FAIR Header Reference genome: a TRUSTworthy standard.

TitleFAIR Header Reference genome: a TRUSTworthy standard.
Publication TypeJournal Article
Year of Publication2024
AuthorsWright, A, Wilkinson, MD, Mungall, C, Cain, S, Richards, S, Sternberg, P, Provin, E, Jacobs, JL, Geib, S, Raciti, D, Yook, K, Stein, L, Molik, DC
JournalBrief Bioinform
Date Published2024 Mar 27
KeywordsEcosystem, Genome, Genomics, Humans, Information Dissemination, Software

The lack of interoperable data standards among reference genome data-sharing platforms inhibits cross-platform analysis while increasing the risk of data provenance loss. Here, we describe the FAIR bioHeaders Reference genome (FHR), a metadata standard guided by the principles of Findability, Accessibility, Interoperability and Reuse (FAIR) in addition to the principles of Transparency, Responsibility, User focus, Sustainability and Technology. The objective of FHR is to provide an extensive set of data serialisation methods and minimum data field requirements while still maintaining extensibility, flexibility and expressivity in an increasingly decentralised genomic data ecosystem. The effort needed to implement FHR is low; FHR's design philosophy ensures easy implementation while retaining the benefits gained from recording both machine and human-readable provenance.

Alternate JournalBrief Bioinform
PubMed ID38555475
PubMed Central IDPMC10981671
Grant ListU24 HG002223 / HG / NHGRI NIH HHS / United States

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