K %A Sattelle, David B %A Ebert, Paul R %A Nelson, David %A Scott, Jeffrey G %A Beeman, Richard W %A Muthukrishnan, Subbaratnam %A Kramer, Karl J %A Arakane, Yasuyuki %A Beeman, Richard W %A Zhu, Qingsong %A Hogenkamp, David %A Dixit, Radhika %A Oppert, Brenda %A Jiang, Haobo %A Zou, Zhen %A Marshall, Jeremy %A Elpidina, Elena %A Vinokurov, Konstantin %A Oppert, Cris %A Zou, Zhen %A Evans, Jay %A Lu, Zhiqiang %A Zhao, Picheng %A Sumathipala, Niranji %A Altincicek, Boran %A Vilcinskas, Andreas %A Williams, Michael %A Hultmark, Dan %A Hetru, Charles %A Jiang, Haobo %A Grimmelikhuijzen, Cornelis J P %A Hauser, Frank %A Cazzamali, Giuseppe %A Williamson, Michael %A Park, Yoonseong %A Li, Bin %A Tanaka, Yoshiaki %A Predel, Reinhard %A Neupert, Susanne %A Schachtner, Joachim %A Verleyen, Peter %A Raible, Florian %A Bork, Peer %A Friedrich, Markus %A Walden, Kimberly K O %A Robertson, Hugh M %A Angeli, Sergio %A Forêt, Sylvain %A Bucher, Gregor %A Schuetz, Stefan %A Maleszka, Ryszard %A Wimmer, Ernst A %A Beeman, Richard W %A Lorenzen, Marce %A Tomoyasu, Yoshinori %A Miller, Sherry C %A Grossmann, Daniela %A Bucher, Gregor %K Animals %K Base Composition %K Body Patterning %K Cytochrome P-450 Enzyme System %K DNA Transposable Elements %K Genes, Insect %K Genome, Insect %K Growth and Development %K Humans %K Insecticides %K Neurotransmitter Agents %K Oogenesis %K Phylogeny %K Proteome %K Receptors, G-Protein-Coupled %K Receptors, Odorant %K Repetitive Sequences, Nucleic Acid %K RNA Interference %K Taste %K Telomere %K Tribolium %K Vision, Ocular %X

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.

%B Nature %V 452 %P 949-55 %8 2008 Apr 24 %G eng %N 7190 %1 https://www.ncbi.nlm.nih.gov/pubmed/18362917?dopt=Abstract %R 10.1038/nature06784