Expression of the murine Duchenne muscular dystrophy gene in muscle and brain.

TitleExpression of the murine Duchenne muscular dystrophy gene in muscle and brain.
Publication TypeJournal Article
Year of Publication1988
AuthorsChamberlain, JS, Pearlman, JA, Muzny, DM, Gibbs, RA, Ranier, JE, Caskey, CT, Reeves, AA
JournalScience
Volume239
Issue4846
Pagination1416-8
Date Published1988 Mar 18
ISSN0036-8075
KeywordsAnimals, Brain, DNA, DNA, Recombinant, Gene Expression Regulation, Intellectual Disability, Mice, Mice, Inbred ICR, Mice, Mutant Strains, Muscles, Muscular Dystrophy, Animal, Mutation, Nucleic Acid Hybridization, Ribonuclease, Pancreatic, RNA, Messenger
Abstract

Complementary DNA clones were isolated that represent the 5' terminal 2.5 kilobases of the murine Duchenne muscular dystrophy (Dmd) messenger RNA (mRNA). Mouse Dmd mRNA was detectable in skeletal and cardiac muscle and at a level approximately 90 percent lower in brain. Dmd mRNA is also present, but at much lower than normal levels, in both the muscle and brain of three different strains of dystrophic mdx mice. The identification of Dmd mRNA in brain raises the possibility of a relation between human Duchenne muscular dystrophy (DMD) gene expression and the mental retardation found in some DMD males. These results also provide evidence that the mdx mutations are allelic variants of mouse Dmd gene mutations.

Alternate JournalScience
PubMed ID3347839