%0 Journal Article %J BMC Genomics %D 2020 %T Brown marmorated stink bug, Halyomorpha halys (Stål), genome: putative underpinnings of polyphagy, insecticide resistance potential and biology of a top worldwide pest. %A Sparks, Michael E %A Bansal, Raman %A Benoit, Joshua B %A Blackburn, Michael B %A Chao, Hsu %A Chen, Mengyao %A Cheng, Sammy %A Childers, Christopher %A Dinh, Huyen %A Harshavardhan Doddapaneni %A Dugan, Shannon %A Elpidina, Elena N %A Farrow, David W %A Friedrich, Markus %A Richard A Gibbs %A Hall, Brantley %A Yi Han %A Hardy, Richard W %A Holmes, Christopher J %A Hughes, Daniel S T %A Ioannidis, Panagiotis %A Cheatle Jarvela, Alys M %A Johnston, J Spencer %A Jones, Jeffery W %A Kronmiller, Brent A %A Kung, Faith %A Lee, Sandra L %A Martynov, Alexander G %A Masterson, Patrick %A Maumus, Florian %A Munoz-Torres, Monica %A Murali, Shwetha C %A Murphy, Terence D %A Donna M Muzny %A Nelson, David R %A Oppert, Brenda %A Panfilio, Kristen A %A Paula, Débora Pires %A Pick, Leslie %A Poelchau, Monica F %A Qu, Jiaxin %A Reding, Katie %A Rhoades, Joshua H %A Rhodes, Adelaide %A Stephen Richards %A Richter, Rose %A Robertson, Hugh M %A Rosendale, Andrew J %A Tu, Zhijian Jake %A Velamuri, Arun S %A Waterhouse, Robert M %A Weirauch, Matthew T %A Wells, Jackson T %A Werren, John H %A Kim C Worley %A Zdobnov, Evgeny M %A Gundersen-Rindal, Dawn E %K Animals %K Ecosystem %K Gene Transfer, Horizontal %K Genome Size %K Heteroptera %K Insect Proteins %K Insecticide Resistance %K Introduced Species %K Phylogeny %K Whole Genome Sequencing %X

BACKGROUND: Halyomorpha halys (Stål), the brown marmorated stink bug, is a highly invasive insect species due in part to its exceptionally high levels of polyphagy. This species is also a nuisance due to overwintering in human-made structures. It has caused significant agricultural losses in recent years along the Atlantic seaboard of North America and in continental Europe. Genomic resources will assist with determining the molecular basis for this species' feeding and habitat traits, defining potential targets for pest management strategies.

RESULTS: Analysis of the 1.15-Gb draft genome assembly has identified a wide variety of genetic elements underpinning the biological characteristics of this formidable pest species, encompassing the roles of sensory functions, digestion, immunity, detoxification and development, all of which likely support H. halys' capacity for invasiveness. Many of the genes identified herein have potential for biomolecular pesticide applications.

CONCLUSIONS: Availability of the H. halys genome sequence will be useful for the development of environmentally friendly biomolecular pesticides to be applied in concert with more traditional, synthetic chemical-based controls.

%B BMC Genomics %V 21 %P 227 %8 2020 Mar 14 %G eng %N 1 %1 https://www.ncbi.nlm.nih.gov/pubmed/32171258?dopt=Abstract %R 10.1186/s12864-020-6510-7 %0 Journal Article %J Nat Commun %D 2016 %T Unique features of a global human ectoparasite identified through sequencing of the bed bug genome. %A Benoit, Joshua B %A Adelman, Zach N %A Reinhardt, Klaus %A Dolan, Amanda %A Poelchau, Monica %A Jennings, Emily C %A Szuter, Elise M %A Hagan, Richard W %A Gujar, Hemant %A Shukla, Jayendra Nath %A Zhu, Fang %A Mohan, M %A Nelson, David R %A Rosendale, Andrew J %A Derst, Christian %A Resnik, Valentina %A Wernig, Sebastian %A Menegazzi, Pamela %A Wegener, Christian %A Peschel, Nicolai %A Hendershot, Jacob M %A Blenau, Wolfgang %A Predel, Reinhard %A Johnston, Paul R %A Ioannidis, Panagiotis %A Waterhouse, Robert M %A Nauen, Ralf %A Schorn, Corinna %A Ott, Mark-Christoph %A Maiwald, Frank %A Johnston, J Spencer %A Gondhalekar, Ameya D %A Scharf, Michael E %A Peterson, Brittany F %A Raje, Kapil R %A Hottel, Benjamin A %A Armisén, David %A Crumière, Antonin Jean Johan %A Refki, Peter Nagui %A Santos, Maria Emilia %A Sghaier, Essia %A Viala, Sèverine %A Khila, Abderrahman %A Ahn, Seung-Joon %A Childers, Christopher %A Lee, Chien-Yueh %A Lin, Han %A Hughes, Daniel S T %A Duncan, Elizabeth J %A Murali, Shwetha C %A Qu, Jiaxin %A Dugan, Shannon %A Lee, Sandra L %A Chao, Hsu %A Dinh, Huyen %A Han, Yi %A Doddapaneni, Harshavardhan %A Worley, Kim C %A Muzny, Donna M %A Wheeler, David %A Panfilio, Kristen A %A Vargas Jentzsch, Iris M %A Vargo, Edward L %A Booth, Warren %A Friedrich, Markus %A Weirauch, Matthew T %A Anderson, Michelle A E %A Jones, Jeffery W %A Mittapalli, Omprakash %A Zhao, Chaoyang %A Zhou, Jing-Jiang %A Evans, Jay D %A Attardo, Geoffrey M %A Robertson, Hugh M %A Zdobnov, Evgeny M %A Ribeiro, Jose M C %A Gibbs, Richard A %A Werren, John H %A Palli, Subba R %A Schal, Coby %A Richards, Stephen %K Animals %K Bedbugs %K Ectoparasitic Infestations %K Feeding Behavior %K Gene Transfer, Horizontal %K Genome %K Host-Parasite Interactions %K Humans %K Insecticide Resistance %K Insecticides %K Sequence Analysis, DNA %X

The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host-symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human-bed bug and symbiont-bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite.

%B Nat Commun %V 7 %P 10165 %8 2016 Feb 02 %G eng %1 https://www.ncbi.nlm.nih.gov/pubmed/26836814?dopt=Abstract %R 10.1038/ncomms10165 %0 Journal Article %J Nat Commun %D 2015 %T Lucilia cuprina genome unlocks parasitic fly biology to underpin future interventions. %A Anstead, Clare A %A Korhonen, Pasi K %A Young, Neil D %A Hall, Ross S %A Jex, Aaron R %A Murali, Shwetha C %A Hughes, Daniel S T %A Lee, Siu F %A Perry, Trent %A Stroehlein, Andreas J %A Ansell, Brendan R E %A Breugelmans, Bert %A Hofmann, Andreas %A Qu, Jiaxin %A Dugan, Shannon %A Lee, Sandra L %A Chao, Hsu %A Dinh, Huyen %A Han, Yi %A Doddapaneni, Harsha V %A Worley, Kim C %A Muzny, Donna M %A Ioannidis, Panagiotis %A Waterhouse, Robert M %A Zdobnov, Evgeny M %A James, Peter J %A Bagnall, Neil H %A Kotze, Andrew C %A Gibbs, Richard A %A Richards, Stephen %A Batterham, Philip %A Gasser, Robin B %K Animals %K Diptera %K Female %K Gene Expression Regulation %K Genome, Insect %K Insect Proteins %K Insecticide Resistance %K Insecticides %K Larva %K Male %K Transcriptome %X

Lucilia cuprina is a parasitic fly of major economic importance worldwide. Larvae of this fly invade their animal host, feed on tissues and excretions and progressively cause severe skin disease (myiasis). Here we report the sequence and annotation of the 458-megabase draft genome of Lucilia cuprina. Analyses of this genome and the 14,544 predicted protein-encoding genes provide unique insights into the fly's molecular biology, interactions with the host animal and insecticide resistance. These insights have broad implications for designing new methods for the prevention and control of myiasis.

%B Nat Commun %V 6 %P 7344 %8 2015 Jun 25 %G eng %1 https://www.ncbi.nlm.nih.gov/pubmed/26108605?dopt=Abstract %R 10.1038/ncomms8344