%0 Journal Article %J Lancet %D 1990 %T Long HIV-1 incubation periods and dynamics of transmission within a family. %A Burger, H %A Belman, A L %A Grimson, R %A Kaell, A %A Flaherty, K %A Gulla, J %A Richard A Gibbs %A Nguyun, P N %A Weiser, B %K Acquired Immunodeficiency Syndrome %K Adolescent %K Adult %K CD4-Positive T-Lymphocytes %K Child %K DNA, Viral %K Family %K Family Health %K Female %K HIV Antibodies %K HIV Seropositivity %K HIV-1 %K Humans %K Leukocyte Count %K Male %K Sexual Behavior %K Substance Abuse, Intravenous %K Time Factors %X

The incubation period of human immunodeficiency virus type 1 (HIV-1) infection was studied in a family of five in which vertical and heterosexual transmission occurred from one index case. This investigation documented incubation periods of longer than 12 years in a mother and her daughter; although neither has symptoms, both are definitely infected and have very low CD4(+)-lymphocyte counts. The study confirmed the predictions of incubation periods longer than 10 years in a small proportion of infected individuals. It provides evidence that vertically HIV-1-infected teenagers can be expected to appear in the population.

%B Lancet %V 336 %P 134-6 %8 1990 Jul 21 %G eng %N 8708 %1 https://www.ncbi.nlm.nih.gov/pubmed/1973471?dopt=Abstract %R 10.1016/0140-6736(90)91657-v